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- W4306873777 endingPage "1547" @default.
- W4306873777 startingPage "1536" @default.
- W4306873777 abstract "Parkinson's disease (PD) is one of the most common neurodegenerative diseases, characterized by the reduction of dopamine neurons in the substantia nigra. Levodopa, as a dopamine supplement, is the gold-standard therapeutic drug for PD. The metabolism of levodopa in the periphery not only decreases its bioavailability but also affects its efficacy. Thus, it is necessary to investigate how levodopa is metabolized. A growing number of studies have shown that intestinal bacteria, such as Enterococcus faecalis, Eggerthella lenta and Clostridium sporogenes, could metabolize levodopa in different ways. In addition, several pathways to reduce levodopa metabolism by gut microbiota were confirmed to improve levodopa efficacy. These pathways include aromatic amino acid decarboxylase (AADC) inhibitors, antibiotics, pH and (S)-α-fluoromethyltyrosine (AFMT). In this review, we have summarized the metabolic process of levodopa by intestinal bacteria and analyzed potential approaches to reduce the metabolism of levodopa by gut microbiota, thus improving the efficacy of levodopa." @default.
- W4306873777 created "2022-10-20" @default.
- W4306873777 creator A5036283981 @default.
- W4306873777 creator A5052274720 @default.
- W4306873777 creator A5078519780 @default.
- W4306873777 date "2023-07-01" @default.
- W4306873777 modified "2023-10-16" @default.
- W4306873777 title "Relationship Between Gut Bacteria and Levodopa Metabolism" @default.
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