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- W4307201611 abstract "Summary The epidermal growth factor receptor (EGFR) is a poster child for the understanding of receptor behaviour, and of paramount importance to cell function and human health. Cloned almost forty years ago, the interest in EGFR's structure/function relationships remains unabated, not least because changes in oncogenic EGFR mutants are key drivers of the formation of lung and brain tumours. The structure of the assemblies formed by EGFR have been comprehensibly investigated by techniques such as high‐resolution X‐ray crystallography, NMR and all‐atom molecular dynamics (MD) simulations. However, the complexity embedded in the portfolio of EGFR states that are only possible in the physiological environment of cells has often proved refractory to cell‐free structural methods. Conversely, some key inroads made by quantitative fluorescence microscopy and super‐resolution have depended on exploiting the wealth of structures available. Here, a brief personal perspective is provided on how quantitative fluorescence microscopy and super‐resolution methods have cross‐fertilised with cell‐free‐derived EGFR structural information. I primarily discuss areas in which my research group has made a contribution to fill gaps in EGFR's cellular structural biology and towards developing new tools to investigate macromolecular assemblies in cells." @default.
- W4307201611 created "2022-10-30" @default.
- W4307201611 creator A5082155061 @default.
- W4307201611 date "2022-11-04" @default.
- W4307201611 modified "2023-10-14" @default.
- W4307201611 title "A perspective of fluorescence microscopy for cellular structural biology with EGFR as witness" @default.
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- W4307201611 doi "https://doi.org/10.1111/jmi.13151" @default.
- W4307201611 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36282005" @default.
- W4307201611 hasPublicationYear "2022" @default.
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