FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4307156799> ?p ?o ?g. }

• W4307156799 abstract "RARRES1 is a tumor suppressor protein, and its expression is suppressed in various tumor cells. However, whether it participates in the immune response in kidney renal clear cell carcinoma (KIRC) is unknown, and the defined mechanism is not clear. Therefore, the mechanism of RARRES1 in KIRC is worthy of investigation.We analysed the expression and function of RARRES1 with The Cancer Genome Atlas (TCGA) database. The Kaplan-Meier curve was adopted to estimate survival. RARRES1-correlated genes were obtained from the UALCAN database and subjected to Gene Ontology (GO) enrichment and protein-protein interaction (PPI) network analyses. The correlation analysis between tumor-infiltrating immune cells and selected genes were performed with TIMER database. We also investigated the possible function of RARRES1 in KIRC by coculturing Caki-1 cells with THP-1 cells. Immunofluorescence assay was performed to study the RARRES1 expression in difference grade KIRC tissues.The expression of RARRES1 was negatively correlated with survival in KIRC patients. The GO biological process term most significantly enriched with the RARRES1-correlated genes was regulation of cell adhesion. ICAM1, which exhibited a relatively highest correlation with RARRES1, is positively correlated with the infiltration level of macrophages. RARRES1 could enhance the expression of ICAM1 in Caki-1 cells and then induce the activation of M1 THP-1 cells to decrease the viability and induce the apoptosis of Caki-1 cells.RARRES1 plays an antitumor role by promoting ICAM1 expression and inducing the activation of M1 macrophages. We offer insights into the molecular mechanism of KIRC and reveal a potential therapeutic target." @default.
• W4307156799 created "2022-10-28" @default.
• W4307156799 creator A5007354836 @default.
• W4307156799 creator A5028296024 @default.
• W4307156799 creator A5049689913 @default.
• W4307156799 creator A5056101043 @default.
• W4307156799 creator A5060135800 @default.
• W4307156799 creator A5068122140 @default.
• W4307156799 creator A5069609072 @default.
• W4307156799 creator A5072671101 @default.
• W4307156799 creator A5081020266 @default.
• W4307156799 creator A5082579923 @default.
• W4307156799 date "2022-10-24" @default.
• W4307156799 modified "2023-10-06" @default.
• W4307156799 title "Interaction of RARRES1 with ICAM1 modulates macrophages to suppress the progression of kidney renal clear cell carcinoma" @default.
• W4307156799 cites W2064475402 @default.
• W4307156799 cites W2082046119 @default.
• W4307156799 cites W2119097383 @default.
• W4307156799 cites W2133936352 @default.
• W4307156799 cites W2159560463 @default.
• W4307156799 cites W2588248604 @default.
• W4307156799 cites W2736730167 @default.
• W4307156799 cites W2741304577 @default.
• W4307156799 cites W2765224588 @default.
• W4307156799 cites W2768068475 @default.
• W4307156799 cites W2768266570 @default.
• W4307156799 cites W2806189174 @default.
• W4307156799 cites W2914311347 @default.
• W4307156799 cites W2918777009 @default.
• W4307156799 cites W2928665623 @default.
• W4307156799 cites W2937441321 @default.
• W4307156799 cites W2942006740 @default.
• W4307156799 cites W2944670712 @default.
• W4307156799 cites W2972294778 @default.
• W4307156799 cites W2988018593 @default.
• W4307156799 cites W2997983547 @default.
• W4307156799 cites W3004763252 @default.
• W4307156799 cites W3010838109 @default.
• W4307156799 cites W3013844766 @default.
• W4307156799 cites W3094730384 @default.
• W4307156799 cites W3183855250 @default.
• W4307156799 cites W3186986808 @default.
• W4307156799 cites W3194302859 @default.
• W4307156799 cites W3196714132 @default.
• W4307156799 cites W3203266881 @default.
• W4307156799 cites W4212990348 @default.
• W4307156799 cites W4220884623 @default.
• W4307156799 cites W4221029317 @default.
• W4307156799 cites W4223477555 @default.
• W4307156799 cites W4281756487 @default.
• W4307156799 doi "https://doi.org/10.3389/fimmu.2022.982045" @default.
• W4307156799 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36353618" @default.
• W4307156799 hasPublicationYear "2022" @default.
• W4307156799 type Work @default.
• W4307156799 citedByCount "1" @default.
• W4307156799 countsByYear W43071567992023 @default.
• W4307156799 crossrefType "journal-article" @default.
• W4307156799 hasAuthorship W4307156799A5007354836 @default.
• W4307156799 hasAuthorship W4307156799A5028296024 @default.
• W4307156799 hasAuthorship W4307156799A5049689913 @default.
• W4307156799 hasAuthorship W4307156799A5056101043 @default.
• W4307156799 hasAuthorship W4307156799A5060135800 @default.
• W4307156799 hasAuthorship W4307156799A5068122140 @default.
• W4307156799 hasAuthorship W4307156799A5069609072 @default.
• W4307156799 hasAuthorship W4307156799A5072671101 @default.
• W4307156799 hasAuthorship W4307156799A5081020266 @default.
• W4307156799 hasAuthorship W4307156799A5082579923 @default.
• W4307156799 hasBestOaLocation W43071567991 @default.
• W4307156799 hasConcept C104317684 @default.
• W4307156799 hasConcept C190283241 @default.
• W4307156799 hasConcept C203014093 @default.
• W4307156799 hasConcept C2780091579 @default.
• W4307156799 hasConcept C502942594 @default.
• W4307156799 hasConcept C54355233 @default.
• W4307156799 hasConcept C86803240 @default.
• W4307156799 hasConcept C8891405 @default.
• W4307156799 hasConcept C95444343 @default.
• W4307156799 hasConceptScore W4307156799C104317684 @default.
• W4307156799 hasConceptScore W4307156799C190283241 @default.
• W4307156799 hasConceptScore W4307156799C203014093 @default.
• W4307156799 hasConceptScore W4307156799C2780091579 @default.
• W4307156799 hasConceptScore W4307156799C502942594 @default.
• W4307156799 hasConceptScore W4307156799C54355233 @default.
• W4307156799 hasConceptScore W4307156799C86803240 @default.
• W4307156799 hasConceptScore W4307156799C8891405 @default.
• W4307156799 hasConceptScore W4307156799C95444343 @default.
• W4307156799 hasLocation W43071567991 @default.
• W4307156799 hasLocation W43071567992 @default.
• W4307156799 hasLocation W43071567993 @default.
• W4307156799 hasOpenAccess W4307156799 @default.
• W4307156799 hasPrimaryLocation W43071567991 @default.
• W4307156799 hasRelatedWork W2009966535 @default.
• W4307156799 hasRelatedWork W2019988726 @default.
• W4307156799 hasRelatedWork W2082530227 @default.
• W4307156799 hasRelatedWork W2088063203 @default.
• W4307156799 hasRelatedWork W2171277769 @default.
• W4307156799 hasRelatedWork W2349238733 @default.
• W4307156799 hasRelatedWork W2354530835 @default.
• W4307156799 hasRelatedWork W2367401676 @default.
• W4307156799 hasRelatedWork W2805121851 @default.

• next