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- W4307187643 abstract "This chapter discusses the general background of post-mortem genetic and genomic testing and provides a detailed discussion of the application of these methods in the investigation of toxicology and cardiovascular disease & related deaths. The determination of what is the right dose; and in some cases, what is even the right drug for a given individual constitutes the reason for the development of the sciences of pharmacogenetics and pharmacogenomics. The beginning of pharmacogenetics can be traced to early observations in the 1950s, when it was realized that the antimalarial drug primaquine caused intravascular hemolysis in about 10% of African Americans but rarely among Caucasians. Recent years have seen a great deal of interest and research dedicated towards pharmacogenetics and pharmacogenomics. In general, pharmacogenomics refers to the study of many different genes that determine drug behavior, and pharmacogenetics refers to the study of inherited variations in drug metabolism and response." @default.
- W4307187643 created "2022-10-29" @default.
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- W4307187643 date "2022-10-24" @default.
- W4307187643 modified "2023-09-23" @default.
- W4307187643 title "Genetics in Death Investigations" @default.
- W4307187643 doi "https://doi.org/10.4324/9781315155159-5" @default.
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