FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4306999363> ?p ?o ?g. }

• W4306999363 endingPage "95" @default.
• W4306999363 startingPage "89" @default.
• W4306999363 abstract "Nicotinamide adenine dinucleotide (NAD+), a biological molecule integral to redox reactions involved in multiple cellular processes, has the potential to treat nonalcoholic fatty liver diseases (NAFLDs) and nonalcoholic steatohepatitis (NASH). Nicotinamide mononucleotide adenylyltransferase (Nmnat1), one of the NAD+ biosynthesizing enzymes, plays a central role in all NAD+ metabolic pathways and it is vital to embryonic development. However, the function of Nmnat1 in metabolic pathology and, specifically, in the development and progression of NAFLD and NASH remains unexplored. First, we generated hepatic Nmnat1 knockout (H-Nmnat1−/−) mice to investigate the physiological function of Nmnat1 and found that NAD+ levels were significantly lower in H-Nmnat1−/− mice than control mice. However, H-Nmnat1−/− mice appeared normal with comparable metabolic activity. Next, we used three different diet-induced NASH models to assess the pathophysiological role of Nmant1 in metabolic disorders and discovered that hepatic loos of Nmnat1 decreased 35%–40% of total NAD+ in an obese state. Nevertheless, our analysis of phenotypic variations found comparable body composition, gene expression, and liver histology in all NASH models in H-Nmnat1−/− mice. We also found that aged H-Nmnat1−/− mice exhibited comparable liver phenotypes with control mice. These findings suggest that Nmnat1 has a redundancy to the pathophysiology of obesity-induced hepatic disorders." @default.
• W4306999363 created "2022-10-22" @default.
• W4306999363 creator A5007877509 @default.
• W4306999363 creator A5007921825 @default.
• W4306999363 creator A5040323246 @default.
• W4306999363 creator A5043342162 @default.
• W4306999363 creator A5076462928 @default.
• W4306999363 creator A5081906664 @default.
• W4306999363 creator A5085800941 @default.
• W4306999363 date "2022-12-01" @default.
• W4306999363 modified "2023-09-30" @default.
• W4306999363 title "Loss of hepatic Nmnat1 has no impact on diet-induced fatty liver disease" @default.
• W4306999363 cites W1553665319 @default.
• W4306999363 cites W1959721425 @default.
• W4306999363 cites W1963683487 @default.
• W4306999363 cites W2002349285 @default.
• W4306999363 cites W2004585208 @default.
• W4306999363 cites W2005526533 @default.
• W4306999363 cites W2007462819 @default.
• W4306999363 cites W2009010832 @default.
• W4306999363 cites W2018904083 @default.
• W4306999363 cites W2035682260 @default.
• W4306999363 cites W2038011036 @default.
• W4306999363 cites W2045442669 @default.
• W4306999363 cites W2048878532 @default.
• W4306999363 cites W2050412495 @default.
• W4306999363 cites W2050612118 @default.
• W4306999363 cites W2056564149 @default.
• W4306999363 cites W2066326400 @default.
• W4306999363 cites W2068054518 @default.
• W4306999363 cites W2068128334 @default.
• W4306999363 cites W2073988218 @default.
• W4306999363 cites W2082393205 @default.
• W4306999363 cites W2087439645 @default.
• W4306999363 cites W2087656397 @default.
• W4306999363 cites W2089674086 @default.
• W4306999363 cites W2090895117 @default.
• W4306999363 cites W2116511131 @default.
• W4306999363 cites W2118613904 @default.
• W4306999363 cites W2151853260 @default.
• W4306999363 cites W2204688218 @default.
• W4306999363 cites W2236926495 @default.
• W4306999363 cites W2328891011 @default.
• W4306999363 cites W2347073712 @default.
• W4306999363 cites W2400466055 @default.
• W4306999363 cites W2411199679 @default.
• W4306999363 cites W2531683815 @default.
• W4306999363 cites W2580009538 @default.
• W4306999363 cites W2806961305 @default.
• W4306999363 cites W2944227504 @default.
• W4306999363 cites W2963446625 @default.
• W4306999363 cites W2967538127 @default.
• W4306999363 cites W2970055787 @default.
• W4306999363 cites W2973205401 @default.
• W4306999363 cites W3006500690 @default.
• W4306999363 cites W3021238814 @default.
• W4306999363 cites W3134320092 @default.
• W4306999363 cites W3186416146 @default.
• W4306999363 cites W3211521906 @default.
• W4306999363 doi "https://doi.org/10.1016/j.bbrc.2022.10.072" @default.
• W4306999363 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36332487" @default.
• W4306999363 hasPublicationYear "2022" @default.
• W4306999363 type Work @default.
• W4306999363 citedByCount "2" @default.
• W4306999363 countsByYear W43069993632023 @default.
• W4306999363 crossrefType "journal-article" @default.
• W4306999363 hasAuthorship W4306999363A5007877509 @default.
• W4306999363 hasAuthorship W4306999363A5007921825 @default.
• W4306999363 hasAuthorship W4306999363A5040323246 @default.
• W4306999363 hasAuthorship W4306999363A5043342162 @default.
• W4306999363 hasAuthorship W4306999363A5076462928 @default.
• W4306999363 hasAuthorship W4306999363A5081906664 @default.
• W4306999363 hasAuthorship W4306999363A5085800941 @default.
• W4306999363 hasConcept C10162356 @default.
• W4306999363 hasConcept C104317684 @default.
• W4306999363 hasConcept C126322002 @default.
• W4306999363 hasConcept C134018914 @default.
• W4306999363 hasConcept C181199279 @default.
• W4306999363 hasConcept C182704531 @default.
• W4306999363 hasConcept C185592680 @default.
• W4306999363 hasConcept C2776901170 @default.
• W4306999363 hasConcept C2777088662 @default.
• W4306999363 hasConcept C55493867 @default.
• W4306999363 hasConcept C71924100 @default.
• W4306999363 hasConcept C75520062 @default.
• W4306999363 hasConcept C86803240 @default.
• W4306999363 hasConceptScore W4306999363C10162356 @default.
• W4306999363 hasConceptScore W4306999363C104317684 @default.
• W4306999363 hasConceptScore W4306999363C126322002 @default.
• W4306999363 hasConceptScore W4306999363C134018914 @default.
• W4306999363 hasConceptScore W4306999363C181199279 @default.
• W4306999363 hasConceptScore W4306999363C182704531 @default.
• W4306999363 hasConceptScore W4306999363C185592680 @default.
• W4306999363 hasConceptScore W4306999363C2776901170 @default.
• W4306999363 hasConceptScore W4306999363C2777088662 @default.
• W4306999363 hasConceptScore W4306999363C55493867 @default.
• W4306999363 hasConceptScore W4306999363C71924100 @default.
• W4306999363 hasConceptScore W4306999363C75520062 @default.

• next