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- W4306989466 abstract "Overview Primary liver cancer is the second leading cause of cancer death in men and the sixth leading cause among women worldwide. Its incidence in the United States has more than tripled since 1980. Hepatocellular carcinoma (HCC) constitutes three‐fourths of primary hepatic neoplasms, followed by intrahepatic cholangiocarcinoma (ICC) (10–15%) and other less common hepatic malignancies (5%) such as hepatic angiosarcoma, epithelioid hemangioendothelioma, or hepatic lymphoma. Primary hepatic malignancies are generally associated with poor survival, and limited systemic therapy options are available. As such, prevention, screening (in the case of HCC), early diagnosis, and multidisciplinary management are key to maximizing outcomes. In addition, most primary hepatic neoplasms are associated with chronic liver disease or cirrhosis, such that the resultant decreased hepatic functional reserve often precludes aggressive treatment for tumors. Therefore, for treatment selection, one should consider two intrinsic conflicting factors: curability and safety of treatment. Currently, several clinical staging systems and treatment algorithms are available to adequately select therapeutic options for HCC. The choice of therapy is individualized based on the tumor burden, degree of underlying liver disease, patient performance status, and the overall possibility of side effects or complications, and must be balanced with the anticipated benefits. Selection of treatment should be determined in a multidisciplinary fashion with the available local expertise. For patients with HCC or ICC, treatment options with curative intent including surgical resection, ablation, and orthotopic liver transplantation (OLT) should be the first priority as long as these treatments are approved." @default.
- W4306989466 created "2022-10-22" @default.
- W4306989466 creator A5021139165 @default.
- W4306989466 creator A5082695058 @default.
- W4306989466 creator A5090593363 @default.
- W4306989466 date "2022-10-21" @default.
- W4306989466 modified "2023-09-26" @default.
- W4306989466 title "Primary Neoplasms of the Liver" @default.
- W4306989466 cites W1500226632 @default.
- W4306989466 cites W1500343633 @default.
- W4306989466 cites W1510049477 @default.
- W4306989466 cites W1522687886 @default.
- W4306989466 cites W1551301313 @default.
- W4306989466 cites W1595010482 @default.
- W4306989466 cites W1607593178 @default.
- W4306989466 cites W1679583167 @default.
- W4306989466 cites W1828082159 @default.
- W4306989466 cites W1895232916 @default.
- W4306989466 cites W1934479321 @default.
- W4306989466 cites W1963570372 @default.
- W4306989466 cites W1964829819 @default.
- W4306989466 cites W1971058470 @default.
- W4306989466 cites W1971837077 @default.
- W4306989466 cites W1973679060 @default.
- W4306989466 cites W1974128990 @default.
- W4306989466 cites W1976820549 @default.
- W4306989466 cites W1981000343 @default.
- W4306989466 cites W1981811517 @default.
- W4306989466 cites W1982467949 @default.
- W4306989466 cites W1984061101 @default.
- W4306989466 cites W1984873869 @default.
- W4306989466 cites W1986523663 @default.
- W4306989466 cites W1988051941 @default.
- W4306989466 cites W1990980861 @default.
- W4306989466 cites W1992149176 @default.
- W4306989466 cites W1993359365 @default.
- W4306989466 cites W1994193851 @default.
- W4306989466 cites W1996781488 @default.
- W4306989466 cites W1996952383 @default.
- W4306989466 cites W1998078404 @default.
- W4306989466 cites W1999426782 @default.
- W4306989466 cites W2000249913 @default.
- W4306989466 cites W2000741017 @default.
- W4306989466 cites W2000931643 @default.
- W4306989466 cites W2001886660 @default.
- W4306989466 cites W2002605005 @default.
- W4306989466 cites W2002998858 @default.
- W4306989466 cites W2004016630 @default.
- W4306989466 cites W2004017296 @default.
- W4306989466 cites W2005502331 @default.
- W4306989466 cites W2006781865 @default.
- W4306989466 cites W2008173493 @default.
- W4306989466 cites W2008896731 @default.
- W4306989466 cites W2010885438 @default.
- W4306989466 cites W2012707575 @default.
- W4306989466 cites W2017741306 @default.
- W4306989466 cites W2017742221 @default.
- W4306989466 cites W2018976763 @default.
- W4306989466 cites W2021299297 @default.
- W4306989466 cites W2021625611 @default.
- W4306989466 cites W2022073038 @default.
- W4306989466 cites W2025890159 @default.
- W4306989466 cites W2027380378 @default.
- W4306989466 cites W2027604117 @default.
- W4306989466 cites W2028228473 @default.
- W4306989466 cites W2029318640 @default.
- W4306989466 cites W2031335401 @default.
- W4306989466 cites W2033547704 @default.
- W4306989466 cites W2034888244 @default.
- W4306989466 cites W2035794058 @default.
- W4306989466 cites W2036304264 @default.
- W4306989466 cites W2036394799 @default.
- W4306989466 cites W2037680028 @default.
- W4306989466 cites W2040358727 @default.
- W4306989466 cites W2040406598 @default.
- W4306989466 cites W2040510760 @default.
- W4306989466 cites W2042209473 @default.
- W4306989466 cites W2047314052 @default.
- W4306989466 cites W2047542072 @default.
- W4306989466 cites W2048920089 @default.
- W4306989466 cites W2052765084 @default.
- W4306989466 cites W2053435298 @default.
- W4306989466 cites W2056827569 @default.
- W4306989466 cites W2057752123 @default.
- W4306989466 cites W2057977939 @default.
- W4306989466 cites W2059201072 @default.
- W4306989466 cites W2060052458 @default.
- W4306989466 cites W2060948030 @default.
- W4306989466 cites W2062708830 @default.
- W4306989466 cites W2063005653 @default.
- W4306989466 cites W2064113906 @default.
- W4306989466 cites W2065412511 @default.
- W4306989466 cites W2066242337 @default.
- W4306989466 cites W2067376737 @default.
- W4306989466 cites W2067787763 @default.
- W4306989466 cites W2068652437 @default.
- W4306989466 cites W2070080743 @default.
- W4306989466 cites W2072554662 @default.