FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4306989164> ?p ?o ?g. }

• W4306989164 abstract "Ring-finger protein 5 (RNF5) is an E3 ubiquitin ligase which is expressed in a variety of human tissues. RNF5 is involved in the regulation of endoplasmic reticulum stress, inflammation, and innate immunity and plays an important role in the occurrence and development of various tumors. However, the role of RNF5 in cardiac hypertrophy has not been reported. In this study, we found the expression of RNF5 was increased in the hearts of mice with pathological cardiac hypertrophy. The loss-of-function research demonstrated that RNF5 deficiency exacerbated cardiac hypertrophy, whereas gain-of-function studies revealed that overexpression of RNF5 had opposite effects. The stimulator of interferon genes (STING) is a signaling molecule that can activate type I interferon immunity, which can meditate inflammation and immune response in many diseases. The protein-protein interaction experiments confirmed that STING interacted with RNF5. Further studies showed that RNF5 inhibited cardiac hypertrophy by promoting STING degradation through K48-linked polyubiquitination. Therefore, we defined RNF5 as importantly regulated signaling for cardiac hypertrophy." @default.
• W4306989164 created "2022-10-22" @default.
• W4306989164 creator A5001014826 @default.
• W4306989164 creator A5006291503 @default.
• W4306989164 creator A5008504817 @default.
• W4306989164 creator A5013539347 @default.
• W4306989164 creator A5027236266 @default.
• W4306989164 creator A5040120577 @default.
• W4306989164 creator A5052031810 @default.
• W4306989164 creator A5052267876 @default.
• W4306989164 creator A5055081013 @default.
• W4306989164 creator A5064246076 @default.
• W4306989164 creator A5083988864 @default.
• W4306989164 date "2022-10-21" @default.
• W4306989164 modified "2023-10-14" @default.
• W4306989164 title "E3 ubiquitin ligase RNF5 attenuates pathological cardiac hypertrophy through STING" @default.
• W4306989164 cites W1550057873 @default.
• W4306989164 cites W1596313018 @default.
• W4306989164 cites W1775199813 @default.
• W4306989164 cites W1968367248 @default.
• W4306989164 cites W1999042302 @default.
• W4306989164 cites W2007754282 @default.
• W4306989164 cites W2008559063 @default.
• W4306989164 cites W2019474212 @default.
• W4306989164 cites W2022376508 @default.
• W4306989164 cites W2039601697 @default.
• W4306989164 cites W2044330780 @default.
• W4306989164 cites W2077813547 @default.
• W4306989164 cites W2078174631 @default.
• W4306989164 cites W2136851415 @default.
• W4306989164 cites W2164926713 @default.
• W4306989164 cites W2165019570 @default.
• W4306989164 cites W2415715899 @default.
• W4306989164 cites W2728290384 @default.
• W4306989164 cites W2769070740 @default.
• W4306989164 cites W2799410199 @default.
• W4306989164 cites W2883803263 @default.
• W4306989164 cites W2954294089 @default.
• W4306989164 cites W2990651874 @default.
• W4306989164 cites W3007774890 @default.
• W4306989164 cites W3122226502 @default.
• W4306989164 cites W3125293813 @default.
• W4306989164 cites W3179827971 @default.
• W4306989164 cites W4232767515 @default.
• W4306989164 doi "https://doi.org/10.1038/s41419-022-05231-8" @default.
• W4306989164 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36270989" @default.
• W4306989164 hasPublicationYear "2022" @default.
• W4306989164 type Work @default.
• W4306989164 citedByCount "3" @default.
• W4306989164 countsByYear W43069891642023 @default.
• W4306989164 crossrefType "journal-article" @default.
• W4306989164 hasAuthorship W4306989164A5001014826 @default.
• W4306989164 hasAuthorship W4306989164A5006291503 @default.
• W4306989164 hasAuthorship W4306989164A5008504817 @default.
• W4306989164 hasAuthorship W4306989164A5013539347 @default.
• W4306989164 hasAuthorship W4306989164A5027236266 @default.
• W4306989164 hasAuthorship W4306989164A5040120577 @default.
• W4306989164 hasAuthorship W4306989164A5052031810 @default.
• W4306989164 hasAuthorship W4306989164A5052267876 @default.
• W4306989164 hasAuthorship W4306989164A5055081013 @default.
• W4306989164 hasAuthorship W4306989164A5064246076 @default.
• W4306989164 hasAuthorship W4306989164A5083988864 @default.
• W4306989164 hasBestOaLocation W43069891641 @default.
• W4306989164 hasConcept C104317684 @default.
• W4306989164 hasConcept C111566952 @default.
• W4306989164 hasConcept C126322002 @default.
• W4306989164 hasConcept C127413603 @default.
• W4306989164 hasConcept C134018914 @default.
• W4306989164 hasConcept C134459356 @default.
• W4306989164 hasConcept C136449434 @default.
• W4306989164 hasConcept C146978453 @default.
• W4306989164 hasConcept C158617107 @default.
• W4306989164 hasConcept C167414201 @default.
• W4306989164 hasConcept C203014093 @default.
• W4306989164 hasConcept C25602115 @default.
• W4306989164 hasConcept C2776178377 @default.
• W4306989164 hasConcept C2776914184 @default.
• W4306989164 hasConcept C2777349159 @default.
• W4306989164 hasConcept C2778198053 @default.
• W4306989164 hasConcept C2779300339 @default.
• W4306989164 hasConcept C2780559512 @default.
• W4306989164 hasConcept C55493867 @default.
• W4306989164 hasConcept C71924100 @default.
• W4306989164 hasConcept C86803240 @default.
• W4306989164 hasConcept C8891405 @default.
• W4306989164 hasConcept C95444343 @default.
• W4306989164 hasConceptScore W4306989164C104317684 @default.
• W4306989164 hasConceptScore W4306989164C111566952 @default.
• W4306989164 hasConceptScore W4306989164C126322002 @default.
• W4306989164 hasConceptScore W4306989164C127413603 @default.
• W4306989164 hasConceptScore W4306989164C134018914 @default.
• W4306989164 hasConceptScore W4306989164C134459356 @default.
• W4306989164 hasConceptScore W4306989164C136449434 @default.
• W4306989164 hasConceptScore W4306989164C146978453 @default.
• W4306989164 hasConceptScore W4306989164C158617107 @default.
• W4306989164 hasConceptScore W4306989164C167414201 @default.
• W4306989164 hasConceptScore W4306989164C203014093 @default.
• W4306989164 hasConceptScore W4306989164C25602115 @default.
• W4306989164 hasConceptScore W4306989164C2776178377 @default.
• W4306989164 hasConceptScore W4306989164C2776914184 @default.

• next