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- W4306958149 abstract "Primary graft dysfunction is a common postoperative complication, lacking consensus regarding diagnostic criteria. Olthoff criteria are the most used, based on blood parameters in the first 7 postoperative days. This lack of consensus and late diagnosis evidence the need of early parameters. This study proposes factor V (FV) as a marker in the first 3 postoperative days for primary graft dysfunction.Within a 500-patient database, 27 patients with graft loss in the first 90 days were chosen and compared with a group of 54 patients composed of the immediately preceding and following transplant to each case. Through receiver operating characteristic curves, FV and maximum glutamic pyruvic transaminase (GPT) predictive value on the first 3 postoperative days were assessed. The best threshold value was selected according to the Youden index.FV was significantly higher in the control group, with second postoperative day as the highest discriminative one (area under the curve = 0.893). In addition, a cutoff point of FV 37.50 exhibited a specificity of 92% and sensibility of 69% in predicting allograft failure in the first 3 months. GPT showed a lower validity with area under the curve = 0.77, and a GPT of 1539 presented a specificity of 82% and sensibility of 67%. Combining FV < 37.5 and GPT > 1539, a specificity of 98% and sensibility of 55% was reached.FV could postulate as an early marker of primary graft dysfunction because of its high specificity despite having a lower sensibility. With de association of FV and GPT the maximum specificity for predicting graft loss in the first 3 months was reached, becoming a promising parameter for further analysis." @default.
- W4306958149 created "2022-10-21" @default.
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- W4306958149 date "2022-11-01" @default.
- W4306958149 modified "2023-10-12" @default.
- W4306958149 title "Primary Graft Dysfunction: Factor V's Value for Its Early Diagnosis" @default.
- W4306958149 cites W2019431164 @default.
- W4306958149 cites W2888121124 @default.
- W4306958149 doi "https://doi.org/10.1016/j.transproceed.2022.09.017" @default.
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