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- W4307288311 endingPage "104925" @default.
- W4307288311 startingPage "104925" @default.
- W4307288311 abstract "Our study estimated size of impairment for different cognitive functions in early-treated adults with PKU (AwPKU) by combining literature results in a meta-analytic way. We analysed a large set of functions (N = 19), each probed by different measures (average = 12). Data were extracted from 26 PKU groups and matched controls, with 757 AwPKU contributing 220 measures. Effect sizes (ESs) were computed using Glass' ∆ where differences in performance between clinical/PKU and control groups are standardized using the mean and standard deviation of the control groups. Significance was assessed using measures nested within independent PKU groups as a random factor. The weighted Glass' ∆ was - 0.44 for all functions taken together, and - 0.60 for IQ, both highly significant. Separate, significant impairments were found for most functions, but with great variability (ESs from -1.02 to -0.18). The most severe impairments were in reasoning, visual-spatial attention speed, sustained attention, visuo-motor control, and flexibility. Effect sizes were larger with speed than accuracy measures, and with visuo-spatial than verbal stimuli. Results show a specific PKU profile that needs consideration when monitoring the disease." @default.
- W4307288311 created "2022-10-31" @default.
- W4307288311 creator A5010218352 @default.
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- W4307288311 creator A5082860887 @default.
- W4307288311 date "2022-12-01" @default.
- W4307288311 modified "2023-10-06" @default.
- W4307288311 title "Meta-analyses of cognitive functions in early-treated adults with phenylketonuria" @default.
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