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- W4306784171 abstract "The primary subtypes of renal cell carcinoma (RCC) include clear cell, papillary and chromophobe RCC. RCC occurs often due to loss of von Hippel‑Lindau (VHL) and accumulation of lipids and glycogen, and RCC cells may exhibit sensitivity to the disruption of normal metabolism or homologous recombination gene defect. Although the application of molecular‑targeted drugs (tyrosine kinase inhibitors) and immune checkpoint inhibitors has been recommended for the treatment of advanced RCC, more targets of DNA damage repair (DDR) signaling pathway involved in the synthetic lethal effect have been investigated. However, although achievements has been made in the exploration of the roles of DDR genes on RCC progression, their association has not been systematically summarized. Poly (ADP‑ribose) polymerase (PARP) 1 inhibitors are used in tumors with BRCA1/2 DNA repair‑associated mutations. PARP family enzymes perform post‑translational modification functions and participate in DDR and cell death. Inhibitors of PARP, ataxia telangiectasia mutant gene and polymerase θ serve key roles in the treatment of specific RCC subtypes. PARP1 may serve as an important biological marker to predict the therapeutic effect of immune checkpoint inhibitors and evaluate the prognosis of patients with ccRCC with polybromo 1 mutation. Therefore, the roles of DDR pathway on RCC progression or treatment may hold promises for the treatment of certain specific types of RCC." @default.
- W4306784171 created "2022-10-19" @default.
- W4306784171 creator A5001805708 @default.
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- W4306784171 date "2022-10-19" @default.
- W4306784171 modified "2023-09-29" @default.
- W4306784171 title "Roles of DNA damage repair and precise targeted therapy in renal cancer (Review)" @default.
- W4306784171 cites W1959879209 @default.
- W4306784171 cites W1971954823 @default.
- W4306784171 cites W1979350314 @default.
- W4306784171 cites W1986804628 @default.
- W4306784171 cites W2009899606 @default.
- W4306784171 cites W2022195980 @default.
- W4306784171 cites W2048305487 @default.
- W4306784171 cites W2049028195 @default.
- W4306784171 cites W2052025850 @default.
- W4306784171 cites W2062422180 @default.
- W4306784171 cites W2064072638 @default.
- W4306784171 cites W2066488891 @default.
- W4306784171 cites W2070665930 @default.
- W4306784171 cites W2086665516 @default.
- W4306784171 cites W2098737737 @default.
- W4306784171 cites W2106910596 @default.
- W4306784171 cites W2115928549 @default.
- W4306784171 cites W2120574701 @default.
- W4306784171 cites W2186240607 @default.
- W4306784171 cites W2294083772 @default.
- W4306784171 cites W2514291160 @default.
- W4306784171 cites W2519857264 @default.
- W4306784171 cites W2529744299 @default.
- W4306784171 cites W2534471526 @default.
- W4306784171 cites W2553815939 @default.
- W4306784171 cites W2560456401 @default.
- W4306784171 cites W2587333476 @default.
- W4306784171 cites W2588135595 @default.
- W4306784171 cites W2597062310 @default.
- W4306784171 cites W2602446259 @default.
- W4306784171 cites W2604077136 @default.
- W4306784171 cites W2606089517 @default.
- W4306784171 cites W2607225256 @default.
- W4306784171 cites W2610599595 @default.
- W4306784171 cites W2732346161 @default.
- W4306784171 cites W2736705022 @default.
- W4306784171 cites W2741729555 @default.
- W4306784171 cites W2744461100 @default.
- W4306784171 cites W2778494542 @default.
- W4306784171 cites W2782183686 @default.
- W4306784171 cites W2784814401 @default.
- W4306784171 cites W2796568613 @default.
- W4306784171 cites W2811053845 @default.
- W4306784171 cites W2884857090 @default.
- W4306784171 cites W2888708599 @default.
- W4306784171 cites W2890126224 @default.
- W4306784171 cites W2900248192 @default.
- W4306784171 cites W2908966213 @default.
- W4306784171 cites W2911653212 @default.
- W4306784171 cites W2913005408 @default.
- W4306784171 cites W2914939061 @default.
- W4306784171 cites W2916100539 @default.
- W4306784171 cites W2921991537 @default.
- W4306784171 cites W2932111434 @default.
- W4306784171 cites W2939147787 @default.
- W4306784171 cites W2939862456 @default.
- W4306784171 cites W2945578795 @default.
- W4306784171 cites W2950463295 @default.
- W4306784171 cites W2955557725 @default.
- W4306784171 cites W2957637858 @default.
- W4306784171 cites W2969355077 @default.
- W4306784171 cites W2979138490 @default.
- W4306784171 cites W2985550165 @default.
- W4306784171 cites W2986219082 @default.
- W4306784171 cites W2988263178 @default.
- W4306784171 cites W2991669855 @default.
- W4306784171 cites W2994666581 @default.
- W4306784171 cites W3004561516 @default.
- W4306784171 cites W3004779294 @default.
- W4306784171 cites W3004782200 @default.
- W4306784171 cites W3005496161 @default.
- W4306784171 cites W3016192875 @default.
- W4306784171 cites W3020940024 @default.
- W4306784171 cites W3021794650 @default.
- W4306784171 cites W3023810643 @default.
- W4306784171 cites W3028673234 @default.
- W4306784171 cites W3029661147 @default.
- W4306784171 cites W3036599805 @default.
- W4306784171 cites W3039753020 @default.
- W4306784171 cites W3048404043 @default.
- W4306784171 cites W3082226944 @default.
- W4306784171 cites W3083572265 @default.
- W4306784171 cites W3087662819 @default.
- W4306784171 cites W3091507286 @default.
- W4306784171 cites W3092784158 @default.
- W4306784171 cites W3093471041 @default.