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• W4307184354 abstract "Abstract Background: Ventilator-associated pneumonia (VAP) is a significant and common health concern, and epidemiological landscape of VAP is poorly understood in neurosurgery. The current study aimed to explore the epidemiology of VAP in neurosurgery to devise better-targeted surveillance, treatment and control efforts. Methods: A ten-year retrospective study was performed in a large Chinese tertiary hospital. We collected surveillance data on neurosurgical patients with VAP and used descriptive analysis to map the demographic and clinical characteristics of VAP as well as the distribution and antimicrobial resistance profile of leading pathogens. Risk factors associated with VAP were explored using boosted regression tree (BRT) models. Results: During 2011-2020, 310 VAP patients were identified. The ten-year incidence of VAP was 16.21 per 1000 ventilation days with an all-cause mortality rate of 6.1%. The proportions of gram-negative bacteria, fungi, and gram-positive bacteria in 357 isolates from 310 VAP patients were 86.0%, 7.6% and 6.4%, and most were multidrug-resistant organisms. Acinetobacter baumannii, Klebsiella pneumoniae , and Pseudomonas aeruginosa were the most common pathogens causing VAP, and high detection rates of CRAB, CRPA and CRKP with an upward trend were observed. The BRT modes revealed that there were significant associations of VAP presence with the days of ventilator use (relative contribution: 47.84 ± 7.25), GCS score (relative contribution: 24.72± 5.67), and tracheotomy (relative contribution: 21.50 ± 2.69), respectively. Conclusions: Our findings better understand epidemiological characteristics and risk factors for VAP in neurosurgery." @default.
• W4307184354 created "2022-10-29" @default.
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• W4307184354 date "2022-10-24" @default.
• W4307184354 modified "2023-10-13" @default.
• W4307184354 title "The Epidemiological Characteristics of Ventilator-associated Pneumonia in Neurosurgery: A Ten-year Surveillance Study in A Large Chinese Tertiary Hospital" @default.
• W4307184354 doi "https://doi.org/10.21203/rs.3.rs-2064581/v2" @default.
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