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- W4307126417 endingPage "1121" @default.
- W4307126417 startingPage "1081" @default.
- W4307126417 abstract "Abstract Pyrimidine itself or in different fused forms is an important chemical motif for every step of cell life. Alongside, it exists as a key pharmacophoric part in thiamine, alloxan, orotic acid, and other isoforms of nucleotide bases. It has emerged as a privileged scaffold in medicinal chemistry due to its various possible structural and pharmacological attributes. In a number of clinically used chemical agents, pyrimidine or its fused/clubbed form with other moieties act as a key pharmacophore. Structure activity relationship (SAR) studies of the explored derivatives demonstrated that slight modifications with various substitutions on the pyrimidine rings can deviate biological activity to a large extent. 2‐Pyrimidone and 2,4‐pyrimidione derivatives are largely explored by a number of research groups for various pharmacological targets and due to their similarity to nucleotide bases, it has a great impact on the biological profile of these molecules. The current review focuses on describing the recent advancements (2015 onward) in the development of pyrimidine‐based biologically active molecules along with drug candidates under different clinical trials. The aim of this review is to provide structural features associated with pyrimidine along with their SAR studies, which are believed to be valuable for the scientists working on the development of pyrimidine‐based small molecules in the aforementioned disease conditions. We believe that the results of this research will help to provide a structural idea that may be used in the design and development of new pyrimidine‐based small molecules that target a variety of receptors or enzymes." @default.
- W4307126417 created "2022-10-27" @default.
- W4307126417 creator A5002343801 @default.
- W4307126417 creator A5007382391 @default.
- W4307126417 creator A5017400258 @default.
- W4307126417 creator A5030817137 @default.
- W4307126417 creator A5068295341 @default.
- W4307126417 creator A5079152763 @default.
- W4307126417 creator A5086658025 @default.
- W4307126417 date "2022-11-01" @default.
- W4307126417 modified "2023-10-16" @default.
- W4307126417 title "An insight on medicinal attributes of pyrimidine scaffold: An updated review" @default.
- W4307126417 cites W1507116499 @default.
- W4307126417 cites W153750880 @default.
- W4307126417 cites W1972182556 @default.
- W4307126417 cites W1978481580 @default.
- W4307126417 cites W1984328540 @default.
- W4307126417 cites W1986648865 @default.
- W4307126417 cites W2005803584 @default.
- W4307126417 cites W2011037019 @default.
- W4307126417 cites W2013891472 @default.
- W4307126417 cites W2022276674 @default.
- W4307126417 cites W2024058260 @default.
- W4307126417 cites W2033271256 @default.
- W4307126417 cites W2035490834 @default.
- W4307126417 cites W2047156711 @default.
- W4307126417 cites W2054245301 @default.
- W4307126417 cites W2055568666 @default.
- W4307126417 cites W2071343186 @default.
- W4307126417 cites W2090276137 @default.
- W4307126417 cites W2092413204 @default.
- W4307126417 cites W2093534165 @default.
- W4307126417 cites W2096584200 @default.
- W4307126417 cites W2100074717 @default.
- W4307126417 cites W2100183382 @default.
- W4307126417 cites W2113428683 @default.
- W4307126417 cites W2113636405 @default.
- W4307126417 cites W2151103936 @default.
- W4307126417 cites W2164193797 @default.
- W4307126417 cites W2208491189 @default.
- W4307126417 cites W2213440267 @default.
- W4307126417 cites W2327856369 @default.
- W4307126417 cites W2337077673 @default.
- W4307126417 cites W2355646343 @default.
- W4307126417 cites W2398669046 @default.
- W4307126417 cites W2404223049 @default.
- W4307126417 cites W2494248072 @default.
- W4307126417 cites W2507283455 @default.
- W4307126417 cites W2507307020 @default.
- W4307126417 cites W2518286871 @default.
- W4307126417 cites W2524047578 @default.
- W4307126417 cites W2529330909 @default.
- W4307126417 cites W2588865688 @default.
- W4307126417 cites W2594902788 @default.
- W4307126417 cites W2597049796 @default.
- W4307126417 cites W2618794576 @default.
- W4307126417 cites W2646084010 @default.
- W4307126417 cites W2733347532 @default.
- W4307126417 cites W2735858118 @default.
- W4307126417 cites W2736194893 @default.
- W4307126417 cites W2739324967 @default.
- W4307126417 cites W2741194912 @default.
- W4307126417 cites W2746676262 @default.
- W4307126417 cites W2747235866 @default.
- W4307126417 cites W2772851773 @default.
- W4307126417 cites W2782078804 @default.
- W4307126417 cites W2783355479 @default.
- W4307126417 cites W2789898832 @default.
- W4307126417 cites W2789959403 @default.
- W4307126417 cites W2791434193 @default.
- W4307126417 cites W2792017095 @default.
- W4307126417 cites W2792268181 @default.
- W4307126417 cites W2792578312 @default.
- W4307126417 cites W2795374938 @default.
- W4307126417 cites W2802338619 @default.
- W4307126417 cites W2807110388 @default.
- W4307126417 cites W2807668403 @default.
- W4307126417 cites W2809631507 @default.
- W4307126417 cites W2891147283 @default.
- W4307126417 cites W2900188698 @default.
- W4307126417 cites W2902642593 @default.
- W4307126417 cites W2913992324 @default.
- W4307126417 cites W2942626681 @default.
- W4307126417 cites W2943503365 @default.
- W4307126417 cites W2945154057 @default.
- W4307126417 cites W2948371288 @default.
- W4307126417 cites W2952780907 @default.
- W4307126417 cites W2960808001 @default.
- W4307126417 cites W2964449445 @default.
- W4307126417 cites W2982297806 @default.
- W4307126417 cites W2988816049 @default.
- W4307126417 cites W2992112979 @default.
- W4307126417 cites W3017454836 @default.
- W4307126417 cites W3025044551 @default.
- W4307126417 cites W3034963872 @default.
- W4307126417 cites W3085080249 @default.
- W4307126417 cites W3087708642 @default.
- W4307126417 cites W3090934236 @default.