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• W4307280610 abstract "Summary The cellular ability to react to environmental fluctuations depends on signaling networks that are controlled by the dynamic activities of kinases and phosphatases. To gain insight into these stress-responsive phosphorylation networks, we generated a quantitative mass spectrometry-based atlas of early phosphoproteomic responses in Saccharomyces cerevisiae exposed to 101 environmental and chemical perturbations. We report phosphosites on 59% of the yeast proteome, with 18% of the proteome harboring a phosphosite that is regulated within 5 minutes of stress exposure. We identify shared and perturbation-specific stress response programs, uncover dephosphorylation as an integral early event, and dissect the interconnected regulatory landscape of kinase-substrate networks, as we exemplify with TOR signaling. We further reveal functional organization principles of the stress-responsive phosphoproteome based on phosphorylation site motifs, kinase activities, subcellular localizations, shared functions, and pathway intersections. This information-rich map of 25,000 regulated phosphosites advances our understanding of signaling networks. Highlights Ultra-deep reference yeast phosphoproteome covers 36,000 phosphorylation sites and reveals general principles of eukaryotic protein phosphorylation. High-dimensional quantitative atlas of early phosphoproteomic responses of yeast across 101 environmental and chemical perturbations identifies 25,000 regulated perturbation-phosphosite pairs. Identification of shared and perturbation-specific stress response phosphorylation programs reveals the importance of dephosphorylation as an early stress response. Dissection of the TOR signaling network uncovers subnetworks with differential stress responsiveness and points of pathway cross-talk Identification of functional organization of the phosphoproteome by dimensionality reduction and co-regulation analysis." @default.
• W4307280610 created "2022-10-31" @default.
• W4307280610 creator A5005646080 @default.
• W4307280610 creator A5037313718 @default.
• W4307280610 creator A5073034119 @default.
• W4307280610 creator A5074646455 @default.
• W4307280610 creator A5090022399 @default.
• W4307280610 date "2022-10-24" @default.
• W4307280610 modified "2023-10-18" @default.
• W4307280610 title "The regulatory landscape of the yeast phosphoproteome" @default.
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• W4307280610 doi "https://doi.org/10.1101/2022.10.23.513432" @default.
• W4307280610 hasPublicationYear "2022" @default.
• W4307280610 type Work @default.
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• W4307280610 hasAuthorship W4307280610A5005646080 @default.
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• W4307280610 hasAuthorship W4307280610A5073034119 @default.

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