Matches in SemOpenAlex for { <https://semopenalex.org/work/W4306843032> ?p ?o ?g. }
- W4306843032 abstract "CCHamide-2 (CCHa2) is a protostome excitatory peptide ortholog known for various arthropod species. In fruit flies, CCHa2 plays a crucial role in the endocrine system, allowing peripheral tissue to communicate with the central nervous system to ensure proper development and the maintenance of energy homeostasis. Since the formation of odor-sugar associative long-term memory (LTM) depends on the nutrient status in an animal, CCHa2 may play an essential role in linking memory and metabolic systems. Here we show that CCHa2 signals are important for consolidating appetitive memory by acting on the rewarding dopamine neurons. Genetic disruption of CCHa2 using mutant strains abolished appetitive LTM but not short-term memory (STM). A post-learning thermal suppression of CCHa2 expressing cells impaired LTM. In contrast, a post-learning thermal activation of CCHa2 cells stabilized STM induced by non-nutritious sugar into LTM. The receptor of CCHa2, CCHa2-R, was expressed in a subset of dopamine neurons that mediate reward for LTM. In accordance, the receptor expression in these dopamine neurons was required for LTM specifically. We thus concluded that CCHa2 conveys a sugar nutrient signal to the dopamine neurons for memory consolidation. Our finding establishes a direct interplay between brain reward and the putative endocrine system for long-term energy homeostasis." @default.
- W4306843032 created "2022-10-20" @default.
- W4306843032 creator A5017294704 @default.
- W4306843032 creator A5021373150 @default.
- W4306843032 creator A5036219350 @default.
- W4306843032 creator A5037333176 @default.
- W4306843032 creator A5041059586 @default.
- W4306843032 creator A5059781308 @default.
- W4306843032 date "2022-10-19" @default.
- W4306843032 modified "2023-10-13" @default.
- W4306843032 title "Nutrient responding peptide hormone CCHamide-2 consolidates appetitive memory" @default.
- W4306843032 cites W1545856647 @default.
- W4306843032 cites W1691189977 @default.
- W4306843032 cites W1765882761 @default.
- W4306843032 cites W1824001463 @default.
- W4306843032 cites W1930392015 @default.
- W4306843032 cites W1963556856 @default.
- W4306843032 cites W1973987464 @default.
- W4306843032 cites W1974429130 @default.
- W4306843032 cites W1974768040 @default.
- W4306843032 cites W1978530827 @default.
- W4306843032 cites W1979893222 @default.
- W4306843032 cites W1985878549 @default.
- W4306843032 cites W1987135382 @default.
- W4306843032 cites W1987942547 @default.
- W4306843032 cites W1997522340 @default.
- W4306843032 cites W2018454554 @default.
- W4306843032 cites W2020051314 @default.
- W4306843032 cites W2025654941 @default.
- W4306843032 cites W2028791709 @default.
- W4306843032 cites W2034278075 @default.
- W4306843032 cites W2034840220 @default.
- W4306843032 cites W2050538855 @default.
- W4306843032 cites W2056266528 @default.
- W4306843032 cites W2059201383 @default.
- W4306843032 cites W2061484370 @default.
- W4306843032 cites W2065003229 @default.
- W4306843032 cites W2072500831 @default.
- W4306843032 cites W2086781637 @default.
- W4306843032 cites W2087484885 @default.
- W4306843032 cites W2088599563 @default.
- W4306843032 cites W2090527896 @default.
- W4306843032 cites W2092098765 @default.
- W4306843032 cites W2093534366 @default.
- W4306843032 cites W2117794907 @default.
- W4306843032 cites W2121610612 @default.
- W4306843032 cites W2161267789 @default.
- W4306843032 cites W2167279371 @default.
- W4306843032 cites W2168414233 @default.
- W4306843032 cites W2179301060 @default.
- W4306843032 cites W2219521484 @default.
- W4306843032 cites W2289570274 @default.
- W4306843032 cites W2297637412 @default.
- W4306843032 cites W2563147783 @default.
- W4306843032 cites W2567006593 @default.
- W4306843032 cites W2623936250 @default.
- W4306843032 cites W2670956404 @default.
- W4306843032 cites W2737405650 @default.
- W4306843032 cites W2769096023 @default.
- W4306843032 cites W2788647943 @default.
- W4306843032 cites W2790008006 @default.
- W4306843032 cites W2805127282 @default.
- W4306843032 cites W2805482788 @default.
- W4306843032 cites W2811420047 @default.
- W4306843032 cites W2884172681 @default.
- W4306843032 cites W2889329096 @default.
- W4306843032 cites W2890470934 @default.
- W4306843032 cites W2896692383 @default.
- W4306843032 cites W2897570668 @default.
- W4306843032 cites W2913620138 @default.
- W4306843032 cites W2923239445 @default.
- W4306843032 cites W2943353072 @default.
- W4306843032 cites W2957224081 @default.
- W4306843032 cites W2999465534 @default.
- W4306843032 cites W2999857418 @default.
- W4306843032 cites W3002232977 @default.
- W4306843032 cites W3041584383 @default.
- W4306843032 cites W3081916206 @default.
- W4306843032 cites W3087686918 @default.
- W4306843032 cites W3090328798 @default.
- W4306843032 cites W3094123565 @default.
- W4306843032 cites W3112375501 @default.
- W4306843032 cites W3117325545 @default.
- W4306843032 cites W3159072427 @default.
- W4306843032 cites W3161424202 @default.
- W4306843032 cites W3161978188 @default.
- W4306843032 cites W3169436287 @default.
- W4306843032 cites W3192725541 @default.
- W4306843032 cites W3204217818 @default.
- W4306843032 cites W3214141635 @default.
- W4306843032 cites W4210830393 @default.
- W4306843032 cites W4213219820 @default.
- W4306843032 cites W4220753140 @default.
- W4306843032 cites W4221075639 @default.
- W4306843032 cites W4239122357 @default.
- W4306843032 cites W4280633361 @default.
- W4306843032 cites W4281816910 @default.
- W4306843032 cites W877555498 @default.
- W4306843032 doi "https://doi.org/10.3389/fnbeh.2022.986064" @default.
- W4306843032 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36338876" @default.