Matches in SemOpenAlex for { <https://semopenalex.org/work/W4307229478> ?p ?o ?g. }
- W4307229478 endingPage "366" @default.
- W4307229478 startingPage "354" @default.
- W4307229478 abstract "Endoplasmic reticulum (ER) stress and beta cell dedifferentiation both play leading roles in impaired insulin secretion in overt type 2 diabetes. Whether and how these factors are related in the natural history of the disease remains, however, unclear.In this study, we analysed pancreas biopsies from a cohort of metabolically characterised living donors to identify defects in in situ insulin synthesis and intra-islet expression of ER stress and beta cell phenotype markers.We provide evidence that in situ altered insulin processing is closely connected to in vivo worsening of beta cell function. Further, activation of ER stress genes reflects the alteration of insulin processing in situ. Using a combination of 17 different markers, we characterised individual pancreatic islets from normal glucose tolerant, impaired glucose tolerant and type 2 diabetic participants and reconstructed disease progression.Our study suggests that increased beta cell workload is accompanied by a progressive increase in ER stress with defects in insulin synthesis and loss of beta cell identity." @default.
- W4307229478 created "2022-10-30" @default.
- W4307229478 creator A5011634368 @default.
- W4307229478 creator A5013586361 @default.
- W4307229478 creator A5017924398 @default.
- W4307229478 creator A5023823792 @default.
- W4307229478 creator A5030711404 @default.
- W4307229478 creator A5031169596 @default.
- W4307229478 creator A5038004155 @default.
- W4307229478 creator A5038957918 @default.
- W4307229478 creator A5040035539 @default.
- W4307229478 creator A5045481423 @default.
- W4307229478 creator A5048228010 @default.
- W4307229478 creator A5063027844 @default.
- W4307229478 creator A5064268494 @default.
- W4307229478 creator A5069364785 @default.
- W4307229478 creator A5069554598 @default.
- W4307229478 creator A5071134404 @default.
- W4307229478 creator A5076259830 @default.
- W4307229478 creator A5081762535 @default.
- W4307229478 creator A5088220553 @default.
- W4307229478 creator A5091886237 @default.
- W4307229478 date "2022-10-25" @default.
- W4307229478 modified "2023-10-17" @default.
- W4307229478 title "Intra-islet insulin synthesis defects are associated with endoplasmic reticulum stress and loss of beta cell identity in human diabetes" @default.
- W4307229478 cites W1669198251 @default.
- W4307229478 cites W1921578357 @default.
- W4307229478 cites W1965469192 @default.
- W4307229478 cites W1997520810 @default.
- W4307229478 cites W1998802885 @default.
- W4307229478 cites W2025682280 @default.
- W4307229478 cites W2028113047 @default.
- W4307229478 cites W2030702380 @default.
- W4307229478 cites W2046120487 @default.
- W4307229478 cites W2049270390 @default.
- W4307229478 cites W2061574308 @default.
- W4307229478 cites W2069409352 @default.
- W4307229478 cites W2112902148 @default.
- W4307229478 cites W2124368774 @default.
- W4307229478 cites W2133222023 @default.
- W4307229478 cites W2133795831 @default.
- W4307229478 cites W2151409811 @default.
- W4307229478 cites W2167357721 @default.
- W4307229478 cites W2192832911 @default.
- W4307229478 cites W2199891677 @default.
- W4307229478 cites W2326475098 @default.
- W4307229478 cites W2520989770 @default.
- W4307229478 cites W2523499310 @default.
- W4307229478 cites W2581716463 @default.
- W4307229478 cites W2888559318 @default.
- W4307229478 cites W2890120255 @default.
- W4307229478 cites W2913671661 @default.
- W4307229478 cites W2933738638 @default.
- W4307229478 cites W2946154760 @default.
- W4307229478 cites W2953056615 @default.
- W4307229478 cites W2972106254 @default.
- W4307229478 cites W2973236841 @default.
- W4307229478 cites W3017817590 @default.
- W4307229478 cites W3026838429 @default.
- W4307229478 cites W3126935384 @default.
- W4307229478 cites W3158076751 @default.
- W4307229478 cites W3158921277 @default.
- W4307229478 cites W3196268865 @default.
- W4307229478 cites W3212218265 @default.
- W4307229478 cites W4220863972 @default.
- W4307229478 doi "https://doi.org/10.1007/s00125-022-05814-2" @default.
- W4307229478 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36280617" @default.
- W4307229478 hasPublicationYear "2022" @default.
- W4307229478 type Work @default.
- W4307229478 citedByCount "6" @default.
- W4307229478 countsByYear W43072294782022 @default.
- W4307229478 countsByYear W43072294782023 @default.
- W4307229478 crossrefType "journal-article" @default.
- W4307229478 hasAuthorship W4307229478A5011634368 @default.
- W4307229478 hasAuthorship W4307229478A5013586361 @default.
- W4307229478 hasAuthorship W4307229478A5017924398 @default.
- W4307229478 hasAuthorship W4307229478A5023823792 @default.
- W4307229478 hasAuthorship W4307229478A5030711404 @default.
- W4307229478 hasAuthorship W4307229478A5031169596 @default.
- W4307229478 hasAuthorship W4307229478A5038004155 @default.
- W4307229478 hasAuthorship W4307229478A5038957918 @default.
- W4307229478 hasAuthorship W4307229478A5040035539 @default.
- W4307229478 hasAuthorship W4307229478A5045481423 @default.
- W4307229478 hasAuthorship W4307229478A5048228010 @default.
- W4307229478 hasAuthorship W4307229478A5063027844 @default.
- W4307229478 hasAuthorship W4307229478A5064268494 @default.
- W4307229478 hasAuthorship W4307229478A5069364785 @default.
- W4307229478 hasAuthorship W4307229478A5069554598 @default.
- W4307229478 hasAuthorship W4307229478A5071134404 @default.
- W4307229478 hasAuthorship W4307229478A5076259830 @default.
- W4307229478 hasAuthorship W4307229478A5081762535 @default.
- W4307229478 hasAuthorship W4307229478A5088220553 @default.
- W4307229478 hasAuthorship W4307229478A5091886237 @default.
- W4307229478 hasBestOaLocation W43072294781 @default.
- W4307229478 hasConcept C126322002 @default.
- W4307229478 hasConcept C134018914 @default.
- W4307229478 hasConcept C139447449 @default.
- W4307229478 hasConcept C158617107 @default.