Matches in SemOpenAlex for { <https://semopenalex.org/work/W4306926048> ?p ?o ?g. }
- W4306926048 endingPage "12622" @default.
- W4306926048 startingPage "12622" @default.
- W4306926048 abstract "Retinoids are natural and synthetic vitamin A derivatives that are effective for the prevention and the treatment of non-melanoma skin cancers (NMSC). NMSCs constitute a heterogenous group of non-melanocyte-derived skin cancers that impose substantial burdens on patients and healthcare systems. They include entities such as basal cell carcinoma and cutaneous squamous cell carcinoma (collectively called keratinocyte carcinomas), cutaneous lymphomas and Kaposi's sarcoma among others. The retinoid signaling pathway plays influential roles in skin physiology and pathology. These compounds regulate diverse biological processes within the skin, including proliferation, differentiation, angiogenesis and immune regulation. Collectively, retinoids can suppress skin carcinogenesis. Both topical and systemic retinoids have been investigated in clinical trials as NMSC prophylactics and treatments. Desirable efficacy and tolerability in clinical trials have prompted health regulatory bodies to approve the use of retinoids for NMSC management. Acceptable off-label uses of these compounds as drugs for skin cancers are also described. This review is a comprehensive outline on the biochemistry of retinoids, their activities in the skin, their effects on cancer cells and their adoption in clinical practice." @default.
- W4306926048 created "2022-10-21" @default.
- W4306926048 creator A5006091749 @default.
- W4306926048 creator A5018191360 @default.
- W4306926048 creator A5058387312 @default.
- W4306926048 creator A5060312875 @default.
- W4306926048 creator A5066639630 @default.
- W4306926048 creator A5077951384 @default.
- W4306926048 creator A5086404931 @default.
- W4306926048 creator A5090193087 @default.
- W4306926048 date "2022-10-20" @default.
- W4306926048 modified "2023-10-15" @default.
- W4306926048 title "The Use of Retinoids for the Prevention and Treatment of Skin Cancers: An Updated Review" @default.
- W4306926048 cites W1505967068 @default.
- W4306926048 cites W1580003303 @default.
- W4306926048 cites W159580356 @default.
- W4306926048 cites W1605238777 @default.
- W4306926048 cites W1610996721 @default.
- W4306926048 cites W1622461349 @default.
- W4306926048 cites W1832821854 @default.
- W4306926048 cites W1897204191 @default.
- W4306926048 cites W1928973808 @default.
- W4306926048 cites W1940921800 @default.
- W4306926048 cites W1963500695 @default.
- W4306926048 cites W1964100132 @default.
- W4306926048 cites W1964376876 @default.
- W4306926048 cites W1964422508 @default.
- W4306926048 cites W1964526720 @default.
- W4306926048 cites W1964686560 @default.
- W4306926048 cites W1966825695 @default.
- W4306926048 cites W1968876115 @default.
- W4306926048 cites W1973666901 @default.
- W4306926048 cites W1973697421 @default.
- W4306926048 cites W1973727936 @default.
- W4306926048 cites W1974804888 @default.
- W4306926048 cites W1975127503 @default.
- W4306926048 cites W1975208051 @default.
- W4306926048 cites W1976299093 @default.
- W4306926048 cites W1977848775 @default.
- W4306926048 cites W1978411073 @default.
- W4306926048 cites W1980619160 @default.
- W4306926048 cites W1981135369 @default.
- W4306926048 cites W1984033355 @default.
- W4306926048 cites W1985804036 @default.
- W4306926048 cites W1985964388 @default.
- W4306926048 cites W1986419116 @default.
- W4306926048 cites W1986558277 @default.
- W4306926048 cites W1986671668 @default.
- W4306926048 cites W1987077565 @default.
- W4306926048 cites W1987144012 @default.
- W4306926048 cites W1988207010 @default.
- W4306926048 cites W1988698239 @default.
- W4306926048 cites W1990218144 @default.
- W4306926048 cites W1990872736 @default.
- W4306926048 cites W1991724354 @default.
- W4306926048 cites W1992329875 @default.
- W4306926048 cites W1993366417 @default.
- W4306926048 cites W1993569116 @default.
- W4306926048 cites W1993917786 @default.
- W4306926048 cites W1994578749 @default.
- W4306926048 cites W1994809932 @default.
- W4306926048 cites W1995364290 @default.
- W4306926048 cites W1996098672 @default.
- W4306926048 cites W1998732171 @default.
- W4306926048 cites W1999740475 @default.
- W4306926048 cites W2000477644 @default.
- W4306926048 cites W2001563626 @default.
- W4306926048 cites W2004170652 @default.
- W4306926048 cites W2004825203 @default.
- W4306926048 cites W2006003235 @default.
- W4306926048 cites W2006491285 @default.
- W4306926048 cites W2007600985 @default.
- W4306926048 cites W2008583255 @default.
- W4306926048 cites W2009773728 @default.
- W4306926048 cites W2009869746 @default.
- W4306926048 cites W2011621212 @default.
- W4306926048 cites W2011969411 @default.
- W4306926048 cites W2013181939 @default.
- W4306926048 cites W2013626469 @default.
- W4306926048 cites W2014571799 @default.
- W4306926048 cites W2015219861 @default.
- W4306926048 cites W2015404822 @default.
- W4306926048 cites W2016299336 @default.
- W4306926048 cites W2018301226 @default.
- W4306926048 cites W2018641530 @default.
- W4306926048 cites W2018740809 @default.
- W4306926048 cites W2019736888 @default.
- W4306926048 cites W2019887014 @default.
- W4306926048 cites W2020327343 @default.
- W4306926048 cites W2022633251 @default.
- W4306926048 cites W2023660173 @default.
- W4306926048 cites W2023871558 @default.
- W4306926048 cites W2025025945 @default.
- W4306926048 cites W2030675083 @default.
- W4306926048 cites W2030796649 @default.
- W4306926048 cites W2030888198 @default.
- W4306926048 cites W2031363300 @default.
- W4306926048 cites W2031551895 @default.