Matches in SemOpenAlex for { <https://semopenalex.org/work/W4307144268> ?p ?o ?g. }
Showing items 1 to 66 of
66
with 100 items per page.
- W4307144268 endingPage "e306" @default.
- W4307144268 startingPage "e306" @default.
- W4307144268 abstract "<h3>Purpose/Objective(s)</h3> Reliable predictors are urgently needed to identify stage II nasopharyngeal carcinoma (NPC) patients who could benefit from concurrent chemoradiotherapy (CCRT). We determined the value of comprehensive nodal features for predicting survival and CCRT benefit for stage II NPC patients. <h3>Materials/Methods</h3> In all, 242 patients diagnosed with stage II NPC from 2007 to 2017 receiving CCRT (N=84) or intensity-modulated radiotherapy alone (IMRT, N=158) were enrolled. Relationships between diverse nodal features and survival outcomes were investigated. Significant predictors of overall survival (OS) in multivariable analysis were scored according to hazard ratio values. Based on total scores of each patient, a risk calculator–nodal feature-based prognostic model was derived to predict OS and CCRT benefit. The Kaplan–Meier method was applied to estimate survival outcomes. C-indexes were used to compare predictive efficiency between the risk model and TNM stage. <h3>Results</h3> Age ≥50 years (HR=2.93; P=0.01), ≥4 nodes (HR=2.80; P=0.03) and level III node involvement (HR=3.81; P=0.01) were independent prognostic factors for worse OS. The C-indexes of the risk model and TNM stage for predicting OS were 0.76 and 0.53, respectively. Intermediate-risk patients receiving CCRT had better 5-year OS than those receiving IMRT (89.5%, 77.8%; P=0.02). No benefit was found for low-/high-risk patients. <h3>Conclusion</h3> The number of metastatic nodes and level III node involvement are critical for predicting OS and CCRT benefit for stage II NPC patients. The prognostic model based on these variables could be used to optimize treatment intensity, suggesting that CCRT may be the optimal strategy for intermediate-risk populations; high-risk patients may require more intensive treatment, while IMRT alone is adequate for low-risk patients." @default.
- W4307144268 created "2022-10-28" @default.
- W4307144268 creator A5050294563 @default.
- W4307144268 creator A5073568097 @default.
- W4307144268 creator A5078081067 @default.
- W4307144268 creator A5081505742 @default.
- W4307144268 creator A5086581552 @default.
- W4307144268 date "2022-11-01" @default.
- W4307144268 modified "2023-09-28" @default.
- W4307144268 title "MRI-Identified Multidimensional Nodal Features: Predict Survival and Concurrent Chemotherapy Benefit for Stage II Nasopharyngeal Carcinoma" @default.
- W4307144268 doi "https://doi.org/10.1016/j.ijrobp.2022.07.1356" @default.
- W4307144268 hasPublicationYear "2022" @default.
- W4307144268 type Work @default.
- W4307144268 citedByCount "0" @default.
- W4307144268 crossrefType "journal-article" @default.
- W4307144268 hasAuthorship W4307144268A5050294563 @default.
- W4307144268 hasAuthorship W4307144268A5073568097 @default.
- W4307144268 hasAuthorship W4307144268A5078081067 @default.
- W4307144268 hasAuthorship W4307144268A5081505742 @default.
- W4307144268 hasAuthorship W4307144268A5086581552 @default.
- W4307144268 hasConcept C126322002 @default.
- W4307144268 hasConcept C143998085 @default.
- W4307144268 hasConcept C146357865 @default.
- W4307144268 hasConcept C151730666 @default.
- W4307144268 hasConcept C207103383 @default.
- W4307144268 hasConcept C2778424827 @default.
- W4307144268 hasConcept C2778997737 @default.
- W4307144268 hasConcept C44249647 @default.
- W4307144268 hasConcept C50382708 @default.
- W4307144268 hasConcept C509974204 @default.
- W4307144268 hasConcept C71924100 @default.
- W4307144268 hasConcept C83330619 @default.
- W4307144268 hasConcept C86803240 @default.
- W4307144268 hasConceptScore W4307144268C126322002 @default.
- W4307144268 hasConceptScore W4307144268C143998085 @default.
- W4307144268 hasConceptScore W4307144268C146357865 @default.
- W4307144268 hasConceptScore W4307144268C151730666 @default.
- W4307144268 hasConceptScore W4307144268C207103383 @default.
- W4307144268 hasConceptScore W4307144268C2778424827 @default.
- W4307144268 hasConceptScore W4307144268C2778997737 @default.
- W4307144268 hasConceptScore W4307144268C44249647 @default.
- W4307144268 hasConceptScore W4307144268C50382708 @default.
- W4307144268 hasConceptScore W4307144268C509974204 @default.
- W4307144268 hasConceptScore W4307144268C71924100 @default.
- W4307144268 hasConceptScore W4307144268C83330619 @default.
- W4307144268 hasConceptScore W4307144268C86803240 @default.
- W4307144268 hasIssue "3" @default.
- W4307144268 hasLocation W43071442681 @default.
- W4307144268 hasOpenAccess W4307144268 @default.
- W4307144268 hasPrimaryLocation W43071442681 @default.
- W4307144268 hasRelatedWork W2087536441 @default.
- W4307144268 hasRelatedWork W2359861678 @default.
- W4307144268 hasRelatedWork W2370261434 @default.
- W4307144268 hasRelatedWork W2389159739 @default.
- W4307144268 hasRelatedWork W2765301856 @default.
- W4307144268 hasRelatedWork W2908440491 @default.
- W4307144268 hasRelatedWork W3031731364 @default.
- W4307144268 hasRelatedWork W3091964053 @default.
- W4307144268 hasRelatedWork W3127553691 @default.
- W4307144268 hasRelatedWork W4307144268 @default.
- W4307144268 hasVolume "114" @default.
- W4307144268 isParatext "false" @default.
- W4307144268 isRetracted "false" @default.
- W4307144268 workType "article" @default.