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• W4306843896 abstract "To update the evidence of non-biological treatments for axial spondyloarthritis (axSpA), as a basis for the 2022 Assessment of SpondyloArthritis international Society-European Alliance of Associations for Rheumatology (ASAS-EULAR) recommendations for the management of axSpA.A systematic literature review (2016-2021) on efficacy and safety of non-pharmacological and non-biological pharmacological treatments was performed, up to 1 January 2022. The research question was formulated according to the PICO format: Population: adult patients with r-axSpA and nr-axSpA; Intervention: non-pharmacological and non-biological pharmacological treatments; Comparator: active comparator or placebo; Outcomes: all relevant efficacy and safety outcomes. Type of studies included were: randomised controlled trials (RCTs), observational studies (for efficacy of non-pharmacological treatments, and safety), qualitative studies. Cohen's effect size (ES) was calculated for non-pharmacological and risk ratio (RR) for pharmacological treatments.Of 107 publications included, 63 addressed non-pharmacological interventions, including education (n=8) and exercise (n=20). The ES for education on disease activity, function, mobility was small to moderate (eg. Bath Ankylosing Spondylitis Disease Activity Index (BASDAI), ES: 0.06-0.59). Exercise had moderate to high ES on these outcomes (eg.0.14-1.43). Six RCTs on targeted synthetic disease-modifying antirheumatic drugs (DMARDs) showed efficacy of tofacitinib, upadacitinib and filgotinib (phase 2 only) in r-axSpA (range RR vs placebo for ASAS20: 1.91-3.10), while apremilast and nilotinib were not efficacious. Studies on conventional synthetic DMARDs (n=3), non-steroidal anti-inflammatory drugs (NSAIDs, n=8) and other drugs (n=12) did not provide new evidence on efficacy/safety (efficacy of NSAIDs confirmed; limited efficacy of short-term glucocorticoids in one RCT).Education, exercise and NSAIDs confirmed to be efficacious in axSpA. JAKi were proved efficacious in r-axSpA." @default.
• W4306843896 created "2022-10-20" @default.
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• W4306843896 date "2022-10-19" @default.
• W4306843896 modified "2023-10-17" @default.
• W4306843896 title "Efficacy and safety of non-pharmacological and non-biological interventions: a systematic literature review informing the 2022 update of the ASAS/EULAR recommendations for the management of axial spondyloarthritis" @default.
• W4306843896 cites W1836409160 @default.
• W4306843896 cites W2038026781 @default.
• W4306843896 cites W2082977560 @default.
• W4306843896 cites W2122814783 @default.
• W4306843896 cites W2124551692 @default.
• W4306843896 cites W2290882705 @default.
• W4306843896 cites W2295138493 @default.
• W4306843896 cites W2298142026 @default.
• W4306843896 cites W2346015499 @default.
• W4306843896 cites W2404396320 @default.
• W4306843896 cites W2468968029 @default.
• W4306843896 cites W2493559804 @default.
• W4306843896 cites W2530826519 @default.
• W4306843896 cites W2534727496 @default.
• W4306843896 cites W2542842545 @default.
• W4306843896 cites W2543554814 @default.
• W4306843896 cites W2554626374 @default.
• W4306843896 cites W2560495069 @default.
• W4306843896 cites W2560809797 @default.
• W4306843896 cites W2572897530 @default.
• W4306843896 cites W2583030387 @default.
• W4306843896 cites W2594476110 @default.
• W4306843896 cites W2617806790 @default.
• W4306843896 cites W2626557154 @default.
• W4306843896 cites W2738144732 @default.
• W4306843896 cites W2739312681 @default.
• W4306843896 cites W2743321535 @default.
• W4306843896 cites W2748855470 @default.
• W4306843896 cites W2753978717 @default.
• W4306843896 cites W2754802448 @default.
• W4306843896 cites W2783743089 @default.
• W4306843896 cites W2788469268 @default.
• W4306843896 cites W2791311233 @default.
• W4306843896 cites W2799859874 @default.
• W4306843896 cites W2808818069 @default.
• W4306843896 cites W2809994819 @default.
• W4306843896 cites W2886407130 @default.
• W4306843896 cites W2895743434 @default.
• W4306843896 cites W2896552337 @default.
• W4306843896 cites W2896559962 @default.
• W4306843896 cites W2899780053 @default.
• W4306843896 cites W2903730404 @default.
• W4306843896 cites W2911716870 @default.
• W4306843896 cites W2918315198 @default.
• W4306843896 cites W2921809771 @default.
• W4306843896 cites W2925821620 @default.
• W4306843896 cites W2942680430 @default.
• W4306843896 cites W2945352003 @default.
• W4306843896 cites W2966440147 @default.
• W4306843896 cites W2970684805 @default.
• W4306843896 cites W2978608823 @default.
• W4306843896 cites W2983227134 @default.
• W4306843896 cites W2988532979 @default.
• W4306843896 cites W2988898563 @default.
• W4306843896 cites W2993436820 @default.
• W4306843896 cites W2993572480 @default.
• W4306843896 cites W2993616510 @default.
• W4306843896 cites W3000573092 @default.
• W4306843896 cites W3011061378 @default.
• W4306843896 cites W3014589264 @default.
• W4306843896 cites W3020894009 @default.
• W4306843896 cites W3021478935 @default.
• W4306843896 cites W3028633575 @default.
• W4306843896 cites W3037221535 @default.
• W4306843896 cites W3040890794 @default.
• W4306843896 cites W3048628479 @default.
• W4306843896 cites W3086125939 @default.
• W4306843896 cites W3091253249 @default.
• W4306843896 cites W3093163582 @default.
• W4306843896 cites W3094735393 @default.
• W4306843896 cites W3102763071 @default.
• W4306843896 cites W3119463521 @default.
• W4306843896 cites W3120843481 @default.
• W4306843896 cites W3122970268 @default.
• W4306843896 cites W3133803823 @default.
• W4306843896 cites W3134994822 @default.
• W4306843896 cites W3136890883 @default.
• W4306843896 cites W3157994245 @default.
• W4306843896 cites W3159177916 @default.
• W4306843896 cites W3160376151 @default.
• W4306843896 cites W3164989555 @default.
• W4306843896 cites W3165020695 @default.
• W4306843896 cites W3173474932 @default.
• W4306843896 cites W3178209221 @default.

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