Matches in SemOpenAlex for { <https://semopenalex.org/work/W4307045996> ?p ?o ?g. }
- W4307045996 endingPage "111807" @default.
- W4307045996 startingPage "111807" @default.
- W4307045996 abstract "Preovulatory granulosa cell (GC) differentiation is essential for the maturation and release of oocytes from the ovary. We have previously demonstrated that follicle-stimulating hormone (FSH) and insulin-like growth factors (IGFs) closely interact to control GC function. Similarly, we showed that GATA4 mediates FSH actions and it is required for preovulatory follicle formation. This report aimed to determine in vivo the effect of FSH on GATA4 phosphorylation and to investigate whether FSH and IGF1 interact to regulate GATA4 activity. In rat ovaries, treatment with equine chorionic gonadotropin (eCG) increased the phosphorylation of GATA4, which was confined to the nucleus of GCs. Using primary rat GCs, we observed that GATA4 phosphorylation at serine 105 increases the transcriptional activity of this transcription factor. Like FSH, IGF1 stimulated GATA4 phosphorylation at serine 105. Interestingly, GATA4 phosphorylation was significantly higher in cells cotreated with FSH and IGF1 when compared to FSH or IGF1 alone, suggesting that IGF1 augments the effects of FSH on GATA4. It was also found that the enhancing effect of IGF1 requires AKT activity and is mimicked by the inhibition of glycogen synthase kinase-3 β (GSK3β), suggesting that AKT inhibition of GSK3β may play a role in the regulation of GATA4 phosphorylation. The data support an important role of the IGF1/AKT/GSK3β signaling pathway in the regulation of GATA4 transcriptional activity and provide new insights into the mechanisms by which FSH and IGF1 regulate GC differentiation. Our findings suggest that GATA4 transcriptional activation may, at least partially, mediate AKT actions in GCs." @default.
- W4307045996 created "2022-10-23" @default.
- W4307045996 creator A5008672669 @default.
- W4307045996 creator A5050837674 @default.
- W4307045996 creator A5055257842 @default.
- W4307045996 date "2023-01-01" @default.
- W4307045996 modified "2023-09-26" @default.
- W4307045996 title "Insulin-like growth factor 1 enhances follicle-stimulating hormone-induced phosphorylation of GATA4 in rat granulosa cells" @default.
- W4307045996 cites W1592353043 @default.
- W4307045996 cites W1821524341 @default.
- W4307045996 cites W1966916621 @default.
- W4307045996 cites W1967550038 @default.
- W4307045996 cites W1968119300 @default.
- W4307045996 cites W1975301513 @default.
- W4307045996 cites W1976167156 @default.
- W4307045996 cites W1979134116 @default.
- W4307045996 cites W1982417024 @default.
- W4307045996 cites W1987348391 @default.
- W4307045996 cites W1990829953 @default.
- W4307045996 cites W1999030960 @default.
- W4307045996 cites W2002982022 @default.
- W4307045996 cites W2005821186 @default.
- W4307045996 cites W2012356167 @default.
- W4307045996 cites W2013877353 @default.
- W4307045996 cites W2015615030 @default.
- W4307045996 cites W2016128965 @default.
- W4307045996 cites W2019104313 @default.
- W4307045996 cites W2021612259 @default.
- W4307045996 cites W2031091378 @default.
- W4307045996 cites W2035362985 @default.
- W4307045996 cites W2048327621 @default.
- W4307045996 cites W2058954639 @default.
- W4307045996 cites W2061904534 @default.
- W4307045996 cites W2063816440 @default.
- W4307045996 cites W2077213568 @default.
- W4307045996 cites W2082807027 @default.
- W4307045996 cites W2083574570 @default.
- W4307045996 cites W2093752260 @default.
- W4307045996 cites W2121745326 @default.
- W4307045996 cites W2123617510 @default.
- W4307045996 cites W2128048967 @default.
- W4307045996 cites W2132044686 @default.
- W4307045996 cites W2132136466 @default.
- W4307045996 cites W2138158343 @default.
- W4307045996 cites W2146736665 @default.
- W4307045996 cites W2154688073 @default.
- W4307045996 cites W2159134726 @default.
- W4307045996 cites W2161421542 @default.
- W4307045996 cites W2169237598 @default.
- W4307045996 cites W2171795919 @default.
- W4307045996 cites W2211903500 @default.
- W4307045996 cites W2605895898 @default.
- W4307045996 cites W2979525565 @default.
- W4307045996 cites W3173796257 @default.
- W4307045996 doi "https://doi.org/10.1016/j.mce.2022.111807" @default.
- W4307045996 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36279967" @default.
- W4307045996 hasPublicationYear "2023" @default.
- W4307045996 type Work @default.
- W4307045996 citedByCount "0" @default.
- W4307045996 crossrefType "journal-article" @default.
- W4307045996 hasAuthorship W4307045996A5008672669 @default.
- W4307045996 hasAuthorship W4307045996A5050837674 @default.
- W4307045996 hasAuthorship W4307045996A5055257842 @default.
- W4307045996 hasBestOaLocation W43070459962 @default.
- W4307045996 hasConcept C104317684 @default.
- W4307045996 hasConcept C116186050 @default.
- W4307045996 hasConcept C11960822 @default.
- W4307045996 hasConcept C126322002 @default.
- W4307045996 hasConcept C134018914 @default.
- W4307045996 hasConcept C170493617 @default.
- W4307045996 hasConcept C182996813 @default.
- W4307045996 hasConcept C185592680 @default.
- W4307045996 hasConcept C192118531 @default.
- W4307045996 hasConcept C2775960820 @default.
- W4307045996 hasConcept C2777702977 @default.
- W4307045996 hasConcept C2778575703 @default.
- W4307045996 hasConcept C2779279165 @default.
- W4307045996 hasConcept C2781289246 @default.
- W4307045996 hasConcept C55493867 @default.
- W4307045996 hasConcept C62478195 @default.
- W4307045996 hasConcept C71315377 @default.
- W4307045996 hasConcept C71924100 @default.
- W4307045996 hasConcept C75217442 @default.
- W4307045996 hasConcept C86339819 @default.
- W4307045996 hasConcept C86803240 @default.
- W4307045996 hasConcept C95444343 @default.
- W4307045996 hasConceptScore W4307045996C104317684 @default.
- W4307045996 hasConceptScore W4307045996C116186050 @default.
- W4307045996 hasConceptScore W4307045996C11960822 @default.
- W4307045996 hasConceptScore W4307045996C126322002 @default.
- W4307045996 hasConceptScore W4307045996C134018914 @default.
- W4307045996 hasConceptScore W4307045996C170493617 @default.
- W4307045996 hasConceptScore W4307045996C182996813 @default.
- W4307045996 hasConceptScore W4307045996C185592680 @default.
- W4307045996 hasConceptScore W4307045996C192118531 @default.
- W4307045996 hasConceptScore W4307045996C2775960820 @default.
- W4307045996 hasConceptScore W4307045996C2777702977 @default.
- W4307045996 hasConceptScore W4307045996C2778575703 @default.