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- W4307291228 endingPage "5245" @default.
- W4307291228 startingPage "5245" @default.
- W4307291228 abstract "Adrenocortical cancer (ACC) typically presents in advanced stages of disease and has a dismal prognosis. One of the foremost reasons for this is the lack of available systemic therapies, with mitotane remaining the backbone of treatment since its discovery in the 1960s, despite underwhelming efficacy. Surgery remains the only potentially curative option, but about half of patients will recur post-operatively, often with metastatic disease. Other local treatment options have been attempted but are only used practically on a case-by-case basis. Over the past few decades there have been significant advances in understanding the molecular background of ACC, but this has not yet translated to better treatment options. Attempts at novel treatment strategies have not provided significant clinical benefit. This paper reviews our current treatment options and molecular understanding of ACC and the reasons why a successful treatment has remained elusive. Additionally, we discuss the knowledge gaps that need to be overcome to bring us closer to successful treatment and ways to bridge them." @default.
- W4307291228 created "2022-10-31" @default.
- W4307291228 creator A5006574108 @default.
- W4307291228 creator A5042814664 @default.
- W4307291228 date "2022-10-26" @default.
- W4307291228 modified "2023-10-14" @default.
- W4307291228 title "Bridging the Scientific Gaps to Identify Effective Treatments in Adrenocortical Cancer" @default.
- W4307291228 cites W1481956726 @default.
- W4307291228 cites W1579447084 @default.
- W4307291228 cites W1742481672 @default.
- W4307291228 cites W1789498548 @default.
- W4307291228 cites W1967352082 @default.
- W4307291228 cites W1982925579 @default.
- W4307291228 cites W1984545852 @default.
- W4307291228 cites W2005466301 @default.
- W4307291228 cites W2019607817 @default.
- W4307291228 cites W2025636912 @default.
- W4307291228 cites W2034712686 @default.
- W4307291228 cites W2035711343 @default.
- W4307291228 cites W2042271589 @default.
- W4307291228 cites W2055827085 @default.
- W4307291228 cites W2058584815 @default.
- W4307291228 cites W2059779476 @default.
- W4307291228 cites W2060610536 @default.
- W4307291228 cites W2074531404 @default.
- W4307291228 cites W2079585988 @default.
- W4307291228 cites W2080838501 @default.
- W4307291228 cites W2082671589 @default.
- W4307291228 cites W2085986924 @default.
- W4307291228 cites W2090978506 @default.
- W4307291228 cites W2093790639 @default.
- W4307291228 cites W2097546758 @default.
- W4307291228 cites W2098622295 @default.
- W4307291228 cites W2099784905 @default.
- W4307291228 cites W2100692201 @default.
- W4307291228 cites W2103205860 @default.
- W4307291228 cites W2107287100 @default.
- W4307291228 cites W2112398213 @default.
- W4307291228 cites W2114566804 @default.
- W4307291228 cites W2116352768 @default.
- W4307291228 cites W2118779298 @default.
- W4307291228 cites W2120218419 @default.
- W4307291228 cites W2130311916 @default.
- W4307291228 cites W2145168501 @default.
- W4307291228 cites W2148365177 @default.
- W4307291228 cites W2191887105 @default.
- W4307291228 cites W2219799372 @default.
- W4307291228 cites W2244278683 @default.
- W4307291228 cites W2263228961 @default.
- W4307291228 cites W2346239022 @default.
- W4307291228 cites W2411724679 @default.
- W4307291228 cites W2461292780 @default.
- W4307291228 cites W2513912419 @default.
- W4307291228 cites W2522598788 @default.
- W4307291228 cites W2531585289 @default.
- W4307291228 cites W2586351160 @default.
- W4307291228 cites W2588463312 @default.
- W4307291228 cites W2594796471 @default.
- W4307291228 cites W2604652960 @default.
- W4307291228 cites W2606495925 @default.
- W4307291228 cites W2609760000 @default.
- W4307291228 cites W2725962181 @default.
- W4307291228 cites W2755330587 @default.
- W4307291228 cites W2755902041 @default.
- W4307291228 cites W2779730509 @default.
- W4307291228 cites W2785265730 @default.
- W4307291228 cites W2788735115 @default.
- W4307291228 cites W2793971568 @default.
- W4307291228 cites W2796207838 @default.
- W4307291228 cites W2803160457 @default.
- W4307291228 cites W2810074202 @default.
- W4307291228 cites W2883682970 @default.
- W4307291228 cites W2886911238 @default.
- W4307291228 cites W2889277392 @default.
- W4307291228 cites W2895620128 @default.
- W4307291228 cites W2898290821 @default.
- W4307291228 cites W2899911867 @default.
- W4307291228 cites W2910724606 @default.
- W4307291228 cites W2911823224 @default.
- W4307291228 cites W2931170698 @default.
- W4307291228 cites W2937296959 @default.
- W4307291228 cites W2938209980 @default.
- W4307291228 cites W2953395929 @default.
- W4307291228 cites W2972679462 @default.
- W4307291228 cites W2974072238 @default.
- W4307291228 cites W2981696991 @default.
- W4307291228 cites W2989332033 @default.
- W4307291228 cites W2999130177 @default.
- W4307291228 cites W3011018027 @default.
- W4307291228 cites W3016779817 @default.
- W4307291228 cites W3031009131 @default.
- W4307291228 cites W3031343722 @default.
- W4307291228 cites W3035917756 @default.
- W4307291228 cites W3036048749 @default.
- W4307291228 cites W3038951562 @default.
- W4307291228 cites W3039155297 @default.
- W4307291228 cites W3096917347 @default.
- W4307291228 cites W3098769160 @default.