FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4307058623> ?p ?o ?g. }

• W4307058623 endingPage "113902" @default.
• W4307058623 startingPage "113902" @default.
• W4307058623 abstract "Obesity, a growing health problem in the world, is related to a series of mental disorders, including anxiety and depression. XiaoYao San (XYS), a prescription of traditional Chinese medicine (TCM), has been widely used in the clinical treatment of anxiety and depression in China. However, the efficacy of XYS on obesity-related neuropsychiatric dysfunction and the underlying neural mechanisms remain unclear. Here, using a high-fat diet (HFD)-induced obese model, we found that XYS treatment significantly improves obesity-related anxiety- and depression-like behaviors and alters the gut microbiome, particularly by increasing the relative abundance of Faecalibaculum rodentium (F. rodentium), in mice. Interestingly, selective supplementation with F. rodentium or its metabolic products, short-chain fatty acids (SCFAs), is sufficient to rescue anxiety- and depression-like behaviors in HFD-fed mice. Next, we determined that the transcriptional level of dopamine D2 receptor (DRD2), which activation usually inhibits inflammation in the central nervous system (CNS), is significantly increased in the medial prefrontal cortex (mPFC) of XYS-treated mice when compared with that of vehicle-treated controls. Moreover, enriched pathways analysis with the differential expression genes (DEGs) showed that some of these DEGs are enriched in neuroinflammatory pathways. We further noticed that treatment with XYS contributes to controlling microglial activation and proinflammatory responses in the mPFC and hippocampus of HFD-fed mice. Overall, this study reveals that XYS rescues HFD-induced anxiety and depression via modulating gut microbiota-derived metabolites and that XYS is a potential therapeutic strategy for treating obesity-associated mental disorders." @default.
• W4307058623 created "2022-10-23" @default.
• W4307058623 creator A5012005569 @default.
• W4307058623 creator A5020554965 @default.
• W4307058623 creator A5039590366 @default.
• W4307058623 creator A5051247143 @default.
• W4307058623 date "2022-12-01" @default.
• W4307058623 modified "2023-10-17" @default.
• W4307058623 title "Xiaoyao San ameliorates high-fat diet-induced anxiety and depression via regulating gut microbiota in mice" @default.
• W4307058623 cites W1515023627 @default.
• W4307058623 cites W1927710737 @default.
• W4307058623 cites W1981500982 @default.
• W4307058623 cites W1994665290 @default.
• W4307058623 cites W2002703043 @default.
• W4307058623 cites W2007580094 @default.
• W4307058623 cites W2009939083 @default.
• W4307058623 cites W2019946207 @default.
• W4307058623 cites W2035382111 @default.
• W4307058623 cites W2046345187 @default.
• W4307058623 cites W2053464248 @default.
• W4307058623 cites W2067267561 @default.
• W4307058623 cites W2087084954 @default.
• W4307058623 cites W2100391099 @default.
• W4307058623 cites W2122459017 @default.
• W4307058623 cites W2133371501 @default.
• W4307058623 cites W2134526812 @default.
• W4307058623 cites W2140937256 @default.
• W4307058623 cites W2146037555 @default.
• W4307058623 cites W2147439481 @default.
• W4307058623 cites W2158218002 @default.
• W4307058623 cites W2179438025 @default.
• W4307058623 cites W2205259970 @default.
• W4307058623 cites W2336534940 @default.
• W4307058623 cites W2415197886 @default.
• W4307058623 cites W2548933161 @default.
• W4307058623 cites W2567447937 @default.
• W4307058623 cites W2575018533 @default.
• W4307058623 cites W2583164539 @default.
• W4307058623 cites W2590130858 @default.
• W4307058623 cites W2666299810 @default.
• W4307058623 cites W2746558379 @default.
• W4307058623 cites W2773602539 @default.
• W4307058623 cites W2785023044 @default.
• W4307058623 cites W2792802831 @default.
• W4307058623 cites W2800009248 @default.
• W4307058623 cites W2804137773 @default.
• W4307058623 cites W2807828439 @default.
• W4307058623 cites W2891851874 @default.
• W4307058623 cites W2900569176 @default.
• W4307058623 cites W2903881924 @default.
• W4307058623 cites W2908142980 @default.
• W4307058623 cites W2912754252 @default.
• W4307058623 cites W2929404193 @default.
• W4307058623 cites W2942596738 @default.
• W4307058623 cites W2946372752 @default.
• W4307058623 cites W2949600376 @default.
• W4307058623 cites W2963083369 @default.
• W4307058623 cites W2987794425 @default.
• W4307058623 cites W2989655487 @default.
• W4307058623 cites W2998380179 @default.
• W4307058623 cites W3001680293 @default.
• W4307058623 cites W3003912482 @default.
• W4307058623 cites W3007431409 @default.
• W4307058623 cites W3094330590 @default.
• W4307058623 cites W3137997840 @default.
• W4307058623 cites W3155320732 @default.
• W4307058623 cites W3179184768 @default.
• W4307058623 cites W3179327521 @default.
• W4307058623 cites W3184990332 @default.
• W4307058623 doi "https://doi.org/10.1016/j.biopha.2022.113902" @default.
• W4307058623 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36279723" @default.
• W4307058623 hasPublicationYear "2022" @default.
• W4307058623 type Work @default.
• W4307058623 citedByCount "6" @default.
• W4307058623 countsByYear W43070586232023 @default.
• W4307058623 crossrefType "journal-article" @default.
• W4307058623 hasAuthorship W4307058623A5012005569 @default.
• W4307058623 hasAuthorship W4307058623A5020554965 @default.
• W4307058623 hasAuthorship W4307058623A5039590366 @default.
• W4307058623 hasAuthorship W4307058623A5051247143 @default.
• W4307058623 hasBestOaLocation W43070586231 @default.
• W4307058623 hasConcept C118552586 @default.
• W4307058623 hasConcept C126322002 @default.
• W4307058623 hasConcept C134018914 @default.
• W4307058623 hasConcept C164027704 @default.
• W4307058623 hasConcept C169900460 @default.
• W4307058623 hasConcept C173586616 @default.
• W4307058623 hasConcept C203014093 @default.
• W4307058623 hasConcept C2776914184 @default.
• W4307058623 hasConcept C2781161787 @default.
• W4307058623 hasConcept C2781195155 @default.
• W4307058623 hasConcept C539455810 @default.
• W4307058623 hasConcept C558461103 @default.
• W4307058623 hasConcept C71924100 @default.
• W4307058623 hasConceptScore W4307058623C118552586 @default.
• W4307058623 hasConceptScore W4307058623C126322002 @default.
• W4307058623 hasConceptScore W4307058623C134018914 @default.
• W4307058623 hasConceptScore W4307058623C164027704 @default.

• next