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- W4306795880 abstract "Premature adrenarche (PA) has been associated with an increase in adrenal androgens, and the hyperandrogenic hormonal environment is known to lead to increased platelet (PLT) aggregation. Here, we evaluated the effects of PA on PLT aggregation in PLT-rich plasma samples from female patients.The study included 40 female patients diagnosed with PA between February, 2014 and June, 2018 and 30 healthy female individuals as a control group. Adenosine diphosphate (ADP) and collagen-induced PLT aggregation were studied via the photometric aggregometry method.There were no significant differences in the PLT count or volume values between those participants with PA and the control group. Additionally, the ADP-induced maximum aggregation time, value, and slope values did not significantly differ between the patient and control groups (p>0.05). However, the collagen-induced maximum aggregation time, value, and slope values were significantly higher in the studygroup (p<0.001).Increased collagen-induced PLT aggregation was detected in female patients with PA. As PA is associated with a higher risk of cardiovascular events later in life, close follow-up of PA in this respect may be beneficial." @default.
- W4306795880 created "2022-10-20" @default.
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- W4306795880 date "2023-02-27" @default.
- W4306795880 modified "2023-09-24" @default.
- W4306795880 title "The Relationship Between Premature Adrenarche and Platelet Aggregation" @default.
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- W4306795880 doi "https://doi.org/10.4274/jcrpe.galenos.2022.2022-6-13" @default.
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