FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4306851346> ?p ?o ?g. }

• W4306851346 endingPage "178" @default.
• W4306851346 startingPage "164" @default.
• W4306851346 abstract "Aminoglycosides are well known, cationic antimicrobial drugs. However, biofilm-based antibiotic resistance significantly limits their efficacy. Masking the polycationic character of these drugs, followed by incorporation into self-emulsifying drug delivery systems (SEDDS) can improve biofilm eradication.Imine derivatives were synthesized via coupling with trans-cinnamaldehyde and characterized regarding degree of substitution, logP, cytotoxicity and antimicrobial efficacy on the opportunistic human pathogens Escherichia coli, Staphylococcus aureus and Candida albicans. Imines were loaded into newly developed SEDDS formulations and the antimicrobial efficacy was assessed on these pathogens in planktonic state and after biofilm formation.Successful synthesis of imine derivatives with almost entirely masked amine groups was confirmed by NMR, FT-IR, TLC and MS. Imines exhibited a marked elevation in logP value of 8 units for kanamycin and 7.7 units for tobramycin. They showed low toxicity profiles while fully preserving antimicrobial efficacy on all tested pathogens. Incorporation into SEDDS resulted in nanoemulsions, which exhibited equal antimicrobial efficacy on the model germs compared to the corresponding aminoglycosides. Moreover, the biofilm eradication assay revealed superior anti-biofilm properties of the nanoemulsions. Native aminoglycosides were largely prone to reduced microbial susceptibility due to biofilm formation, while the combination of SEDDS with iminated aminoglycosides provided overall enhanced biofilm eradication." @default.
• W4306851346 created "2022-10-20" @default.
• W4306851346 creator A5005875043 @default.
• W4306851346 creator A5020088354 @default.
• W4306851346 creator A5035632031 @default.
• W4306851346 creator A5039522067 @default.
• W4306851346 creator A5046581067 @default.
• W4306851346 creator A5046872153 @default.
• W4306851346 creator A5048277918 @default.
• W4306851346 date "2023-01-01" @default.
• W4306851346 modified "2023-10-13" @default.
• W4306851346 title "Iminated aminoglycosides in self-emulsifying drug delivery systems: Dual approach to break down the microbial defense" @default.
• W4306851346 cites W1575182689 @default.
• W4306851346 cites W1970890798 @default.
• W4306851346 cites W1985656532 @default.
• W4306851346 cites W1992000185 @default.
• W4306851346 cites W1996064131 @default.
• W4306851346 cites W2001194276 @default.
• W4306851346 cites W2020701688 @default.
• W4306851346 cites W2021198360 @default.
• W4306851346 cites W2032808656 @default.
• W4306851346 cites W2035418839 @default.
• W4306851346 cites W2048735310 @default.
• W4306851346 cites W2056995570 @default.
• W4306851346 cites W2068853726 @default.
• W4306851346 cites W2069168271 @default.
• W4306851346 cites W2072589601 @default.
• W4306851346 cites W2074822656 @default.
• W4306851346 cites W2083311051 @default.
• W4306851346 cites W2103455329 @default.
• W4306851346 cites W2106652574 @default.
• W4306851346 cites W2107794472 @default.
• W4306851346 cites W2109733963 @default.
• W4306851346 cites W2112487247 @default.
• W4306851346 cites W2124122605 @default.
• W4306851346 cites W2132911648 @default.
• W4306851346 cites W2134470555 @default.
• W4306851346 cites W2159149748 @default.
• W4306851346 cites W2161687494 @default.
• W4306851346 cites W2171720299 @default.
• W4306851346 cites W2185564569 @default.
• W4306851346 cites W2410959088 @default.
• W4306851346 cites W2415139757 @default.
• W4306851346 cites W2460460441 @default.
• W4306851346 cites W2568035168 @default.
• W4306851346 cites W2571419689 @default.
• W4306851346 cites W2587002903 @default.
• W4306851346 cites W2603755876 @default.
• W4306851346 cites W2739674022 @default.
• W4306851346 cites W2765773027 @default.
• W4306851346 cites W2768518682 @default.
• W4306851346 cites W2778539107 @default.
• W4306851346 cites W2790516073 @default.
• W4306851346 cites W2801978353 @default.
• W4306851346 cites W2805883398 @default.
• W4306851346 cites W2899860726 @default.
• W4306851346 cites W2949138741 @default.
• W4306851346 cites W2969242303 @default.
• W4306851346 cites W2984247274 @default.
• W4306851346 cites W3048576806 @default.
• W4306851346 cites W3111326421 @default.
• W4306851346 cites W3137503718 @default.
• W4306851346 cites W3172955221 @default.
• W4306851346 cites W3185903970 @default.
• W4306851346 cites W3187158005 @default.
• W4306851346 cites W3216480155 @default.
• W4306851346 cites W4221134663 @default.
• W4306851346 cites W4230476415 @default.
• W4306851346 cites W4288458004 @default.
• W4306851346 cites W86119692 @default.
• W4306851346 doi "https://doi.org/10.1016/j.jcis.2022.10.077" @default.
• W4306851346 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36327720" @default.
• W4306851346 hasPublicationYear "2023" @default.
• W4306851346 type Work @default.
• W4306851346 citedByCount "2" @default.
• W4306851346 countsByYear W43068513462023 @default.
• W4306851346 crossrefType "journal-article" @default.
• W4306851346 hasAuthorship W4306851346A5005875043 @default.
• W4306851346 hasAuthorship W4306851346A5020088354 @default.
• W4306851346 hasAuthorship W4306851346A5035632031 @default.
• W4306851346 hasAuthorship W4306851346A5039522067 @default.
• W4306851346 hasAuthorship W4306851346A5046581067 @default.
• W4306851346 hasAuthorship W4306851346A5046872153 @default.
• W4306851346 hasAuthorship W4306851346A5048277918 @default.
• W4306851346 hasBestOaLocation W43068513461 @default.
• W4306851346 hasConcept C185592680 @default.
• W4306851346 hasConcept C2778400546 @default.
• W4306851346 hasConcept C2780917455 @default.
• W4306851346 hasConcept C4937899 @default.
• W4306851346 hasConcept C523546767 @default.
• W4306851346 hasConcept C54355233 @default.
• W4306851346 hasConcept C58123911 @default.
• W4306851346 hasConcept C86803240 @default.
• W4306851346 hasConcept C89423630 @default.
• W4306851346 hasConceptScore W4306851346C185592680 @default.
• W4306851346 hasConceptScore W4306851346C2778400546 @default.
• W4306851346 hasConceptScore W4306851346C2780917455 @default.
• W4306851346 hasConceptScore W4306851346C4937899 @default.

• next