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- W4306926049 endingPage "12592" @default.
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- W4306926049 abstract "The mineralocorticoid receptor (MR) is a member of the steroid receptor family and acts as a ligand-dependent transcription factor. In addition to its classical effects on water and electrolyte balance, its involvement in the pathogenesis of cardiovascular and renal diseases has been the subject of research for several years. The molecular basis of the latter has not been fully elucidated, but an isolated increase in the concentration of the MR ligand aldosterone or MR expression does not suffice to explain long-term pathologic actions of the receptor. Several studies suggest that MR activity and signal transduction are modulated by the surrounding microenvironment, which therefore plays an important role in MR pathophysiological effects. Local changes in micromilieu, including hypoxia, ischemia/reperfusion, inflammation, radical stress, and aberrant salt or glucose concentrations affect MR activation and therefore may influence the probability of unphysiological MR actions. The surrounding micromilieu may modulate genomic MR activity either by causing changes in MR expression or MR activity; for example, by inducing posttranslational modifications of the MR or novel interaction with coregulators, DNA-binding sites, or non-classical pathways. This should be considered when developing treatment options and strategies for prevention of MR-associated diseases." @default.
- W4306926049 created "2022-10-21" @default.
- W4306926049 creator A5001499625 @default.
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- W4306926049 creator A5040800736 @default.
- W4306926049 creator A5086483152 @default.
- W4306926049 date "2022-10-20" @default.
- W4306926049 modified "2023-10-09" @default.
- W4306926049 title "Importance of Micromilieu for Pathophysiologic Mineralocorticoid Receptor Activity—When the Mineralocorticoid Receptor Resides in the Wrong Neighborhood" @default.
- W4306926049 cites W137431462 @default.
- W4306926049 cites W1485915558 @default.
- W4306926049 cites W1595822167 @default.
- W4306926049 cites W1770024411 @default.
- W4306926049 cites W1817639972 @default.
- W4306926049 cites W1964681516 @default.
- W4306926049 cites W1965783061 @default.
- W4306926049 cites W1966030580 @default.
- W4306926049 cites W1967783942 @default.
- W4306926049 cites W1972026365 @default.
- W4306926049 cites W1974312109 @default.
- W4306926049 cites W1975210189 @default.
- W4306926049 cites W1975538620 @default.
- W4306926049 cites W1976244241 @default.
- W4306926049 cites W1981384991 @default.
- W4306926049 cites W1982177470 @default.
- W4306926049 cites W1982283178 @default.
- W4306926049 cites W1983234392 @default.
- W4306926049 cites W1984347108 @default.
- W4306926049 cites W1990001636 @default.
- W4306926049 cites W1992602878 @default.
- W4306926049 cites W1993471045 @default.
- W4306926049 cites W1993704473 @default.
- W4306926049 cites W1998793050 @default.
- W4306926049 cites W1999921360 @default.
- W4306926049 cites W2008097557 @default.
- W4306926049 cites W2017446057 @default.
- W4306926049 cites W2020596565 @default.
- W4306926049 cites W2022313401 @default.
- W4306926049 cites W2026570544 @default.
- W4306926049 cites W2026956603 @default.
- W4306926049 cites W2027386525 @default.
- W4306926049 cites W2028158855 @default.
- W4306926049 cites W2028235817 @default.
- W4306926049 cites W2028262137 @default.
- W4306926049 cites W2029354142 @default.
- W4306926049 cites W2032277315 @default.
- W4306926049 cites W2035140438 @default.
- W4306926049 cites W2037481669 @default.
- W4306926049 cites W2039908108 @default.
- W4306926049 cites W2041953777 @default.
- W4306926049 cites W2044561526 @default.
- W4306926049 cites W2046298859 @default.
- W4306926049 cites W2047860442 @default.
- W4306926049 cites W2047908219 @default.
- W4306926049 cites W2048813075 @default.
- W4306926049 cites W2049050811 @default.
- W4306926049 cites W2049772614 @default.
- W4306926049 cites W2050263292 @default.
- W4306926049 cites W2050515820 @default.
- W4306926049 cites W2051386984 @default.
- W4306926049 cites W2051923922 @default.
- W4306926049 cites W2055496662 @default.
- W4306926049 cites W2062134402 @default.
- W4306926049 cites W2063800517 @default.
- W4306926049 cites W2075323044 @default.
- W4306926049 cites W2080080632 @default.
- W4306926049 cites W2091304259 @default.
- W4306926049 cites W2092312413 @default.
- W4306926049 cites W2093131177 @default.
- W4306926049 cites W2093901402 @default.
- W4306926049 cites W2094354488 @default.
- W4306926049 cites W2095970557 @default.
- W4306926049 cites W2096158094 @default.
- W4306926049 cites W2098584422 @default.
- W4306926049 cites W2101787540 @default.
- W4306926049 cites W2106052194 @default.
- W4306926049 cites W2108602400 @default.
- W4306926049 cites W2109341154 @default.
- W4306926049 cites W2109560663 @default.
- W4306926049 cites W2109689484 @default.
- W4306926049 cites W2111693605 @default.
- W4306926049 cites W2112099666 @default.
- W4306926049 cites W2112815475 @default.
- W4306926049 cites W2113511490 @default.
- W4306926049 cites W2122696753 @default.
- W4306926049 cites W2124370258 @default.
- W4306926049 cites W2127867654 @default.
- W4306926049 cites W2130102570 @default.
- W4306926049 cites W2130935095 @default.
- W4306926049 cites W2131715702 @default.
- W4306926049 cites W2131888544 @default.
- W4306926049 cites W2131978458 @default.
- W4306926049 cites W2138202420 @default.
- W4306926049 cites W2140811295 @default.
- W4306926049 cites W2140949602 @default.
- W4306926049 cites W2141686420 @default.
- W4306926049 cites W2147368542 @default.