FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4307031966> ?p ?o ?g. }

• W4307031966 endingPage "1150" @default.
• W4307031966 startingPage "1139" @default.
• W4307031966 abstract "ABSTRACT Background Inflammation is a key driver of the transition of acute kidney injury to progressive fibrosis and chronic kidney disease (AKI-to-CKD transition). Blocking a-disintegrin-and-metalloprotease-17 (ADAM17)-dependent ectodomain shedding, in particular of epidermal growth factor receptor (EGFR) ligands and of the type 1 inflammatory cytokine tumor necrosis factor (TNF), reduces pro-inflammatory and pro-fibrotic responses after ischemic AKI or unilateral ureteral obstruction (UUO), a classical fibrosis model. Metalloprotease or EGFR inhibition show significant undesirable side effects in humans. In retrospective studies anti-TNF biologics reduce the incidence and progression of CKD in humans. Whether TNF has a role in AKI-to-CKD transition and how TNF inhibition compares to EGFR inhibition is largely unknown. Methods Mice were subjected to bilateral renal ischemia-reperfusion injury or unilateral ureteral obstruction. Kidneys were analyzed by histology, immunohistochemistry, qPCR, western blot, mass cytometry, scRNA sequencing, and cytokine profiling. Results Here we show that TNF or EGFR inhibition reduce AKI-to-CKD transition and fibrosis equally by about 25%, while combination has no additional effect. EGFR inhibition reduced kidney TNF expression by about 50% largely by reducing accumulation of TNF expressing immune cells in the kidney early after AKI, while TNF inhibition did not affect EGFR activation or immune cell accumulation. Using scRNAseq data we show that TNF is predominantly expressed by immune cells in AKI but not in proximal tubule cells (PTC), and PTC-TNF knockout did not affect AKI-to-CKD transition in UUO. Thus, the anti-inflammatory and anti-fibrotic effects of the anti-TNF biologic etanercept in AKI-to-CKD transition rely on blocking TNF that is released from immune cells recruited or accumulating in response to PTC-EGFR signals. Conclusion Short-term anti-TNF biologics during or after AKI could be helpful in the prevention of AKI-to-CKD transition." @default.
• W4307031966 created "2022-10-23" @default.
• W4307031966 creator A5007376714 @default.
• W4307031966 creator A5043763969 @default.
• W4307031966 creator A5044174128 @default.
• W4307031966 creator A5049287628 @default.
• W4307031966 creator A5053596904 @default.
• W4307031966 creator A5066358338 @default.
• W4307031966 date "2022-10-21" @default.
• W4307031966 modified "2023-10-11" @default.
• W4307031966 title "TNF or EGFR inhibition equally block AKI-to-CKD transition: opportunities for etanercept treatment" @default.
• W4307031966 cites W1600560134 @default.
• W4307031966 cites W1965616728 @default.
• W4307031966 cites W1970919452 @default.
• W4307031966 cites W1974654284 @default.
• W4307031966 cites W1976987666 @default.
• W4307031966 cites W1989945871 @default.
• W4307031966 cites W1993447091 @default.
• W4307031966 cites W1993931106 @default.
• W4307031966 cites W1998812648 @default.
• W4307031966 cites W1999755139 @default.
• W4307031966 cites W2012209877 @default.
• W4307031966 cites W2018267029 @default.
• W4307031966 cites W2028368506 @default.
• W4307031966 cites W2029774820 @default.
• W4307031966 cites W2072271841 @default.
• W4307031966 cites W2079079821 @default.
• W4307031966 cites W2083595902 @default.
• W4307031966 cites W2085854349 @default.
• W4307031966 cites W2098218848 @default.
• W4307031966 cites W2099540110 @default.
• W4307031966 cites W2110899107 @default.
• W4307031966 cites W2115034481 @default.
• W4307031966 cites W2122914905 @default.
• W4307031966 cites W2125346357 @default.
• W4307031966 cites W2132782966 @default.
• W4307031966 cites W2140612433 @default.
• W4307031966 cites W2142136897 @default.
• W4307031966 cites W2147155927 @default.
• W4307031966 cites W2148001954 @default.
• W4307031966 cites W2151053450 @default.
• W4307031966 cites W2156935689 @default.
• W4307031966 cites W2160966717 @default.
• W4307031966 cites W2167781127 @default.
• W4307031966 cites W2169981609 @default.
• W4307031966 cites W2216845378 @default.
• W4307031966 cites W2306327748 @default.
• W4307031966 cites W2389390523 @default.
• W4307031966 cites W2510993238 @default.
• W4307031966 cites W2565319519 @default.
• W4307031966 cites W2624744472 @default.
• W4307031966 cites W2787384683 @default.
• W4307031966 cites W2800399031 @default.
• W4307031966 cites W2928665623 @default.
• W4307031966 cites W2947512282 @default.
• W4307031966 cites W2949177718 @default.
• W4307031966 cites W2953064750 @default.
• W4307031966 cites W2966502448 @default.
• W4307031966 cites W2968128868 @default.
• W4307031966 cites W2984472267 @default.
• W4307031966 cites W2988935279 @default.
• W4307031966 cites W3036487861 @default.
• W4307031966 cites W3043498163 @default.
• W4307031966 cites W3094473528 @default.
• W4307031966 cites W3159571651 @default.
• W4307031966 cites W3174265886 @default.
• W4307031966 cites W3188459170 @default.
• W4307031966 cites W4213032184 @default.
• W4307031966 cites W4214539912 @default.
• W4307031966 cites W4282982919 @default.
• W4307031966 doi "https://doi.org/10.1093/ndt/gfac290" @default.
• W4307031966 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36269313" @default.
• W4307031966 hasPublicationYear "2022" @default.
• W4307031966 type Work @default.
• W4307031966 citedByCount "5" @default.
• W4307031966 countsByYear W43070319662023 @default.
• W4307031966 crossrefType "journal-article" @default.
• W4307031966 hasAuthorship W4307031966A5007376714 @default.
• W4307031966 hasAuthorship W4307031966A5043763969 @default.
• W4307031966 hasAuthorship W4307031966A5044174128 @default.
• W4307031966 hasAuthorship W4307031966A5049287628 @default.
• W4307031966 hasAuthorship W4307031966A5053596904 @default.
• W4307031966 hasAuthorship W4307031966A5066358338 @default.
• W4307031966 hasConcept C121608353 @default.
• W4307031966 hasConcept C126322002 @default.
• W4307031966 hasConcept C142724271 @default.
• W4307031966 hasConcept C170493617 @default.
• W4307031966 hasConcept C17991360 @default.
• W4307031966 hasConcept C2777226972 @default.
• W4307031966 hasConcept C2778653478 @default.
• W4307031966 hasConcept C2778690821 @default.
• W4307031966 hasConcept C2779013556 @default.
• W4307031966 hasConcept C2779438470 @default.
• W4307031966 hasConcept C2780091579 @default.
• W4307031966 hasConcept C2780472472 @default.
• W4307031966 hasConcept C2780559512 @default.
• W4307031966 hasConcept C502942594 @default.
• W4307031966 hasConcept C71924100 @default.

• next