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- W4307228886 endingPage "1352" @default.
- W4307228886 startingPage "1341" @default.
- W4307228886 abstract "Extracellular signal-related kinases 1 and 2 (ERK1/2) are the final components of the mitogen-activated protein kinase (MAPK) phosphorylation cascade, an integral module in a diverse array of signalling pathways for shaping cell behaviour and fate. More recently, studies have shown that ERK1/2 plays an essential role downstream of immune receptors to elicit inflammatory gene expression in response to infection and cell or tissue damage. Much of this work has studied ERK1/2 activation in Toll-like receptor (TLR) pathways, providing mechanistic insights into its recruitment, compartmentalisation and activation in cells of the innate immune system. In this review, we summarise the typical activation of ERK1/2 in growth factor receptor pathways before discussing its known roles in immune cell signalling with a focus downstream of TLRs. We examine emerging research uncovering evidence of dysfunctional ERK1/2 signalling in inflammatory diseases and discuss the potential therapeutic benefit of targeting ERK1/2 pathways in inflammation." @default.
- W4307228886 created "2022-10-30" @default.
- W4307228886 creator A5002937111 @default.
- W4307228886 creator A5023814339 @default.
- W4307228886 creator A5037595118 @default.
- W4307228886 date "2022-10-25" @default.
- W4307228886 modified "2023-10-14" @default.
- W4307228886 title "ERK1/2 in immune signalling" @default.
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