Matches in SemOpenAlex for { <https://semopenalex.org/work/W4307280817> ?p ?o ?g. }
- W4307280817 endingPage "12933" @default.
- W4307280817 startingPage "12933" @default.
- W4307280817 abstract "Adult skeletal muscle fibres are classified as type 1, 2A, 2X, and 2B. These classifications are based on the expression of the dominant myosin heavy chain isoform. Muscle fibre-specific gene expression and proportions of muscle fibre types change during development and in response to exercise, chronic electrical stimulation, or inactivity. To identify genes whose gain or loss-of-function alters type 1, 2A, 2X, or 2B muscle fibre proportions in mice, we conducted a systematic review of transgenic mouse studies. The systematic review was conducted in accordance with the 2009 PRISMA guidelines and the PICO framework. We identified 25 muscle fibre genes (Akirin1, Bdkrb2, Bdnf, Camk4, Ccnd3, Cpt1a, Epas1, Esrrg, Foxj3, Foxo1, Il15, Mapk12, Mstn, Myod1, Ncor1, Nfatc1, Nol3, Ppargc1a, Ppargc1b, Sirt1, Sirt3, Thra, Thrb, Trib3, and Vgll2) whose gain or loss-of-function significantly changes type 1, 2A, 2X or 2B muscle fibre proportions in mice. The fact that 15 of the 25 muscle fibre genes are transcriptional regulators suggests that muscle fibre-specific gene expression is primarily regulated transcriptionally. A reanalysis of existing datasets revealed that the expression of Ppargc1a and Vgll2 increases and Mstn decreases after exercise, respectively. This suggests that these genes help to regulate the muscle fibre adaptation to exercise. Finally, there are many known DNA sequence variants of muscle fibre genes. It seems likely that such DNA sequence variants contribute to the large variation of muscle fibre type proportions in the human population." @default.
- W4307280817 created "2022-10-31" @default.
- W4307280817 creator A5029054073 @default.
- W4307280817 creator A5035143218 @default.
- W4307280817 creator A5057233389 @default.
- W4307280817 creator A5057899222 @default.
- W4307280817 creator A5072611440 @default.
- W4307280817 creator A5079409047 @default.
- W4307280817 date "2022-10-26" @default.
- W4307280817 modified "2023-09-30" @default.
- W4307280817 title "Genes Whose Gain or Loss of Function Changes Type 1, 2A, 2X, or 2B Muscle Fibre Proportions in Mice—A Systematic Review" @default.
- W4307280817 cites W1512696907 @default.
- W4307280817 cites W1533942137 @default.
- W4307280817 cites W1567217814 @default.
- W4307280817 cites W1573544812 @default.
- W4307280817 cites W1605087646 @default.
- W4307280817 cites W1794386847 @default.
- W4307280817 cites W1839260472 @default.
- W4307280817 cites W1894420075 @default.
- W4307280817 cites W1899162081 @default.
- W4307280817 cites W1942265307 @default.
- W4307280817 cites W1946850348 @default.
- W4307280817 cites W1963939681 @default.
- W4307280817 cites W1967682606 @default.
- W4307280817 cites W1968897633 @default.
- W4307280817 cites W1969449476 @default.
- W4307280817 cites W1969628440 @default.
- W4307280817 cites W1971431411 @default.
- W4307280817 cites W1977166082 @default.
- W4307280817 cites W1979486745 @default.
- W4307280817 cites W1987131090 @default.
- W4307280817 cites W1989494494 @default.
- W4307280817 cites W1990828270 @default.
- W4307280817 cites W2001200242 @default.
- W4307280817 cites W2002030208 @default.
- W4307280817 cites W2004966039 @default.
- W4307280817 cites W2013601893 @default.
- W4307280817 cites W2023089345 @default.
- W4307280817 cites W2028225339 @default.
- W4307280817 cites W2028656620 @default.
- W4307280817 cites W2028716770 @default.
- W4307280817 cites W2030106008 @default.
- W4307280817 cites W2033561732 @default.
- W4307280817 cites W2035395303 @default.
- W4307280817 cites W2036145275 @default.
- W4307280817 cites W2042253908 @default.
- W4307280817 cites W2044275161 @default.
- W4307280817 cites W2052989289 @default.
- W4307280817 cites W2053765200 @default.
- W4307280817 cites W2056634233 @default.
- W4307280817 cites W2058712327 @default.
- W4307280817 cites W2071272599 @default.
- W4307280817 cites W2071994932 @default.
- W4307280817 cites W2074248426 @default.
- W4307280817 cites W2077853923 @default.
- W4307280817 cites W2083055314 @default.
- W4307280817 cites W2087408740 @default.
- W4307280817 cites W2093734656 @default.
- W4307280817 cites W2096207972 @default.
- W4307280817 cites W2099540110 @default.
- W4307280817 cites W2111722073 @default.
- W4307280817 cites W2114603492 @default.
- W4307280817 cites W2124649657 @default.
- W4307280817 cites W2136446317 @default.
- W4307280817 cites W2140994672 @default.
- W4307280817 cites W2141000092 @default.
- W4307280817 cites W2145303230 @default.
- W4307280817 cites W2146480641 @default.
- W4307280817 cites W2164713351 @default.
- W4307280817 cites W2166877291 @default.
- W4307280817 cites W2256016639 @default.
- W4307280817 cites W2329425391 @default.
- W4307280817 cites W2410292096 @default.
- W4307280817 cites W2618770807 @default.
- W4307280817 cites W2740937772 @default.
- W4307280817 cites W2745848337 @default.
- W4307280817 cites W2802418035 @default.
- W4307280817 cites W2804710503 @default.
- W4307280817 cites W2809057270 @default.
- W4307280817 cites W2888251992 @default.
- W4307280817 cites W2888623890 @default.
- W4307280817 cites W2900569176 @default.
- W4307280817 cites W2911765309 @default.
- W4307280817 cites W2923423430 @default.
- W4307280817 cites W2924950986 @default.
- W4307280817 cites W2959540491 @default.
- W4307280817 cites W3002380642 @default.
- W4307280817 cites W3087143447 @default.
- W4307280817 cites W3118615836 @default.
- W4307280817 cites W3144460008 @default.
- W4307280817 cites W3201364864 @default.
- W4307280817 cites W3210336483 @default.
- W4307280817 cites W3213156599 @default.
- W4307280817 cites W3216751011 @default.
- W4307280817 doi "https://doi.org/10.3390/ijms232112933" @default.
- W4307280817 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36361732" @default.
- W4307280817 hasPublicationYear "2022" @default.
- W4307280817 type Work @default.