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- W4307304208 abstract "The intestine is not a homogeneous organ, but rather organized spaces with specific niches and microenvironments filled with different cell types that are involved in physiological and inflammatory processes. The intestinal mucosa shows a high degree of architectural complexity and intratissue specialization that occurs according to luminal composition. These intratissue specialized environments are critical for the developmental and functional adaptation of immune cells in the gut and in the gut-draining lymph nodes. In this review we discuss the compartmentalization of gut immune responses and how the lymph nodes that drain different regions of the intestine are immunologically, anatomically, and physiologically distinct. We also propose that studies on gut immunity should consider the distinctive features of intestinal segments and the differences in their draining lymph nodes to fully understand the complexity of the gut immunological scenario." @default.
- W4307304208 created "2022-10-31" @default.
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- W4307304208 date "2022-12-01" @default.
- W4307304208 modified "2023-09-30" @default.
- W4307304208 title "Compartmentalization of gut immune responses: Mucosal niches and lymph node peculiarities" @default.
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- W4307304208 doi "https://doi.org/10.1016/j.imlet.2022.10.005" @default.
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