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• W4306938568 startingPage "1445" @default.
• W4306938568 abstract "The ability of polymyxin B, an antibiotic used to treat infections caused by multidrug-resistant Gram-negative bacteria as a last-line therapeutic option, to form ion pores in model membranes composed of various phospholipids and lipopolysaccharides was studied. Our data demonstrate that polymyxin B predominantly interacts with negatively charged lipids. Susceptibility decreases as follows: Kdo2-Lipid A >> DOPG ≈ DOPS >> DPhPG ≈ TOCL ≈ Lipid A. The dimer and hexamer of polymyxin B are involved in the pore formation in DOPG(DOPS)- and Kdo2-Lipid A-enriched bilayers, respectively. The pore-forming ability of polymyxin B significantly depends on the shape of membrane lipids, which indicates that the antibiotic produces toroidal lipopeptide-lipid pores. Small amphiphilic molecules diminishing the membrane dipole potential and inducing positive curvature stress were shown to be agonists of pore formation by polymyxin B and might be used to develop innovative lipopeptide-based formulations." @default.
• W4306938568 created "2022-10-21" @default.
• W4306938568 creator A5008706887 @default.
• W4306938568 creator A5050884215 @default.
• W4306938568 creator A5073494767 @default.
• W4306938568 date "2022-10-20" @default.
• W4306938568 modified "2023-09-26" @default.
• W4306938568 title "Lipid Microenvironment Modulates the Pore-Forming Ability of Polymyxin B" @default.
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• W4306938568 doi "https://doi.org/10.3390/antibiotics11101445" @default.
• W4306938568 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36290103" @default.
• W4306938568 hasPublicationYear "2022" @default.
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