Matches in SemOpenAlex for { <https://semopenalex.org/work/W4307299878> ?p ?o ?g. }
Showing items 1 to 100 of
100
with 100 items per page.
- W4307299878 abstract "Abstract Glioblastoma is among the most lethal cancers, with no known cure. A multitude of therapeutics are being developed or in clinical trials, but currently there are no ways to predict which patient may benefit the most from which drug. Assays that allow prediction of the tumor’s response to anti-cancer drugs may improve clinical decision-making. Here, we present a high-density 3D primary cell culture model for short-term testing from resected glioblastoma tissue that is set up on the day of surgery, established within 7 days and viable for at least 3 weeks. High-density 3D cultures contain tumor and host cells, including microglia, and retain key histopathological characteristics of their parent tumors, including proliferative activity, expression of the marker GFAP, and presence of giant cells. This provides a proof-of-concept that 3D primary cultures may be useful to model tumor heterogeneity. Importantly, we show that high-density 3D cultures can be used to test chemotherapy response within a 2– 3-week timeframe and are predictive of patient response to Temozolomide therapy. Thus, primary high-density 3D cultures could be a useful tool for brain cancer research and prediction of therapeutic resistance." @default.
- W4307299878 created "2022-10-31" @default.
- W4307299878 creator A5003141905 @default.
- W4307299878 creator A5012530388 @default.
- W4307299878 creator A5015736861 @default.
- W4307299878 creator A5042446763 @default.
- W4307299878 creator A5051682378 @default.
- W4307299878 creator A5079006091 @default.
- W4307299878 creator A5081447415 @default.
- W4307299878 creator A5089088124 @default.
- W4307299878 date "2022-10-23" @default.
- W4307299878 modified "2023-09-26" @default.
- W4307299878 title "A high-density 3-dimensional culture model of human glioblastoma for rapid screening of therapeutic resistance" @default.
- W4307299878 cites W1994578631 @default.
- W4307299878 cites W1997502785 @default.
- W4307299878 cites W2021577923 @default.
- W4307299878 cites W2030017878 @default.
- W4307299878 cites W2035021866 @default.
- W4307299878 cites W2060551076 @default.
- W4307299878 cites W2109816625 @default.
- W4307299878 cites W2123434257 @default.
- W4307299878 cites W2132866748 @default.
- W4307299878 cites W2151794458 @default.
- W4307299878 cites W2161289668 @default.
- W4307299878 cites W2205491921 @default.
- W4307299878 cites W2263206910 @default.
- W4307299878 cites W2936375023 @default.
- W4307299878 cites W2942860247 @default.
- W4307299878 cites W2961217357 @default.
- W4307299878 cites W2971359145 @default.
- W4307299878 cites W2997979341 @default.
- W4307299878 cites W3159148741 @default.
- W4307299878 cites W3174246647 @default.
- W4307299878 cites W4220938340 @default.
- W4307299878 cites W4250899941 @default.
- W4307299878 cites W785374478 @default.
- W4307299878 doi "https://doi.org/10.1101/2022.10.22.22281352" @default.
- W4307299878 hasPublicationYear "2022" @default.
- W4307299878 type Work @default.
- W4307299878 citedByCount "0" @default.
- W4307299878 crossrefType "posted-content" @default.
- W4307299878 hasAuthorship W4307299878A5003141905 @default.
- W4307299878 hasAuthorship W4307299878A5012530388 @default.
- W4307299878 hasAuthorship W4307299878A5015736861 @default.
- W4307299878 hasAuthorship W4307299878A5042446763 @default.
- W4307299878 hasAuthorship W4307299878A5051682378 @default.
- W4307299878 hasAuthorship W4307299878A5079006091 @default.
- W4307299878 hasAuthorship W4307299878A5081447415 @default.
- W4307299878 hasAuthorship W4307299878A5089088124 @default.
- W4307299878 hasBestOaLocation W43072998781 @default.
- W4307299878 hasConcept C114851261 @default.
- W4307299878 hasConcept C121608353 @default.
- W4307299878 hasConcept C126322002 @default.
- W4307299878 hasConcept C142724271 @default.
- W4307299878 hasConcept C143998085 @default.
- W4307299878 hasConcept C2776194525 @default.
- W4307299878 hasConcept C2776914184 @default.
- W4307299878 hasConcept C2777389519 @default.
- W4307299878 hasConcept C2778681053 @default.
- W4307299878 hasConcept C2779130545 @default.
- W4307299878 hasConcept C2779830541 @default.
- W4307299878 hasConcept C2994463257 @default.
- W4307299878 hasConcept C502942594 @default.
- W4307299878 hasConcept C535046627 @default.
- W4307299878 hasConcept C71924100 @default.
- W4307299878 hasConcept C86803240 @default.
- W4307299878 hasConcept C89423630 @default.
- W4307299878 hasConceptScore W4307299878C114851261 @default.
- W4307299878 hasConceptScore W4307299878C121608353 @default.
- W4307299878 hasConceptScore W4307299878C126322002 @default.
- W4307299878 hasConceptScore W4307299878C142724271 @default.
- W4307299878 hasConceptScore W4307299878C143998085 @default.
- W4307299878 hasConceptScore W4307299878C2776194525 @default.
- W4307299878 hasConceptScore W4307299878C2776914184 @default.
- W4307299878 hasConceptScore W4307299878C2777389519 @default.
- W4307299878 hasConceptScore W4307299878C2778681053 @default.
- W4307299878 hasConceptScore W4307299878C2779130545 @default.
- W4307299878 hasConceptScore W4307299878C2779830541 @default.
- W4307299878 hasConceptScore W4307299878C2994463257 @default.
- W4307299878 hasConceptScore W4307299878C502942594 @default.
- W4307299878 hasConceptScore W4307299878C535046627 @default.
- W4307299878 hasConceptScore W4307299878C71924100 @default.
- W4307299878 hasConceptScore W4307299878C86803240 @default.
- W4307299878 hasConceptScore W4307299878C89423630 @default.
- W4307299878 hasLocation W43072998781 @default.
- W4307299878 hasOpenAccess W4307299878 @default.
- W4307299878 hasPrimaryLocation W43072998781 @default.
- W4307299878 hasRelatedWork W2607536352 @default.
- W4307299878 hasRelatedWork W2623656921 @default.
- W4307299878 hasRelatedWork W2965805323 @default.
- W4307299878 hasRelatedWork W3131446498 @default.
- W4307299878 hasRelatedWork W3166162784 @default.
- W4307299878 hasRelatedWork W3169198564 @default.
- W4307299878 hasRelatedWork W3193555135 @default.
- W4307299878 hasRelatedWork W4282971088 @default.
- W4307299878 hasRelatedWork W4295758394 @default.
- W4307299878 hasRelatedWork W4307299878 @default.
- W4307299878 isParatext "false" @default.
- W4307299878 isRetracted "false" @default.
- W4307299878 workType "article" @default.