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• W4306932519 endingPage "108685" @default.
• W4306932519 startingPage "108685" @default.
• W4306932519 abstract "During the construction of tissue-engineered bone in vitro , bionic mechanical stimulation has been considered to be critical to cellular response and bone tissue formation. Bone mesenchymal stem cells (BMSCs) at different osteogenesis phases in the bone marrow cavity are subjected to fluid shear stress (FSS). However, the responses of BMSCs at different phases of osteogenic differentiation to FSS remain unknown. Therefore, FSS was applied to BMSCs at different osteogenesis phases in vitro by parallel plate flow chamber, and the osteogenic ability and underlying related mechanisms were explored. Our study showed that BMSCs underwent rapid proliferation, early matrix maturity and late mineralization phases at 1, 7 and 14 days of osteogenic induction, respectively. FSS significantly promoted the osteogenic differentiation of BMSCs at early matrix maturation phase. Applying FSS on BMSCs at early matrix maturity phase resulted in significant remodeling of F-actin, forming of stress fibers, and the transduction of mechanical signal by the cytoskeleton-Lamin A pathway. Through the interaction between Lamin A and Methyltransferase-like 3 (METTL3), the levels of METTL3 protein and the m6A methylation genes were increased, promoting the osteoblastic differentiation of BMSCs. The results provided a new insight for the construction of bone tissue in vitro and the treatment strategy of bone defects. The data used to support the findings of this study are available from the corresponding author upon request. • FSS significantly promoted the osteogenic differentiation of BMSCs at early matrix maturation phase. • The interaction between Lamin A and METTL3 was demonstrated in BMSCs. • METTL3 mediated osteogenic differentiation of BMSC at early matrix maturation phase induced by FSS." @default.
• W4306932519 created "2022-10-21" @default.
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• W4306932519 date "2022-12-01" @default.
• W4306932519 modified "2023-09-27" @default.
• W4306932519 title "Fluid shear stress promotes osteogenesis of bone mesenchymal stem cells at early matrix maturity phase through Lamin A/ METTL3 signal axis" @default.
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• W4306932519 doi "https://doi.org/10.1016/j.bej.2022.108685" @default.
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