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- W4307036151 abstract "Abstract Subtelomeres are dynamic genomic regions shaped by elevated rates of recombination, mutation, and gene birth/death. These processes contribute to formation of lineage-specific gene family expansions that commonly occupy subtelomeres across eukaryotes. Investigating the evolution of subtelomeric gene families is complicated by the presence of repetitive DNA and high sequence similarity among gene family members that prevents accurate assembly from whole genome sequences. Here, we investigated the evolution of the telomere-associated (TLO) gene family in Candida albicans using 189 complete coding sequences retrieved from 23 genetically diverse strains across the species. Tlo genes conformed to the 3 major architectural groups (α/β/γ) previously defined in the genome reference strain but significantly differed in the degree of within-group diversity. One group, Tloβ, was always found at the same chromosome arm with strong sequence similarity among all strains. In contrast, diverse Tloα sequences have proliferated among chromosome arms. Tloγ genes formed 7 primary clades that included each of the previously identified Tloγ genes from the genome reference strain with 3 Tloγ genes always found on the same chromosome arm among strains. Architectural groups displayed regions of high conservation that resolved newly identified functional motifs, providing insight into potential regulatory mechanisms that distinguish groups. Thus, by resolving intraspecies subtelomeric gene variation, it is possible to identify previously unknown gene family complexity that may underpin adaptive functional variation." @default.
- W4307036151 created "2022-10-23" @default.
- W4307036151 creator A5004441101 @default.
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- W4307036151 creator A5053724622 @default.
- W4307036151 creator A5070808008 @default.
- W4307036151 date "2022-10-21" @default.
- W4307036151 modified "2023-09-27" @default.
- W4307036151 title "Architectural groups of a subtelomeric gene family evolve along distinct paths in <i>Candida albicans</i>" @default.
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- W4307036151 doi "https://doi.org/10.1093/g3journal/jkac283" @default.
- W4307036151 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36269198" @default.
- W4307036151 hasPublicationYear "2022" @default.
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