Matches in SemOpenAlex for { <https://semopenalex.org/work/W4306952671> ?p ?o ?g. }
- W4306952671 endingPage "624" @default.
- W4306952671 startingPage "607" @default.
- W4306952671 abstract "Lung related disorders like COPD and Asthma, as well as various infectious diseases, form a major therapeutic area which would benefit from a predictive and adaptable mathematical model for describing pulmonary disposition of biological modalities. In this study we fill that gap by extending the cross-species two-pore physiologically-based pharmacokinetic (PBPK) platform with more detailed respiratory tract that includes the airways and alveolar space with epithelial lining fluid. We parameterize the paracellular and FcRn-facilitated exchange pathways between the epithelial lining fluid and lung interstitial space by building a mechanistic model for the exchange between the two. The optimized two-pore PBPK model described pulmonary exposure of several systemically dosed mAbs for which data is available and is also in agreement with the observed levels of endogenous IgG and albumin. The proposed framework can be used to assess pharmacokinetics of new lung-targeting biologic therapies and guide their dosing to achieve desired exposure at the pulmonary site-of-action." @default.
- W4306952671 created "2022-10-21" @default.
- W4306952671 creator A5030877212 @default.
- W4306952671 creator A5072351058 @default.
- W4306952671 creator A5073950498 @default.
- W4306952671 date "2022-10-20" @default.
- W4306952671 modified "2023-10-14" @default.
- W4306952671 title "Physiologically-based pharmacokinetic model for pulmonary disposition of protein therapeutics in humans" @default.
- W4306952671 cites W1709830154 @default.
- W4306952671 cites W1911086161 @default.
- W4306952671 cites W1929182612 @default.
- W4306952671 cites W1964661913 @default.
- W4306952671 cites W1966465047 @default.
- W4306952671 cites W1981730803 @default.
- W4306952671 cites W1993403034 @default.
- W4306952671 cites W1996045402 @default.
- W4306952671 cites W2002765161 @default.
- W4306952671 cites W2007770546 @default.
- W4306952671 cites W2019188597 @default.
- W4306952671 cites W2029040796 @default.
- W4306952671 cites W2040316076 @default.
- W4306952671 cites W2046370810 @default.
- W4306952671 cites W2049810853 @default.
- W4306952671 cites W2056439160 @default.
- W4306952671 cites W2056631189 @default.
- W4306952671 cites W2058298068 @default.
- W4306952671 cites W2061316436 @default.
- W4306952671 cites W2062995866 @default.
- W4306952671 cites W2073038315 @default.
- W4306952671 cites W2081306620 @default.
- W4306952671 cites W2085709433 @default.
- W4306952671 cites W2086717421 @default.
- W4306952671 cites W2100008240 @default.
- W4306952671 cites W2109984296 @default.
- W4306952671 cites W2115352852 @default.
- W4306952671 cites W2120599736 @default.
- W4306952671 cites W2121159616 @default.
- W4306952671 cites W2127334464 @default.
- W4306952671 cites W2136646559 @default.
- W4306952671 cites W2140464850 @default.
- W4306952671 cites W2158899370 @default.
- W4306952671 cites W2178047135 @default.
- W4306952671 cites W2188220894 @default.
- W4306952671 cites W2273814915 @default.
- W4306952671 cites W2346930423 @default.
- W4306952671 cites W2410028122 @default.
- W4306952671 cites W2471786891 @default.
- W4306952671 cites W2570172057 @default.
- W4306952671 cites W2630237784 @default.
- W4306952671 cites W2776528430 @default.
- W4306952671 cites W2923738150 @default.
- W4306952671 cites W2940535063 @default.
- W4306952671 cites W2944768042 @default.
- W4306952671 cites W2946337557 @default.
- W4306952671 cites W3033438356 @default.
- W4306952671 cites W3039305626 @default.
- W4306952671 cites W3092811086 @default.
- W4306952671 cites W3096284144 @default.
- W4306952671 cites W3119960175 @default.
- W4306952671 cites W3209528298 @default.
- W4306952671 cites W4255513644 @default.
- W4306952671 cites W4300632745 @default.
- W4306952671 doi "https://doi.org/10.1007/s10928-022-09824-w" @default.
- W4306952671 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36266517" @default.
- W4306952671 hasPublicationYear "2022" @default.
- W4306952671 type Work @default.
- W4306952671 citedByCount "0" @default.
- W4306952671 crossrefType "journal-article" @default.
- W4306952671 hasAuthorship W4306952671A5030877212 @default.
- W4306952671 hasAuthorship W4306952671A5072351058 @default.
- W4306952671 hasAuthorship W4306952671A5073950498 @default.
- W4306952671 hasBestOaLocation W43069526711 @default.
- W4306952671 hasConcept C112705442 @default.
- W4306952671 hasConcept C120882062 @default.
- W4306952671 hasConcept C126322002 @default.
- W4306952671 hasConcept C142724271 @default.
- W4306952671 hasConcept C150489694 @default.
- W4306952671 hasConcept C185592680 @default.
- W4306952671 hasConcept C185867374 @default.
- W4306952671 hasConcept C203014093 @default.
- W4306952671 hasConcept C2776042228 @default.
- W4306952671 hasConcept C2777714996 @default.
- W4306952671 hasConcept C2779644171 @default.
- W4306952671 hasConcept C41625074 @default.
- W4306952671 hasConcept C534529494 @default.
- W4306952671 hasConcept C55493867 @default.
- W4306952671 hasConcept C60903277 @default.
- W4306952671 hasConcept C71924100 @default.
- W4306952671 hasConcept C98274493 @default.
- W4306952671 hasConceptScore W4306952671C112705442 @default.
- W4306952671 hasConceptScore W4306952671C120882062 @default.
- W4306952671 hasConceptScore W4306952671C126322002 @default.
- W4306952671 hasConceptScore W4306952671C142724271 @default.
- W4306952671 hasConceptScore W4306952671C150489694 @default.
- W4306952671 hasConceptScore W4306952671C185592680 @default.
- W4306952671 hasConceptScore W4306952671C185867374 @default.
- W4306952671 hasConceptScore W4306952671C203014093 @default.
- W4306952671 hasConceptScore W4306952671C2776042228 @default.