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- W4307279653 abstract "Abstract Background: Ovarian cancer is one of the most lethal gynecologic malignancies with a dismal prognosis that poses a serious threat to human health, highlighting the need for more knowledge about what is required for identifying some biomarkers for early diagnosis, prediction of prognosis and disease monitoring. TOX, a critical transcription factor related to the development of malignancies that contributing to lymphocytes not just T cells, had been proved prognostic value in some spectrum of cancers. Here, we aimed to study the prognostic role of TOX in ovarian cancer. Results: We found that TOX was not only expressed in CD8 T cells but also tumor cells. TOX expression score was higher in ovarian cancer tissues and correlated with survival status. Survival analysis revealed that ovarian cancer patients with high TOX expression score generally shorter overall survival and disease-free survival times. Univariate and Multivariate Cox demonstrated that TOX expression score could be used as an independent prognostic factor for patients with ovarian cancer. Conclusion: TOX expression in ovarian cancer could be a promising tool for predict overall survival of ovarian cancer patients." @default.
- W4307279653 created "2022-10-31" @default.
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- W4307279653 date "2022-10-24" @default.
- W4307279653 modified "2023-09-27" @default.
- W4307279653 title "Higher TOX（Thymocyte selection-associated high mobility group box）expression in tumor microenvironment predicts poor prognosis in patients with ovarian cancer" @default.
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- W4307279653 doi "https://doi.org/10.21203/rs.3.rs-2027322/v2" @default.
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