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• W4306869215 abstract "Posaconazole is often used for the prophylaxis and treatment of invasive fungal infections (IFI). However, intra- and inter-individual differences and drug interactions affect the efficacy and safety of posaconazole. Precision dosing of posaconazole based on the population pharmacokinetic (PopPK) model may assist in making significant clinical decisions. This review aimed to comprehensively summarize the published PopPK models of posaconazole and analyze covariates that significantly influence posaconazole exposure. Articles published until May 2022 for PopPK analysis of posaconazole were searched in PubMed and EMBASE databases. Demographic characteristics, model characteristics, and results of PopPK analysis were extracted from the selected articles. In addition, the steady-state pharmacokinetic profiles of posaconazole were simulated at different covariate levels and dosing regimens. Out of the 13 studies included in our review, nine studies included adults, three included children, and one included both adults and children. All oral administration models were one-compartment models, and all intravenous administration models were two-compartment models. Body weight, proton pump inhibitors, and incidence of diarrhea were found to be important covariates. Clinically, the potential impact of factors such as patient physiopathologic characteristics and comorbid medications on posaconazole pharmacokinetics should be considered. Dose adjustment in combination with TDM or replacement with a tablet or intravenous formulation with higher exposure may be an effective way to ensure drug efficacy as well as to reduce fungal resistance. Meanwhile, published models require further external evaluation to examine extrapolation." @default.
• W4306869215 created "2022-10-20" @default.
• W4306869215 creator A5002350440 @default.
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• W4306869215 creator A5030939361 @default.
• W4306869215 creator A5032939434 @default.
• W4306869215 creator A5046787262 @default.
• W4306869215 date "2022-10-01" @default.
• W4306869215 modified "2023-10-18" @default.
• W4306869215 title "A Review of Population Pharmacokinetic Models of Posaconazole" @default.
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• W4306869215 doi "https://doi.org/10.2147/dddt.s384637" @default.
• W4306869215 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36277600" @default.
• W4306869215 hasPublicationYear "2022" @default.
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