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- W4306969272 abstract "Endothelial cells (EC) are the anatomical boundaries between the intravascular and extravascular space. Damage to ECs is catastrophic and induces endothelial cell dysfunction. The pathogenesis is multifactorial and involves dysregulation in the signaling pathways, membrane lipids ratio disturbance, cell-cell adhesion disturbance, unfolded protein response, lysosomal and mitochondrial stress, autophagy dysregulation, and oxidative stress. Autophagy is a lysosomal-dependent turnover of intracellular components. Autophagy was recognized early in the pathogenesis of endothelial dysfunction. Autophagy is a remarkable patho (physiological) process in the cell homeostasis regulation including EC. Regulation of autophagy rate is disease-dependent and impaired with aging. Up-regulation of autophagy induces endothelial cell regeneration/differentiation and improves the function of impaired ones. The paper scrutinizes the molecular mechanisms and triggers of EC dysregulation and current perspectives for future therapeutic strategies by autophagy targeting." @default.
- W4306969272 created "2022-10-22" @default.
- W4306969272 creator A5065878254 @default.
- W4306969272 date "2022-10-21" @default.
- W4306969272 modified "2023-10-06" @default.
- W4306969272 title "Endothelial cell autophagy in the context of disease development" @default.
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- W4306969272 doi "https://doi.org/10.5115/acb.22.098" @default.
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