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• W4306936858 endingPage "7100" @default.
• W4306936858 startingPage "7100" @default.
• W4306936858 abstract "Alzheimer's disease is a neurodegenerative disease characterized by progressive memory loss and cognitive impairment due to a severe loss of cholinergic neurons in specific brain areas. It is the most common type of dementia in the aging population. Although many anti-acetylcholinesterase (AChE) drugs are already available on the market, their performance sometimes yields unexpected results. For this reason, research works are ongoing to find potential anti-AChE agents both from natural and synthetic sources. In this study, 90 extracts from 30 native and naturalized medicinal plants are tested by TLC and Ellman's colorimetric assay at 250, 125 and 62.5 μg/mL in order to determine the inhibitory effect on AChE. In total, 21 out of 90 extracts show high anti-AChE activity (75-100% inhibition) in a dose-dependent manner. Among them, ethanolic extract from aerial parts of O. vulgare ssp. vulgare shows an IC50 value 7.7 times lower than galantamine. This research also establishes the chemical profile of oregano extract by TLC, HPLC-DAD and LC-MS, and twenty-three compounds are identified and quantified. Dihydroxycinnamic acids and flavonoids are the most abundant ones (56.90 and 25.94%, respectively). Finally, total phenolic compounds and antioxidant properties are quantified by colorimetric methods. The total phenolic content is 207.64 ± 0.69 µg/mg of extract. The antioxidant activity is measured against two radicals, DPPH and ABTS. In both assays, the oregano extract shows high activity. The Pearson correlation matrix shows the relationship between syringic acids, a type of dihydroxybenzoic acid, and anti-AChE (r2 = -0.9864) and antioxidant activity (r2 = 0.9409 and 0.9976). In conclusion, the results of this study demonstrate promising potential new uses of these medicinal herbs for the treatment of Alzheimer's. Origanum vulgare ssp. vulgare and syringic acids, which have anti-AChE activity and beneficial antioxidant capacity, can be highlighted as potential candidates for the development of drugs for the treatment of Alzheimer's disease and other diseases characterized by a cholinergic deficit." @default.
• W4306936858 created "2022-10-21" @default.
• W4306936858 creator A5036315566 @default.
• W4306936858 creator A5037483529 @default.
• W4306936858 creator A5077127977 @default.
• W4306936858 date "2022-10-20" @default.
• W4306936858 modified "2023-10-18" @default.
• W4306936858 title "Anticholinesterase Activity of Selected Medicinal Plants from Navarra Region of Spain and a Detailed Phytochemical Investigation of Origanum vulgare L. ssp. vulgare" @default.
• W4306936858 cites W1133079448 @default.
• W4306936858 cites W1424721602 @default.
• W4306936858 cites W1452442842 @default.
• W4306936858 cites W1532166610 @default.
• W4306936858 cites W1876746804 @default.
• W4306936858 cites W1917515069 @default.
• W4306936858 cites W1968285444 @default.
• W4306936858 cites W1971248888 @default.
• W4306936858 cites W1973826463 @default.
• W4306936858 cites W1980517973 @default.
• W4306936858 cites W1981615081 @default.
• W4306936858 cites W1984008900 @default.
• W4306936858 cites W1987204546 @default.
• W4306936858 cites W1990064402 @default.
• W4306936858 cites W1991226856 @default.
• W4306936858 cites W1997984997 @default.
• W4306936858 cites W1999134783 @default.
• W4306936858 cites W2001061645 @default.
• W4306936858 cites W2001359884 @default.
• W4306936858 cites W2003332481 @default.
• W4306936858 cites W2012661809 @default.
• W4306936858 cites W2014923793 @default.
• W4306936858 cites W2020085406 @default.
• W4306936858 cites W2023670754 @default.
• W4306936858 cites W2024992930 @default.
• W4306936858 cites W2027659326 @default.
• W4306936858 cites W2030609239 @default.
• W4306936858 cites W2039697813 @default.
• W4306936858 cites W2043160969 @default.
• W4306936858 cites W2044638222 @default.
• W4306936858 cites W2048322642 @default.
• W4306936858 cites W2048647473 @default.
• W4306936858 cites W2058851810 @default.
• W4306936858 cites W2059377071 @default.
• W4306936858 cites W2061846546 @default.
• W4306936858 cites W2062797062 @default.
• W4306936858 cites W2064299673 @default.
• W4306936858 cites W2065853716 @default.
• W4306936858 cites W2071364419 @default.
• W4306936858 cites W2074076862 @default.
• W4306936858 cites W2075161294 @default.
• W4306936858 cites W2077767418 @default.
• W4306936858 cites W2079964677 @default.
• W4306936858 cites W2079977910 @default.
• W4306936858 cites W2080875615 @default.
• W4306936858 cites W2081085034 @default.
• W4306936858 cites W2082213920 @default.
• W4306936858 cites W2083723131 @default.
• W4306936858 cites W2083751708 @default.
• W4306936858 cites W2086748277 @default.
• W4306936858 cites W2090315542 @default.
• W4306936858 cites W2090681646 @default.
• W4306936858 cites W2092829298 @default.
• W4306936858 cites W2092865280 @default.
• W4306936858 cites W2103640428 @default.
• W4306936858 cites W2147415725 @default.
• W4306936858 cites W2161531875 @default.
• W4306936858 cites W2162049889 @default.
• W4306936858 cites W2165201727 @default.
• W4306936858 cites W2165219148 @default.
• W4306936858 cites W2169332865 @default.
• W4306936858 cites W2187704586 @default.
• W4306936858 cites W2221037922 @default.
• W4306936858 cites W2331640373 @default.
• W4306936858 cites W2407480728 @default.
• W4306936858 cites W2440980609 @default.
• W4306936858 cites W2483736282 @default.
• W4306936858 cites W2511346408 @default.
• W4306936858 cites W2523001295 @default.
• W4306936858 cites W2545062255 @default.
• W4306936858 cites W2561857005 @default.
• W4306936858 cites W2567321162 @default.
• W4306936858 cites W2767980419 @default.
• W4306936858 cites W2775829552 @default.
• W4306936858 cites W2778090033 @default.
• W4306936858 cites W2783485845 @default.
• W4306936858 cites W2789479247 @default.
• W4306936858 cites W2793396768 @default.
• W4306936858 cites W2885251771 @default.
• W4306936858 cites W2887115678 @default.
• W4306936858 cites W2888924355 @default.
• W4306936858 cites W2890553082 @default.
• W4306936858 cites W2893219057 @default.
• W4306936858 cites W2893930979 @default.
• W4306936858 cites W2903295613 @default.
• W4306936858 cites W2906519833 @default.
• W4306936858 cites W2921998209 @default.
• W4306936858 cites W2945088347 @default.
• W4306936858 cites W2956635503 @default.
• W4306936858 cites W2957479918 @default.

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