Matches in SemOpenAlex for { <https://semopenalex.org/work/W4307029485> ?p ?o ?g. }
- W4307029485 abstract "Testis ischaemia-reperfusion (I/R) plays a vital role in male infertility. Recent studies have demonstrated that paracrine factors of mesenchymal stem cells exert the transplanted cells' reparative effects. The present experimental study aimed to investigate the effects of conditioned medium (CM) of bone marrow-derived mesenchymal stem cells (BMMSCs). In this study, 21 rats were separated into three groups of 7 animals: sham, I/R and I/R plus CM. Sperm parameters were measured at the end of this study. Moreover, histological parameters were examined. 2-Deoxyuridine 5-triphosphate nick-end labelling (TUNEL) assay was done to assess the apoptotic cells. The count of adhered neutrophils was measured in subtunical venules. Testicular I/R led to a significant reduction in the viability and concentration of sperm and resulted in a significant elevation in the rate of abnormal sperms in comparison with sham. The CM-treated group demonstrated a significant reduction in the rate of abnormal sperm and a significant elevation in the viability and concentration of sperm compared with the I/R group. Based on the morphometric analysis, in the I/R group, epithelial thickness and seminiferous tubule diameter significantly decreased in comparison with sham. A significant reduction was seen between the I/R and sham groups regarding the mean testicular biopsy score (MTBS) value. However, an improvement was observed in the I/R + CM group MTBS value in comparison with the I/R group. TUNEL assay showed that the apoptotic cells in the seminiferous tubules belonging to the I/R group were significantly higher compared with the control. Nevertheless, apoptotic cells were reduced in the I/R + CM group compared with the I/R group. Results of the present study showed that CM of BMMSCs exerts protective effects on the testicular I/R damages." @default.
- W4307029485 created "2022-10-22" @default.
- W4307029485 creator A5006919497 @default.
- W4307029485 creator A5049774308 @default.
- W4307029485 creator A5058685458 @default.
- W4307029485 creator A5059588485 @default.
- W4307029485 date "2022-10-21" @default.
- W4307029485 modified "2023-09-29" @default.
- W4307029485 title "Conditioned medium of bone marrow mesenchymal stem cells improves sperm parameters and reduces histological alteration in rat testicular ischaemia/reperfusion model" @default.
- W4307029485 cites W1566480800 @default.
- W4307029485 cites W1967451638 @default.
- W4307029485 cites W1968073601 @default.
- W4307029485 cites W1968395524 @default.
- W4307029485 cites W1976295478 @default.
- W4307029485 cites W1986295151 @default.
- W4307029485 cites W1987352783 @default.
- W4307029485 cites W1990961954 @default.
- W4307029485 cites W1996978950 @default.
- W4307029485 cites W1997984658 @default.
- W4307029485 cites W2016759352 @default.
- W4307029485 cites W2058122659 @default.
- W4307029485 cites W2075453095 @default.
- W4307029485 cites W2087094669 @default.
- W4307029485 cites W2091552026 @default.
- W4307029485 cites W2098849525 @default.
- W4307029485 cites W2102830683 @default.
- W4307029485 cites W2112918495 @default.
- W4307029485 cites W2123163588 @default.
- W4307029485 cites W2129609671 @default.
- W4307029485 cites W2170878087 @default.
- W4307029485 cites W2344761101 @default.
- W4307029485 cites W2397726802 @default.
- W4307029485 cites W2623131062 @default.
- W4307029485 cites W2801124752 @default.
- W4307029485 cites W2901396145 @default.
- W4307029485 cites W2923737915 @default.
- W4307029485 cites W2943269896 @default.
- W4307029485 cites W2943755588 @default.
- W4307029485 cites W2963179667 @default.
- W4307029485 cites W2973738434 @default.
- W4307029485 cites W2986966326 @default.
- W4307029485 cites W3010964964 @default.
- W4307029485 cites W3042430718 @default.
- W4307029485 cites W3082571069 @default.
- W4307029485 cites W3091713160 @default.
- W4307029485 cites W3093080582 @default.
- W4307029485 cites W3093300087 @default.
- W4307029485 cites W3128111292 @default.
- W4307029485 cites W3132767930 @default.
- W4307029485 cites W3145217248 @default.
- W4307029485 cites W3167944072 @default.
- W4307029485 cites W3173411060 @default.
- W4307029485 cites W773515714 @default.
- W4307029485 doi "https://doi.org/10.1111/and.14624" @default.
- W4307029485 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36270637" @default.
- W4307029485 hasPublicationYear "2022" @default.
- W4307029485 type Work @default.
- W4307029485 citedByCount "3" @default.
- W4307029485 countsByYear W43070294852023 @default.
- W4307029485 crossrefType "journal-article" @default.
- W4307029485 hasAuthorship W4307029485A5006919497 @default.
- W4307029485 hasAuthorship W4307029485A5049774308 @default.
- W4307029485 hasAuthorship W4307029485A5058685458 @default.
- W4307029485 hasAuthorship W4307029485A5059588485 @default.
- W4307029485 hasBestOaLocation W43070294851 @default.
- W4307029485 hasConcept C123765429 @default.
- W4307029485 hasConcept C126322002 @default.
- W4307029485 hasConcept C142724271 @default.
- W4307029485 hasConcept C16685009 @default.
- W4307029485 hasConcept C170493617 @default.
- W4307029485 hasConcept C190283241 @default.
- W4307029485 hasConcept C196795494 @default.
- W4307029485 hasConcept C198826908 @default.
- W4307029485 hasConcept C2777338322 @default.
- W4307029485 hasConcept C2777688143 @default.
- W4307029485 hasConcept C2778054371 @default.
- W4307029485 hasConcept C2779234561 @default.
- W4307029485 hasConcept C2781068068 @default.
- W4307029485 hasConcept C2781087480 @default.
- W4307029485 hasConcept C54355233 @default.
- W4307029485 hasConcept C55493867 @default.
- W4307029485 hasConcept C71924100 @default.
- W4307029485 hasConcept C7876069 @default.
- W4307029485 hasConcept C86803240 @default.
- W4307029485 hasConceptScore W4307029485C123765429 @default.
- W4307029485 hasConceptScore W4307029485C126322002 @default.
- W4307029485 hasConceptScore W4307029485C142724271 @default.
- W4307029485 hasConceptScore W4307029485C16685009 @default.
- W4307029485 hasConceptScore W4307029485C170493617 @default.
- W4307029485 hasConceptScore W4307029485C190283241 @default.
- W4307029485 hasConceptScore W4307029485C196795494 @default.
- W4307029485 hasConceptScore W4307029485C198826908 @default.
- W4307029485 hasConceptScore W4307029485C2777338322 @default.
- W4307029485 hasConceptScore W4307029485C2777688143 @default.
- W4307029485 hasConceptScore W4307029485C2778054371 @default.
- W4307029485 hasConceptScore W4307029485C2779234561 @default.
- W4307029485 hasConceptScore W4307029485C2781068068 @default.
- W4307029485 hasConceptScore W4307029485C2781087480 @default.
- W4307029485 hasConceptScore W4307029485C54355233 @default.
- W4307029485 hasConceptScore W4307029485C55493867 @default.