FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4307275229> ?p ?o ?g. }

• W4307275229 abstract "Abstract Macrophages are important components in modulating homeostatic and inflammatory responses and are generally categorized into two broad but distinct subsets: classical activated (M1) and alternatively activated (M2) depending on the microenvironment. Fibrosis is a chronic inflammatory disease exacerbated by M2 macrophages, although the detailed mechanism by which M2 macrophage polarization is regulated remains unclear. These polarization mechanisms have little in common between mice and humans, making it difficult to adapt research results obtained in mice to human diseases. Tissue transglutaminase (TG2) is a known marker common to mouse and human M2 macrophages and is a multifunctional enzyme responsible for crosslinking reactions. Here we sought to identify the role of TG2 in macrophage polarization and fibrosis. In IL-4-treated macrophages derived from mouse bone marrow and human monocyte cells, the expression of TG2 was increased with enhancement of M2 macrophage markers, whereas knockout or inhibitor treatment of TG2 markedly suppressed M2 macrophage polarization. In the renal fibrosis model, accumulation of M2 macrophages in fibrotic kidney was significantly reduced in TG2 knockout or inhibitor-administrated mice, along with the resolution of fibrosis. Bone marrow transplantation using TG2-knockout mice revealed that TG2 is involved in M2 polarization of infiltrating macrophages derived from circulating monocytes and exacerbates renal fibrosis. Furthermore, the suppression of renal fibrosis in TG2-knockout mice was abolished by transplantation of wild-type bone marrow or by renal subcapsular injection of IL4-treated macrophages derived from bone marrow of wild-type, but not TG2 knockout. Transcriptome analysis of downstream targets involved in M2 macrophages polarization revealed that ALOX15 expression was enhanced by TG2 activation and promoted M2 macrophage polarization. Furthermore, the increase in the abundance of ALOX15-expressing macrophages in fibrotic kidney was dramatically suppressed in TG2-knockout mice. These findings demonstrated that TG2 activity exacerbates renal fibrosis by polarization of M2 macrophages from monocytes via ALOX15." @default.
• W4307275229 created "2022-10-31" @default.
• W4307275229 creator A5015833872 @default.
• W4307275229 creator A5015939669 @default.
• W4307275229 creator A5022233501 @default.
• W4307275229 creator A5039900178 @default.
• W4307275229 creator A5042788588 @default.
• W4307275229 creator A5050243357 @default.
• W4307275229 creator A5051282847 @default.
• W4307275229 creator A5072081352 @default.
• W4307275229 creator A5089963919 @default.
• W4307275229 date "2022-10-24" @default.
• W4307275229 modified "2023-09-27" @default.
• W4307275229 title "Tissue transglutaminase exacerbates renal fibrosis via alternative activation of monocyte-derived macrophages" @default.
• W4307275229 cites W1204481820 @default.
• W4307275229 cites W1505047300 @default.
• W4307275229 cites W1560714476 @default.
• W4307275229 cites W1991112668 @default.
• W4307275229 cites W1993570315 @default.
• W4307275229 cites W1994247511 @default.
• W4307275229 cites W2015141049 @default.
• W4307275229 cites W2020744745 @default.
• W4307275229 cites W2023081206 @default.
• W4307275229 cites W2027065592 @default.
• W4307275229 cites W2031515819 @default.
• W4307275229 cites W2036806537 @default.
• W4307275229 cites W2060659287 @default.
• W4307275229 cites W2065377708 @default.
• W4307275229 cites W2072100568 @default.
• W4307275229 cites W2082973874 @default.
• W4307275229 cites W2094659815 @default.
• W4307275229 cites W2099262956 @default.
• W4307275229 cites W2103310208 @default.
• W4307275229 cites W2103627235 @default.
• W4307275229 cites W2109835881 @default.
• W4307275229 cites W2115337375 @default.
• W4307275229 cites W2131236880 @default.
• W4307275229 cites W2138919021 @default.
• W4307275229 cites W2141791865 @default.
• W4307275229 cites W2143394681 @default.
• W4307275229 cites W2151601135 @default.
• W4307275229 cites W2165240849 @default.
• W4307275229 cites W2174617543 @default.
• W4307275229 cites W2212468924 @default.
• W4307275229 cites W2255925370 @default.
• W4307275229 cites W2301038687 @default.
• W4307275229 cites W2529587038 @default.
• W4307275229 cites W2559257586 @default.
• W4307275229 cites W2562980016 @default.
• W4307275229 cites W2589113597 @default.
• W4307275229 cites W2603463796 @default.
• W4307275229 cites W2791806364 @default.
• W4307275229 cites W2806415943 @default.
• W4307275229 cites W2962741338 @default.
• W4307275229 cites W2978446784 @default.
• W4307275229 cites W3005817595 @default.
• W4307275229 cites W3129954143 @default.
• W4307275229 cites W3131840627 @default.
• W4307275229 cites W3178220160 @default.
• W4307275229 cites W3211239814 @default.
• W4307275229 cites W4200250462 @default.
• W4307275229 doi "https://doi.org/10.21203/rs.3.rs-2156542/v1" @default.
• W4307275229 hasPublicationYear "2022" @default.
• W4307275229 type Work @default.
• W4307275229 citedByCount "0" @default.
• W4307275229 crossrefType "posted-content" @default.
• W4307275229 hasAuthorship W4307275229A5015833872 @default.
• W4307275229 hasAuthorship W4307275229A5015939669 @default.
• W4307275229 hasAuthorship W4307275229A5022233501 @default.
• W4307275229 hasAuthorship W4307275229A5039900178 @default.
• W4307275229 hasAuthorship W4307275229A5042788588 @default.
• W4307275229 hasAuthorship W4307275229A5050243357 @default.
• W4307275229 hasAuthorship W4307275229A5051282847 @default.
• W4307275229 hasAuthorship W4307275229A5072081352 @default.
• W4307275229 hasAuthorship W4307275229A5089963919 @default.
• W4307275229 hasBestOaLocation W43072752291 @default.
• W4307275229 hasConcept C126322002 @default.
• W4307275229 hasConcept C134018914 @default.
• W4307275229 hasConcept C142724271 @default.
• W4307275229 hasConcept C170493617 @default.
• W4307275229 hasConcept C178498320 @default.
• W4307275229 hasConcept C181199279 @default.
• W4307275229 hasConcept C182704531 @default.
• W4307275229 hasConcept C202751555 @default.
• W4307275229 hasConcept C203014093 @default.
• W4307275229 hasConcept C2776682551 @default.
• W4307275229 hasConcept C2779244956 @default.
• W4307275229 hasConcept C2780007613 @default.
• W4307275229 hasConcept C2780091579 @default.
• W4307275229 hasConcept C2780559512 @default.
• W4307275229 hasConcept C2781184567 @default.
• W4307275229 hasConcept C2910375186 @default.
• W4307275229 hasConcept C502942594 @default.
• W4307275229 hasConcept C55493867 @default.
• W4307275229 hasConcept C71924100 @default.
• W4307275229 hasConcept C86803240 @default.
• W4307275229 hasConceptScore W4307275229C126322002 @default.
• W4307275229 hasConceptScore W4307275229C134018914 @default.
• W4307275229 hasConceptScore W4307275229C142724271 @default.
• W4307275229 hasConceptScore W4307275229C170493617 @default.

• next