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- W4306800525 abstract "Hairpin/cruciform structures, as well as other non-B DNA structures, are important regulators for biological processes and gene function. The formation of these structures require that the DNA sequence contains adequately spaced inverted repeats. To study the potential of DNA regions to form hairpin/cruciform structures, we developed a new procedure to analyse the variation of the concentration of occurrence of inverted repeats at different spacings along the human genome. We apply the method to the human genome and identify regions with atypical high concentration of inverted repeats when compared to a control scenario based on a Markov model of order 7. We found that the potential to form hairpin/cruciform structures is very heterogeneous across different human genome regions. Also, different regions display strikingly different patterns of enrichment of concentration depending on inverted repeats spacing." @default.
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- W4306800525 date "2022-10-20" @default.
- W4306800525 modified "2023-10-14" @default.
- W4306800525 title "Genomic Regions with Atypical Concentration of Inverted Repeats" @default.
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- W4306800525 doi "https://doi.org/10.1007/978-3-031-17024-9_9" @default.
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