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- W4307155457 endingPage "103219" @default.
- W4307155457 startingPage "103219" @default.
- W4307155457 abstract "Eosinophilic granulomatosis with polyangiitis (EGPA) is a rare, multi-system, inflammatory disease, belonging to the group of anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitides (AAV). Previously known as Churg-Strauss syndrome, EGPA is characterised by late-onset asthma, eosinophilia and vasculitis affecting small-to-medium vessels. This disease behaves differently in many aspects to the other AAV and is often excluded from AAV studies. The disease is poorly understood and, due to it rarity and unique manifestations, there has been limited research progress to optimise our understanding of its complex pathogenesis and ability to develop management options – although the success of interleukin-5 inhibitors such as Mepolizumab has been a welcome development. The pathophysiology also appears to be different to other forms of AAV and hence management strategies that work for AAV may not fully apply to this condition. There is no current standard therapy for EGPA although corticosteroids are almost universally used for treatment alongside other agents and encouraging modes of treatment continue to evolve beyond glucocorticoid immunosuppression (including interleukin-5 inhibition). There is therefore a significant ongoing unmet need for efficacious steroid-sparing immunosuppressing agents. The prognosis also diverges from other forms of AAV, and we discuss the pathophysiology, clinical features and diagnosis, management and prognosis in this article." @default.
- W4307155457 created "2022-10-28" @default.
- W4307155457 creator A5020404180 @default.
- W4307155457 creator A5044439908 @default.
- W4307155457 date "2023-01-01" @default.
- W4307155457 modified "2023-10-05" @default.
- W4307155457 title "Eosinophilic granulomatosis with polyangiitis: A review" @default.
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- W4307155457 doi "https://doi.org/10.1016/j.autrev.2022.103219" @default.
- W4307155457 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36283646" @default.
- W4307155457 hasPublicationYear "2023" @default.
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