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• W4306980360 abstract "Abstract Background The current COVID-19 pandemic and the previous SARS/MERS outbreaks of 2003 and 2012 have resulted in a series of major global public health crises. We argue that in the interest of developing effective and safe vaccines and drugs and to better understand coronaviruses and associated disease mechenisms it is necessary to integrate the large and exponentially growing body of heterogeneous coronavirus data. Ontologies play an important role in standard-based knowledge and data representation, integration, sharing, and analysis. Accordingly, we initiated the development of the community-based Coronavirus Infectious Disease Ontology (CIDO) in early 2020. Results As an Open Biomedical Ontology (OBO) library ontology, CIDO is open source and interoperable with other existing OBO ontologies. CIDO is aligned with the Basic Formal Ontology and Viral Infectious Disease Ontology. CIDO has imported terms from over 30 OBO ontologies. For example, CIDO imports all SARS-CoV-2 protein terms from the Protein Ontology, COVID-19-related phenotype terms from the Human Phenotype Ontology, and over 100 COVID-19 terms for vaccines (both authorized and in clinical trial) from the Vaccine Ontology. CIDO systematically represents variants of SARS-CoV-2 viruses and over 300 amino acid substitutions therein, along with over 300 diagnostic kits and methods. CIDO also describes hundreds of host-coronavirus protein-protein interactions (PPIs) and the drugs that target proteins in these PPIs. CIDO has been used to model COVID-19 related phenomena in areas such as epidemiology. The scope of CIDO was evaluated by visual analysis supported by a summarization network method. CIDO has been used in various applications such as term standardization, inference, natural language processing (NLP) and clinical data integration. We have applied the amino acid variant knowledge present in CIDO to analyze differences between SARS-CoV-2 Delta and Omicron variants. CIDO's integrative host-coronavirus PPIs and drug-target knowledge has also been used to support drug repurposing for COVID-19 treatment. Conclusion CIDO represents entities and relations in the domain of coronavirus diseases with a special focus on COVID-19. It supports shared knowledge representation, data and metadata standardization and integration, and has been used in a range of applications." @default.
• W4306980360 created "2022-10-22" @default.
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• W4306980360 date "2022-10-21" @default.
• W4306980360 modified "2023-10-17" @default.
• W4306980360 title "A comprehensive update on CIDO: the community-based coronavirus infectious disease ontology" @default.
• W4306980360 cites W1541250240 @default.
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• W4306980360 cites W1998028266 @default.
• W4306980360 cites W2021074129 @default.
• W4306980360 cites W2052250375 @default.
• W4306980360 cites W2057705283 @default.
• W4306980360 cites W2062558911 @default.
• W4306980360 cites W2085752173 @default.
• W4306980360 cites W2103260426 @default.
• W4306980360 cites W2108621502 @default.
• W4306980360 cites W2120535580 @default.
• W4306980360 cites W2130420078 @default.
• W4306980360 cites W2142635855 @default.
• W4306980360 cites W2159583324 @default.
• W4306980360 cites W2171304642 @default.
• W4306980360 cites W2261812172 @default.
• W4306980360 cites W2302501749 @default.
• W4306980360 cites W2470579970 @default.
• W4306980360 cites W2565909019 @default.
• W4306980360 cites W2597000813 @default.
• W4306980360 cites W2605343262 @default.
• W4306980360 cites W2767757128 @default.
• W4306980360 cites W2767891136 @default.
• W4306980360 cites W2783839275 @default.
• W4306980360 cites W2917858269 @default.
• W4306980360 cites W2945602507 @default.
• W4306980360 cites W2962969117 @default.
• W4306980360 cites W2974429973 @default.
• W4306980360 cites W3001652609 @default.
• W4306980360 cites W3008090185 @default.
• W4306980360 cites W3011420630 @default.
• W4306980360 cites W3012652877 @default.
• W4306980360 cites W3014281460 @default.
• W4306980360 cites W3018965582 @default.
• W4306980360 cites W3022285953 @default.
• W4306980360 cites W3025586072 @default.
• W4306980360 cites W3027630905 @default.
• W4306980360 cites W3035434194 @default.
• W4306980360 cites W3036377341 @default.
• W4306980360 cites W3040508291 @default.
• W4306980360 cites W3043124965 @default.
• W4306980360 cites W3044670453 @default.
• W4306980360 cites W3048573059 @default.
• W4306980360 cites W3049452588 @default.
• W4306980360 cites W3087585143 @default.
• W4306980360 cites W3092226560 @default.
• W4306980360 cites W3105753785 @default.
• W4306980360 cites W3106811464 @default.
• W4306980360 cites W3107112434 @default.
• W4306980360 cites W3108374836 @default.
• W4306980360 cites W3110289085 @default.

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