FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4307145385> ?p ?o ?g. }

• W4307145385 endingPage "e516" @default.
• W4307145385 startingPage "e516" @default.
• W4307145385 abstract "<h3>Purpose/Objective(s)</h3> Radiation-induced heart disease (RIHD) may occur after excessive radiotherapy to thoracic cancer. However, the effect of cardiac irradiation on left ventricle (LV) function is still controversial and no previous studies has evaluated the importance of stroke volume (SV) in RIHD. The hypothesis is that diastolic dysfunction with decreased SV could be potentially effective echocardiography parameters to identify RIHD in the mouse model. <h3>Materials/Methods</h3> C57 mice (n=5-10 per group) were treated with a single heart X-ray radiation for 20Gy or 0Gy. Echocardiography was performed to evaluate changes in LV dimensions and function before radiation and after radiation 4, 8 weeks. Elisa kits were used to detect the level of serum BNP and cTnI. HE, Masson's trichrome and Sirius red staining was utilized to assess cardiomyocytes size and myocardial fibrosis. Data are expressed as mean values (means±SEM). Statistical analyses were performed using the two-way repeated measures ANOVA or one-way ANOVA for multiple comparisons and student's t-test for unpaired two groups. In all statistical analyses, significance was defined as P < 0.05. <h3>Results</h3> The Myocardial histopathology indicated a markably increased cardiac fibrosis area and cardiomyocytes size at 8 weeks after radiation. Echocardiography analyses revealed that SV (27.02±1.131 vs. 41.64±2.021ul, P<0.0001), the LV end-diastolic volume (45.64±5.054 vs. 72.24±3.758ul, P=0.0018), and cardiac output (12.58±0.6669 vs. 19.16±0.9942ml/min, P<0.0002) of the 20Gy-mice have significantly decreased than the 0Gy-mice at 8 weeks. The dead 20Gy-mice had lower SV (22.40±0.6110 vs. 30.48±0.1827ul, P=0.0153) as compared to the survival 20Gy-mice. Moreover, the LV diastolic anterior (1.042±0.05123 vs. 0.8456±0.02860mm, P=0.0398) and posterior (0.8745±0.02558 vs. 0.7701±0.02551mm, P=0.0290) wall thickness of 20Gy-mice also had significantly increased than the 0Gy-mice. However, there were no significant difference of the EF (P>0.05), fraction shortening (P>0.05), heart rate (P>0.05), and LV end-systolic volume (P>0.05) between two groups at all the time points. In addition, the result of Elisa kits showed that serum BNP level (427.3±34.05 vs. 279.8±24.84ng/ml, P=0.0127) of 20Gy-mice was significantly higher than the 0Gy-mice at 8 weeks while cTnI was not significantly changed. <h3>Conclusion</h3> Diastolic dysfunction and decreased SV instead of systolic dysfunction occurs firstly in radiation-induced heart disease, which could be effective indexes to detect cardiac toxicity induced by irradiation." @default.
• W4307145385 created "2022-10-28" @default.
• W4307145385 creator A5005501131 @default.
• W4307145385 creator A5016172497 @default.
• W4307145385 creator A5032416741 @default.
• W4307145385 creator A5046158921 @default.
• W4307145385 creator A5059774562 @default.
• W4307145385 creator A5069881082 @default.
• W4307145385 creator A5070835682 @default.
• W4307145385 date "2022-11-01" @default.
• W4307145385 modified "2023-09-24" @default.
• W4307145385 title "Effective Echocardiography Parameters to Identify Radiation-Induced Heart Disease in the Mouse Model" @default.
• W4307145385 doi "https://doi.org/10.1016/j.ijrobp.2022.07.2098" @default.
• W4307145385 hasPublicationYear "2022" @default.
• W4307145385 type Work @default.
• W4307145385 citedByCount "0" @default.
• W4307145385 crossrefType "journal-article" @default.
• W4307145385 hasAuthorship W4307145385A5005501131 @default.
• W4307145385 hasAuthorship W4307145385A5016172497 @default.
• W4307145385 hasAuthorship W4307145385A5032416741 @default.
• W4307145385 hasAuthorship W4307145385A5046158921 @default.
• W4307145385 hasAuthorship W4307145385A5059774562 @default.
• W4307145385 hasAuthorship W4307145385A5069881082 @default.
• W4307145385 hasAuthorship W4307145385A5070835682 @default.
• W4307145385 hasConcept C111566952 @default.
• W4307145385 hasConcept C126322002 @default.
• W4307145385 hasConcept C142724271 @default.
• W4307145385 hasConcept C163031210 @default.
• W4307145385 hasConcept C164705383 @default.
• W4307145385 hasConcept C2778198053 @default.
• W4307145385 hasConcept C2778921608 @default.
• W4307145385 hasConcept C2779770810 @default.
• W4307145385 hasConcept C2780074459 @default.
• W4307145385 hasConcept C2780559512 @default.
• W4307145385 hasConcept C3018763269 @default.
• W4307145385 hasConcept C544855455 @default.
• W4307145385 hasConcept C57900726 @default.
• W4307145385 hasConcept C71924100 @default.
• W4307145385 hasConcept C84393581 @default.
• W4307145385 hasConcept C99476002 @default.
• W4307145385 hasConceptScore W4307145385C111566952 @default.
• W4307145385 hasConceptScore W4307145385C126322002 @default.
• W4307145385 hasConceptScore W4307145385C142724271 @default.
• W4307145385 hasConceptScore W4307145385C163031210 @default.
• W4307145385 hasConceptScore W4307145385C164705383 @default.
• W4307145385 hasConceptScore W4307145385C2778198053 @default.
• W4307145385 hasConceptScore W4307145385C2778921608 @default.
• W4307145385 hasConceptScore W4307145385C2779770810 @default.
• W4307145385 hasConceptScore W4307145385C2780074459 @default.
• W4307145385 hasConceptScore W4307145385C2780559512 @default.
• W4307145385 hasConceptScore W4307145385C3018763269 @default.
• W4307145385 hasConceptScore W4307145385C544855455 @default.
• W4307145385 hasConceptScore W4307145385C57900726 @default.
• W4307145385 hasConceptScore W4307145385C71924100 @default.
• W4307145385 hasConceptScore W4307145385C84393581 @default.
• W4307145385 hasConceptScore W4307145385C99476002 @default.
• W4307145385 hasIssue "3" @default.
• W4307145385 hasLocation W43071453851 @default.
• W4307145385 hasOpenAccess W4307145385 @default.
• W4307145385 hasPrimaryLocation W43071453851 @default.
• W4307145385 hasRelatedWork W2100281649 @default.
• W4307145385 hasRelatedWork W2136377350 @default.
• W4307145385 hasRelatedWork W2804907242 @default.
• W4307145385 hasRelatedWork W2899831642 @default.
• W4307145385 hasRelatedWork W3121430770 @default.
• W4307145385 hasRelatedWork W3157830730 @default.
• W4307145385 hasRelatedWork W3165810863 @default.
• W4307145385 hasRelatedWork W4221003133 @default.
• W4307145385 hasRelatedWork W4307145385 @default.
• W4307145385 hasRelatedWork W76034163 @default.
• W4307145385 hasVolume "114" @default.
• W4307145385 isParatext "false" @default.
• W4307145385 isRetracted "false" @default.
• W4307145385 workType "article" @default.