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- W4306964351 endingPage "2203499" @default.
- W4306964351 startingPage "2203499" @default.
- W4306964351 abstract "Outbreaks of coronaviruses (CoVs), especially severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), have posed serious threats to humans and animals, which urgently calls for effective broad-spectrum antivirals. RNA-dependent RNA polymerase (RdRp) plays an essential role in viral RNA synthesis and is an ideal pan-coronaviral therapeutic target. Herein, based on cryo-electron microscopy and biochemical approaches, gossypol (GOS) is identified from 881 natural products to directly block SARS-CoV-2 RdRp, thus inhibiting SARS-CoV-2 replication in both cellular and mouse infection models. GOS also acts as a potent inhibitor against the SARS-CoV-2 variant of concern (VOC) and exerts same inhibitory effects toward mutated RdRps of VOCs as the RdRp of the original SARS-CoV-2. Moreover, that the RdRp inhibitor GOS has broad-spectrum anti-coronavirus activity against alphacoronaviruses (porcine epidemic diarrhea virus and swine acute diarrhea syndrome coronavirus), betacoronaviruses (SARS-CoV-2), gammacoronaviruses (avian infectious bronchitis virus), and deltacoronaviruses (porcine deltacoronavirus) is showed. The findings demonstrate that GOS may serve as a promising lead compound for combating the ongoing COVID-19 pandemic and other coronavirus outbreaks." @default.
- W4306964351 created "2022-10-21" @default.
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- W4306964351 date "2022-10-20" @default.
- W4306964351 modified "2023-10-14" @default.
- W4306964351 title "Gossypol Broadly Inhibits Coronaviruses by Targeting RNA‐Dependent RNA Polymerases" @default.
- W4306964351 cites W1964798833 @default.
- W4306964351 cites W1984259198 @default.
- W4306964351 cites W2030140637 @default.
- W4306964351 cites W2043165163 @default.
- W4306964351 cites W2045204989 @default.
- W4306964351 cites W2085323444 @default.
- W4306964351 cites W2113953529 @default.
- W4306964351 cites W2132629607 @default.
- W4306964351 cites W2134967712 @default.
- W4306964351 cites W2144081223 @default.
- W4306964351 cites W2158337490 @default.
- W4306964351 cites W2170017134 @default.
- W4306964351 cites W2175569396 @default.
- W4306964351 cites W2180229411 @default.
- W4306964351 cites W2267223087 @default.
- W4306964351 cites W2311203695 @default.
- W4306964351 cites W2319575922 @default.
- W4306964351 cites W2344596255 @default.
- W4306964351 cites W2417879206 @default.
- W4306964351 cites W2593511418 @default.
- W4306964351 cites W2593833301 @default.
- W4306964351 cites W2725497285 @default.
- W4306964351 cites W2754416383 @default.
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- W4306964351 cites W2793022939 @default.
- W4306964351 cites W2795202046 @default.
- W4306964351 cites W2803480909 @default.
- W4306964351 cites W2805121345 @default.
- W4306964351 cites W2899285523 @default.
- W4306964351 cites W2899714098 @default.
- W4306964351 cites W2914796231 @default.
- W4306964351 cites W2924519734 @default.
- W4306964351 cites W2953320394 @default.
- W4306964351 cites W2971470127 @default.
- W4306964351 cites W2993763427 @default.
- W4306964351 cites W3000413850 @default.
- W4306964351 cites W3005212621 @default.
- W4306964351 cites W3007643904 @default.
- W4306964351 cites W3009912996 @default.
- W4306964351 cites W3015608194 @default.
- W4306964351 cites W3016296419 @default.
- W4306964351 cites W3022734398 @default.
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- W4306964351 cites W3101115975 @default.
- W4306964351 cites W3108130218 @default.
- W4306964351 cites W3111601351 @default.
- W4306964351 cites W3123421077 @default.
- W4306964351 cites W3126546961 @default.
- W4306964351 cites W3127380759 @default.
- W4306964351 cites W3131619507 @default.
- W4306964351 cites W3133499696 @default.
- W4306964351 cites W3133536922 @default.
- W4306964351 cites W3137876609 @default.
- W4306964351 cites W3154873719 @default.
- W4306964351 cites W3155304938 @default.
- W4306964351 cites W3161128666 @default.
- W4306964351 cites W3170598451 @default.
- W4306964351 cites W3173596479 @default.
- W4306964351 cites W3176531204 @default.
- W4306964351 cites W3185327986 @default.
- W4306964351 cites W3203993419 @default.
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- W4306964351 cites W3214486415 @default.
- W4306964351 cites W3217543721 @default.
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- W4306964351 cites W4226049216 @default.
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- W4306964351 doi "https://doi.org/10.1002/advs.202203499" @default.
- W4306964351 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36266926" @default.
- W4306964351 hasPublicationYear "2022" @default.
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