FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4307250215> ?p ?o ?g. }

• W4307250215 abstract "Abstract Nicotine is an addictive drug whose popularity has recently increased, particularly among adolescents, due to the availability of electronic nicotine devices ( i . e ., “vaping”) and nicotine e-liquids containing additives with rich chemosensory properties. Some efforts to understand the role of these additives in nicotine reward suggest that they increase nicotine reward and reinforcement, but the sensory contributions of additives, especially in their vapor forms, are largely untested. Here, to better understand how a fruit-flavored ( i . e ., strawberry) additive influences nicotine reward and aversion, we used a conditioned place preference (CPP) procedure in which nicotine and a strawberry additive were delivered as a vapor to male and female adolescent mice. We found that nicotine vapor alone can lead to dose-dependent CPP when using a biased design. The strawberry additive did not produce CPP on its own, and we did not observe an effect of the strawberry additive on nicotine vapor-induced reward. Nevertheless, mice exposed to nicotine + strawberry additive vapor had higher plasma cotinine concentrations, which did not appear to reflect altered nicotine metabolism. Instead, by directly measuring vapor sampling through respiration monitoring, we uncovered an increase in the amount of sniffing toward strawberry-containing nicotine vapor compared to nicotine vapor alone. Together these data indicate that chemosensory-rich e-liquid additives may enhance the perceived sensory profile of nicotine vapors rather than the reward value per se , which leads to overall increased nicotine exposure. Significance Statement With the rise in popularity of flavored e-cigarette products, many have considered the possibility that flavor volatiles will enhance nicotine reward; however, the possibility that flavor additives have chemosensory properties that can affect nicotine intake has been largely overlooked. Here, by delivering nicotine to adolescent mice as a vapor we were able to consider both possibilities. We found that mice had increased sniffing intensity and nicotine exposure when vapors contained a strawberry additive, despite the fact that the same additive was unable to enhance Pavlovian nicotine reward using a CPP paradigm. This research highlights the importance of considering the chemosensory properties of e-cigarette additives as a mechanism for their effect on nicotine use." @default.
• W4307250215 created "2022-10-30" @default.
• W4307250215 creator A5005046523 @default.
• W4307250215 creator A5008933713 @default.
• W4307250215 creator A5014027463 @default.
• W4307250215 creator A5029810189 @default.
• W4307250215 creator A5040019732 @default.
• W4307250215 creator A5058291614 @default.
• W4307250215 creator A5067574403 @default.
• W4307250215 creator A5089699394 @default.
• W4307250215 date "2022-10-21" @default.
• W4307250215 modified "2023-10-16" @default.
• W4307250215 title "Strawberry additive increases nicotine vapor sampling and systemic exposure but does not enhance Pavlovian-based nicotine reward in mice" @default.
• W4307250215 cites W1969939237 @default.
• W4307250215 cites W1980040785 @default.
• W4307250215 cites W1995599717 @default.
• W4307250215 cites W1997679425 @default.
• W4307250215 cites W2000430248 @default.
• W4307250215 cites W2013138457 @default.
• W4307250215 cites W2019596363 @default.
• W4307250215 cites W2039944259 @default.
• W4307250215 cites W2054228603 @default.
• W4307250215 cites W2065974708 @default.
• W4307250215 cites W2079375209 @default.
• W4307250215 cites W2085734568 @default.
• W4307250215 cites W2086941401 @default.
• W4307250215 cites W2089375097 @default.
• W4307250215 cites W2092908361 @default.
• W4307250215 cites W2100776577 @default.
• W4307250215 cites W2101673955 @default.
• W4307250215 cites W2105617092 @default.
• W4307250215 cites W2110690897 @default.
• W4307250215 cites W2114217405 @default.
• W4307250215 cites W2123130395 @default.
• W4307250215 cites W2125937217 @default.
• W4307250215 cites W2149765291 @default.
• W4307250215 cites W2151606867 @default.
• W4307250215 cites W2167371136 @default.
• W4307250215 cites W2195900341 @default.
• W4307250215 cites W2320293868 @default.
• W4307250215 cites W2396233551 @default.
• W4307250215 cites W2401638570 @default.
• W4307250215 cites W2475216952 @default.
• W4307250215 cites W2520295263 @default.
• W4307250215 cites W2520952191 @default.
• W4307250215 cites W2521692608 @default.
• W4307250215 cites W2528786349 @default.
• W4307250215 cites W2698106459 @default.
• W4307250215 cites W2727967967 @default.
• W4307250215 cites W2791164569 @default.
• W4307250215 cites W2793265743 @default.
• W4307250215 cites W2806596446 @default.
• W4307250215 cites W2914917410 @default.
• W4307250215 cites W2915828976 @default.
• W4307250215 cites W2965542329 @default.
• W4307250215 cites W2965770623 @default.
• W4307250215 cites W2983597667 @default.
• W4307250215 cites W2986171322 @default.
• W4307250215 cites W2996178956 @default.
• W4307250215 cites W3004319223 @default.
• W4307250215 cites W3029776716 @default.
• W4307250215 cites W3082817511 @default.
• W4307250215 cites W3163291248 @default.
• W4307250215 doi "https://doi.org/10.1101/2022.10.19.512743" @default.
• W4307250215 hasPublicationYear "2022" @default.
• W4307250215 type Work @default.
• W4307250215 citedByCount "0" @default.
• W4307250215 crossrefType "posted-content" @default.
• W4307250215 hasAuthorship W4307250215A5005046523 @default.
• W4307250215 hasAuthorship W4307250215A5008933713 @default.
• W4307250215 hasAuthorship W4307250215A5014027463 @default.
• W4307250215 hasAuthorship W4307250215A5029810189 @default.
• W4307250215 hasAuthorship W4307250215A5040019732 @default.
• W4307250215 hasAuthorship W4307250215A5058291614 @default.
• W4307250215 hasAuthorship W4307250215A5067574403 @default.
• W4307250215 hasAuthorship W4307250215A5089699394 @default.
• W4307250215 hasBestOaLocation W43072502151 @default.
• W4307250215 hasConcept C15744967 @default.
• W4307250215 hasConcept C169760540 @default.
• W4307250215 hasConcept C178790620 @default.
• W4307250215 hasConcept C185592680 @default.
• W4307250215 hasConcept C2776319443 @default.
• W4307250215 hasConcept C2777667214 @default.
• W4307250215 hasConcept C2779547902 @default.
• W4307250215 hasConcept C35124327 @default.
• W4307250215 hasConcept C48856860 @default.
• W4307250215 hasConcept C71924100 @default.
• W4307250215 hasConcept C98274493 @default.
• W4307250215 hasConceptScore W4307250215C15744967 @default.
• W4307250215 hasConceptScore W4307250215C169760540 @default.
• W4307250215 hasConceptScore W4307250215C178790620 @default.
• W4307250215 hasConceptScore W4307250215C185592680 @default.
• W4307250215 hasConceptScore W4307250215C2776319443 @default.
• W4307250215 hasConceptScore W4307250215C2777667214 @default.
• W4307250215 hasConceptScore W4307250215C2779547902 @default.
• W4307250215 hasConceptScore W4307250215C35124327 @default.
• W4307250215 hasConceptScore W4307250215C48856860 @default.
• W4307250215 hasConceptScore W4307250215C71924100 @default.
• W4307250215 hasConceptScore W4307250215C98274493 @default.
• W4307250215 hasLocation W43072502151 @default.

• next