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- W4306874701 abstract "Background: Preclinical studies suggest that senolytic compounds such as quercetin (a natural product) and dasatinib (a synthetic product) decrease senescent cells, reduce inflammation, and alleviate human frailty. This evidence has opened a new field of research for studying the effect of these compounds on age-related dysfunction and diseases. Objective: The present study performed in silico and we identified new potential senolytic candidates from an extensive database that contains natural products (NPs) and semi-synthetic products (SMSs). Methods: Computer programs Chemminer and rcdk packages, which compared the fingerprints of numerous molecules (40,383) with reference senolytics, and the creation of a pharmacological network built with signaling pathways and targets involved in senescence processes were used to identify compounds with a potential activity. Results: Six drug-like candidates (3,4'-dihydroxypropiophenone, baicalein, α, β-dehydrocurvularin, lovastatin, luteolin, and phloretin) were identified. Conclusion: To our knowledge, this is the first time that these six natural molecules have been proposed to have senolytic activity. To validate the methodology employed in the identification of new drug-like senolytics, experimental evidence is needed with models that evaluate senolytic activity." @default.
- W4306874701 created "2022-10-20" @default.
- W4306874701 creator A5026035807 @default.
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- W4306874701 date "2023-08-01" @default.
- W4306874701 modified "2023-10-02" @default.
- W4306874701 title "Natural Products as a Major Source of Candidates for Potential Senolytic Compounds obtained by in silico Screening" @default.
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- W4306874701 doi "https://doi.org/10.2174/1573406419666221019153537" @default.
- W4306874701 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36278464" @default.
- W4306874701 hasPublicationYear "2023" @default.
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