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- W4306794923 abstract "In case of violation of the technology of preparation and storage of feed, conditions are formed for development of fungi of the genus Aspergillus, Fusarium, etc., which often produce a diverse level of dangerous mycotoxins, leading to an increase in the number of cases of animal mycotoxicosis. The ingestion of mycotoxins into the body often causes a number of metabolic, physiological and immunological disorders. In the framework of this work, the effectiveness of a prophylactic mixture that combines components that affect a variety of pathological processes under conditions of combined exposure to mycotoxins was evaluated. White rats divided into 4 groups were used for the experiment. For 21 days, rats were fed with a mixture of mycotoxins (aflatoxin B1 - 2.5 mg/kg, T-2 toxin - 5 mg/kg, and zearalenone - 2.0 mg/kg). The negative effect of the combined act was demonstrated by the inhibition of the main metabolic parameters: a decrease in the concentration of total protein (32.8%), albumin (26.5%), globulin (42.2%), glucose (23.5%), an increase in the content of urea in blood serum (19.4%), the activity of hepatic aminotransferases: AST (32.5%) and ALT (29.6%), while in the group of rats that received toxic food with the addition of a prophylactic mixture, changes relative to the biological control group were 9.8, 9.1, 10.9, 9.5, 5.6, 11.3 and 8.33%, respectively, indicating a protective effect. The analysis of biochemical parameters was carried out on the ARD-200 analyzer. The protective effect of the mixture offered is also confirmed by the data of histological studies of the liver, as the main organ of mycotoxin metabolism. Thus, the addition of a prophylactic mixture based on nanoadsorbent, organic components, methionine and milk thistle meal (in an amount of 0.25% of the diet) showed a protective effect, which was expressed in the correlation of metabolic processes and less pronounced changes in the liver." @default.
- W4306794923 created "2022-10-20" @default.
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- W4306794923 date "2022-10-15" @default.
- W4306794923 modified "2023-10-14" @default.
- W4306794923 title "CHANGES IN INDIVIDUAL BIOCHEMICAL PARAMETERS AND HISTOLOGY OF THE LIVER OF WHITE RATS IN THE BACKGROUND OF THE APPLICATION OF A PREVENTIVE MIXTURE UNDER CONDITIONS OF EXPERIMENTAL MIXED MYCOTOXICOSIS" @default.
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- W4306794923 doi "https://doi.org/10.52419/issn2072-2419.2022.3.144" @default.
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