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• W4307210649 endingPage "111334" @default.
• W4307210649 startingPage "111334" @default.
• W4307210649 abstract "The COVID-19 pandemic has underscored the need to understand the dynamics of SARS-CoV-2 respiratory infection and protection provided by the immune response. SARS-CoV-2 infections are characterized by a particularly high viral load, and further by the small number of inhaled virions sufficient to generate a high viral titer in the nasal passage a few days after exposure. SARS-CoV-2 specific antibodies (Ab), induced from vaccines, previous infection, or inhaled monoclonal Ab, have proven effective against SARS-CoV-2 infection. Our goal in this work is to model the protective mechanisms that Ab can provide and to assess the degree of protection from individual and combined mechanisms at different locations in the respiratory tract. Neutralization, in which Ab bind to virion spikes and inhibit them from binding to and infecting target cells, is one widely reported protective mechanism. A second mechanism of Ab protection is muco-trapping, in which Ab crosslink virions to domains on mucin polymers, effectively immobilizing them in the mucus layer. When muco-trapped, the continuous clearance of the mucus barrier by coordinated ciliary propulsion entrains the trapped viral load toward the esophagus to be swallowed. We model and simulate the protection provided by either and both mechanisms at different locations in the respiratory tract, parametrized by the Ab titer and binding-unbinding rates of Ab to viral spikes and mucin domains. Our results illustrate limits in the degree of protection by neutralizing Ab alone, the powerful protection afforded by muco-trapping Ab, and the potential for dual protection by muco-trapping and neutralizing Ab to arrest a SARS-CoV-2 infection. This manuscript was submitted as part of a theme issue on Modelling COVID-19 and Preparedness for Future Pandemics." @default.
• W4307210649 created "2022-10-30" @default.
• W4307210649 creator A5030886600 @default.
• W4307210649 creator A5036074139 @default.
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• W4307210649 date "2023-01-01" @default.
• W4307210649 modified "2023-10-05" @default.
• W4307210649 title "Antibody protection from SARS-CoV-2 respiratory tract exposure and infection" @default.
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• W4307210649 doi "https://doi.org/10.1016/j.jtbi.2022.111334" @default.
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