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- W4307038225 abstract "The ubiquitin-proteasome system is vital to hormone-mediated developmental and stress responses in plants. Ubiquitin ligases target hormone-specific transcriptional activators (TAs) for degradation, but how TAs are processed by proteasomes remains unknown. We report that in Arabidopsis, the salicylic acid- and ethylene-responsive TAs, NPR1 and EIN3, are relayed from pathway-specific ubiquitin ligases to proteasome-associated HECT-type UPL3/4 ligases. Activity and stability of NPR1 were regulated by sequential action of three ubiquitin ligases, including UPL3/4, while proteasome processing of EIN3 required physical handover between ethylene-responsive SCFEBF2 and UPL3/4 ligases. Consequently, UPL3/4 controlled extensive hormone-induced developmental and stress-responsive transcriptional programs. Thus, our findings identify unknown ubiquitin ligase relays that terminate with proteasome-associated HECT-type ligases, which may be a universal mechanism for processive degradation of proteasome-targeted TAs and other substrates." @default.
- W4307038225 created "2022-10-23" @default.
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- W4307038225 date "2022-10-21" @default.
- W4307038225 modified "2023-10-03" @default.
- W4307038225 title "Proteasome-associated ubiquitin ligase relays target plant hormone-specific transcriptional activators" @default.
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- W4307038225 doi "https://doi.org/10.1126/sciadv.abn4466" @default.
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