FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4307226503> ?p ?o ?g. }

• W4307226503 abstract "Testicular ischaemia reperfusion (I/R) injury results with serious dysfunctions in testis. This study aims to explore effects of soluble guanylate cyclase (sGC) stimulator Riociguat on experimental testicular I/R injury in rats. Twenty-one male rats were divided into three groups (Control, IR and IRR). The control group was not exposed to any application. Bilateral testis from IR and IRR animals were rotated 720° in opposite directions for 3 h to induce experimental testicular ischaemia. Animals in IR and IRR groups were subjected to 3 h of reperfusion. Isotonic and Riociguat were administered to the animals 30 min prior reperfusion by oral gavage. At the end of experiment, animals were sacrificed and tissue samples were used for analyses. Riociguat treatment significantly decreased tissue malondialdehyde and Luminol levels compared to the IR group (p < 0.05). The pathological changes, pro-apoptotic proteins (Bax, Caspase 3, and Caspase 9) and apoptotic index in the IR group were down regulated in Riociguat treated animals (p < 0.05). Riociguat treatment was also significantly increased anti-apoptotic Bcl-2 expression, but alleviated tissue injury via modulating pro-inflammatory cytokine IL-1β levels and significantly (p < 0.05) down-regulating NF-κB activity. Moreover, mTOR and ERK phosphorylation increased in IR group (p < 0.05), but Riociguat treatment reduced protein phosphorylation. Our experiment indicated that targeting sGC might support surgical interventions in testicular I/R injury by modulating oxidative stress, inflammation, and apoptotic protein expression levels, but more detailed studies are required to explore the protective activity of Riociguat and underlying mechanisms in testicular I/R injury." @default.
• W4307226503 created "2022-10-30" @default.
• W4307226503 creator A5009088727 @default.
• W4307226503 creator A5011376444 @default.
• W4307226503 creator A5035444498 @default.
• W4307226503 creator A5050694300 @default.
• W4307226503 creator A5051046633 @default.
• W4307226503 creator A5067202925 @default.
• W4307226503 creator A5080982394 @default.
• W4307226503 creator A5084169596 @default.
• W4307226503 date "2022-10-25" @default.
• W4307226503 modified "2023-09-30" @default.
• W4307226503 title "Targeting soluble guanylate cyclase with Riociguat has potency to alleviate testicular ischaemia reperfusion injury via regulating various cellular pathways" @default.
• W4307226503 cites W1530421518 @default.
• W4307226503 cites W182778844 @default.
• W4307226503 cites W2009001450 @default.
• W4307226503 cites W2028597443 @default.
• W4307226503 cites W2075282777 @default.
• W4307226503 cites W2094051883 @default.
• W4307226503 cites W2124393451 @default.
• W4307226503 cites W2151493966 @default.
• W4307226503 cites W2316225064 @default.
• W4307226503 cites W2531712020 @default.
• W4307226503 cites W2563703915 @default.
• W4307226503 cites W2598678077 @default.
• W4307226503 cites W2761909394 @default.
• W4307226503 cites W2767765728 @default.
• W4307226503 cites W2781852782 @default.
• W4307226503 cites W2793448482 @default.
• W4307226503 cites W2808584198 @default.
• W4307226503 cites W2832545210 @default.
• W4307226503 cites W2885478105 @default.
• W4307226503 cites W2898359156 @default.
• W4307226503 cites W2909214678 @default.
• W4307226503 cites W2915432665 @default.
• W4307226503 cites W2949714132 @default.
• W4307226503 cites W2967476539 @default.
• W4307226503 cites W2969802327 @default.
• W4307226503 cites W2972217041 @default.
• W4307226503 cites W2998117498 @default.
• W4307226503 cites W3033364661 @default.
• W4307226503 cites W3047498876 @default.
• W4307226503 cites W3090104643 @default.
• W4307226503 cites W3091713160 @default.
• W4307226503 cites W3101072710 @default.
• W4307226503 cites W3107402251 @default.
• W4307226503 cites W3114952911 @default.
• W4307226503 cites W3137764324 @default.
• W4307226503 cites W3152961402 @default.
• W4307226503 cites W3157030715 @default.
• W4307226503 cites W3164610060 @default.
• W4307226503 cites W3166168423 @default.
• W4307226503 cites W3185437220 @default.
• W4307226503 cites W3194984079 @default.
• W4307226503 cites W3196036761 @default.
• W4307226503 cites W4220923512 @default.
• W4307226503 cites W4225258033 @default.
• W4307226503 cites W4247766583 @default.
• W4307226503 cites W51382797 @default.
• W4307226503 doi "https://doi.org/10.1111/and.14616" @default.
• W4307226503 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36283690" @default.
• W4307226503 hasPublicationYear "2022" @default.
• W4307226503 type Work @default.
• W4307226503 citedByCount "0" @default.
• W4307226503 crossrefType "journal-article" @default.
• W4307226503 hasAuthorship W4307226503A5009088727 @default.
• W4307226503 hasAuthorship W4307226503A5011376444 @default.
• W4307226503 hasAuthorship W4307226503A5035444498 @default.
• W4307226503 hasAuthorship W4307226503A5050694300 @default.
• W4307226503 hasAuthorship W4307226503A5051046633 @default.
• W4307226503 hasAuthorship W4307226503A5067202925 @default.
• W4307226503 hasAuthorship W4307226503A5080982394 @default.
• W4307226503 hasAuthorship W4307226503A5084169596 @default.
• W4307226503 hasConcept C126322002 @default.
• W4307226503 hasConcept C134018914 @default.
• W4307226503 hasConcept C16685009 @default.
• W4307226503 hasConcept C173803235 @default.
• W4307226503 hasConcept C190283241 @default.
• W4307226503 hasConcept C2776151105 @default.
• W4307226503 hasConcept C2776304953 @default.
• W4307226503 hasConcept C2776914184 @default.
• W4307226503 hasConcept C2778401633 @default.
• W4307226503 hasConcept C2780114680 @default.
• W4307226503 hasConcept C519581460 @default.
• W4307226503 hasConcept C541997718 @default.
• W4307226503 hasConcept C55493867 @default.
• W4307226503 hasConcept C71924100 @default.
• W4307226503 hasConcept C86803240 @default.
• W4307226503 hasConcept C98274493 @default.
• W4307226503 hasConceptScore W4307226503C126322002 @default.
• W4307226503 hasConceptScore W4307226503C134018914 @default.
• W4307226503 hasConceptScore W4307226503C16685009 @default.
• W4307226503 hasConceptScore W4307226503C173803235 @default.
• W4307226503 hasConceptScore W4307226503C190283241 @default.
• W4307226503 hasConceptScore W4307226503C2776151105 @default.
• W4307226503 hasConceptScore W4307226503C2776304953 @default.
• W4307226503 hasConceptScore W4307226503C2776914184 @default.
• W4307226503 hasConceptScore W4307226503C2778401633 @default.
• W4307226503 hasConceptScore W4307226503C2780114680 @default.
• W4307226503 hasConceptScore W4307226503C519581460 @default.

• next